ChemicalBook > CAS DataBase List > 5-bromo-2-(trifluoromethoxyl)benzonitrile

5-bromo-2-(trifluoromethoxyl)benzonitrile

Application

Product Name: 5-bromo-2-(trifluoromethoxyl)benzonitrile
CAS No.: 1210906-15-2
Chemical Name: 5-bromo-2-(trifluoromethoxyl)benzonitrile
Synonyms: 5-Bromo-2-(trifluoromethoxy)benzonitrile;2-(Trifluoromethoxy)-5-bromobenzonitrile;Benzonitrile, 5-bromo-2-(trifluoromethoxy)-;2-trifluoromethoxy-5-bromophenyl-carbonitrile
CBNumber: CB82473716
Molecular Formula: C8H3BrF3NO
Formula Weight: 266.01
MOL File: 1210906-15-2.mol

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5-bromo-2-(trifluoromethoxyl)benzonitrile Property

Boiling point:: 244℃
Density: 1.75
Flash point:: 101℃
storage temp.: Sealed in dry,Room Temperature
form: liquid
color: Clear, almost colourless

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Safety

HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: B695213
Product name: 5-Bromo-2-(trifluoromethoxy)benzonitrile
Packaging: 500mg
Price: $90
Updated: 2021/12/16

Apolloscientific

Product number: PC6919
Product name: 5-Bromo-2-(trifluoromethoxy)benzonitrile
Purity: 99+%
Packaging: 1g
Price: $30
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4637-B-02
Product name: 5-Bromo-2-(trifluoromethoxy)benzonitrile
Purity: 97%
Packaging: 1g
Price: $36
Updated: 2021/12/16

Matrix Scientific

Product number: 119719
Product name: 5-Bromo-2-(trifluoromethoxy)benzonitrile
Purity: 95+%
Packaging: 1g
Price: $52
Updated: 2021/12/16

AK Scientific

Product number: Z3981
Product name: 5-Bromo-2-(trifluoromethoxy)benzonitrile
Packaging: 1g
Price: $95
Updated: 2021/12/16

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5-bromo-2-(trifluoromethoxyl)benzonitrile Chemical Properties,Usage,Production

Application

2-Trifluoromethoxy-5-bromobenzonitrile can be used as an organic synthesis intermediate and a pharmaceutical intermediate in laboratory research and development processes and in the synthesis of pharmaceutical chemicals.

Chemical Properties

Off-white crystalline

Synthesis

923281-52-1

1210906-15-2

The general procedure for synthesizing 2-trifluoromethoxy-5-bromobenzonitrile from 5-bromo-2-(trifluoromethoxy)benzaldehyde is as follows (reference Example 85): to a solution of 5-bromo-2-(trifluoromethoxy)benzaldehyde (2.00 g, 7.43 mmol) and hydroxylamine hydrochloride (568 mg, 8.18 mmol) in DMF (7.5 mL), was added sequentially triethylamine ( 1.14 mL, 8.18 mmol) and propylphosphonic anhydride (cyclic trimer, ~1.7 M ethyl acetate solution, 4.8 mL, 8.18 mmol). The reaction mixture was stirred at 100°C for 8 hours. Upon completion of the reaction, the reaction solution was poured into saturated aqueous sodium bicarbonate solution and extracted with ethyl acetate. The organic layers were combined, washed with brine and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure, and the resulting residue was purified by silica gel column chromatography [eluent: hexane/ethyl acetate=100/0-98/2] to afford the target product 2-trifluoromethoxy-5-bromobenzonitrile (1.71 g, yield: 86%).1H-NMR (400 MHz, CDCl3) δ: 7.85 (1H, d, J=3Hz), 7.78 (1H. dd, J=9,3Hz), 7.31-7.27 (1H, m).

References

[1] Patent: EP2862861, 2015, A1. Location in patent: Paragraph 0586; 0587; 0588
[2] Patent: JP2015/113323, 2015, A. Location in patent: Paragraph 0541 - 0543

5-bromo-2-(trifluoromethoxyl)benzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-bromo-2-(trifluoromethoxyl)benzonitrile manufacturers

Honest Joy Holdings Limited

Product: 5-Bromo-2-(trifluoromethoxy)benzonitrile 1210906-15-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.7%
Supply Ability: 100 tons
Release date: 2022-01-14

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1210906-15-2