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CP-547632

Product Name
CP-547632
CAS No.
252003-65-9
Chemical Name
CP-547632
Synonyms
CS-1957;CP-547632;CP-547632(CP 547632);CP-547632 (PAN-90806);CP-547632, 10 mM in DMSO;3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carbox;3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxami;3-[(4-Bromo-2,6-difluorobenzyl)oxy]-5-[3-[4-(pyrrolidin-1-yl)butyl]ureido]isothiazole-4-carboxamide;3-(4-Bromo-2,6-difluorobenzyloxy)-5-(3-(4-pyrrolidin-1-ylbutyl)ureido)isothiazole-4-carboxylic acid amide;3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-(4-pyrrolidin-1-ylbutylcarbamoylamino)-1,2-thiazole-4-carboxamide
CBNumber
CB82473822
Molecular Formula
C20H24BrF2N5O3S
Formula Weight
532.4
MOL File
252003-65-9.mol
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CP-547632 Property

Boiling point:
548.6±50.0 °C(Predicted)
Density 
1.532
storage temp. 
2-8°C
solubility 
DMSO: 94 mM
form 
A solid
pka
12.50±0.70(Predicted)
color 
White to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21773
Product name
CP 547,632
Purity
≥98%
Packaging
500μg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
21773
Product name
CP 547,632
Purity
≥98%
Packaging
1mg
Price
$107
Updated
2024/03/01
Cayman Chemical
Product number
21773
Product name
CP 547,632
Purity
≥98%
Packaging
5mg
Price
$437
Updated
2024/03/01
ChemScene
Product number
CS-0003189
Product name
CP-547632
Purity
>99.0%
Packaging
50mg
Price
$580
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB102944
Product name
3-[(4-Bromo-2,6-difluorobenzyl)oxy]-5-[3-[4-(pyrrolidin-1-yl)butyl]ureido]isothiazole-4-carboxamide
Packaging
25mg
Price
$750
Updated
2021/12/16
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CP-547632 Chemical Properties,Usage,Production

Description

CP 547,632 is an orally bioavailable and potent inhibitor of the receptor tyrosine kinases VEGF receptor 2 (VEGFR2) and basic fibroblast growth factor (bFGF) with IC50 values of 11 and 9 nM, respectively, in an enzyme assay. It is selective for VEGFR2 and bFGF over EGFR, PDGF receptor β (PDGFRβ), and related tyrosine kinases. CP 547,632 inhibits VEGFR2 autophosphorylation induced by VEGF in porcine aortic endothelial cells transfected with VEGFR2 (IC50 = 6 nM) and in a xenograft mouse model using NIH3T3/H-Ras cells (EC50 = 590 nM). It decreases angiogenesis induced by VEGF or bFGF and suppresses tumor growth in athymic mice.

Uses

CP-547632 is an orally active, ATP-competitive and potent VEGFR-2 and FGF kinases inhibitor with IC50s of 11 nM and 9 nM, respectively. CP-547632 is selective for VEGFR2 and bFGF over EGFR, PDGFRβ, and related tyrosine kinases (TKs). CP-547632 has antitumor efficacy[1].

in vivo

CP-547632 (p.o.; 6.25-100 mg/kg/day; for 10-24 days) causes a dose-dependent inhibition of growth in Colo-205, DLD-1, and MDA-MB-231 xenografts[1].
CP-547632 (oral; 50 mg/kg; a single oral dose) yieldes plasma concentrations above 500 ng/ml for 12 hours[1].

Animal Model:Athymic female mice (CD-1 nu/nu) bearing tumors (75-150 mm in size)[1]
Dosage:6.25, 12.5, 25, 50, 100 mg/kg
Administration:PO; daily; 10-24 days
Result:Caused a dose-dependent inhibition of growth in Colo-205, DLD-1, and MDA-MB-231 xenografts.
Animal Model:Female athymic mice bearing H-Ras tumor[1]
Dosage:50 mg/kg
Administration:Oral
Result:A single oral dose of 50 mg/kg yielded plasma concentrations above 500 ng/ml for 12 hours.

IC 50

VEGFR-2: 11 nM (IC50); FGFR: 9 nM (IC50)

References

[1] Beebe JS, et al. Pharmacological characterization of CP-547,632, a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for cancer therapy. Cancer Res. 2003 Nov 1;63(21):7301-9. PMID:14612527

CP-547632 Preparation Products And Raw materials

Raw materials

Preparation Products

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CP-547632 Suppliers

China 67 United Kingdom 1 United States 9 Global 77
Hangzhou FuRun Pharmaceutical Technology Co., Ltd
Tel
15658004993
Email
1900830611@qq.com
Country
China
ProdList
978
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
China Kouting Group Limited
Tel
+86 (21) 5811-6473 5811-6475
Fax
+86 (21) 6129-4103
Email
sales@koutingchina.com
Country
China
ProdList
496
Advantage
60
China Nobel Chem Co., Limited
Tel
+86(0)21 60484900
Fax
+86(0)21 60484900
Country
China
ProdList
764
Advantage
50
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4720
Advantage
55
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
Tianjin Anhao Biological Technology Co., Ltd.
Tel
Email
sales@ahpharmatech.com
Country
China
ProdList
5734
Advantage
55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66028182 18626450290
Email
yftan@aikonchem.com
Country
China
ProdList
16684
Advantage
50
Shanghai Tombiopharma Chemical Co. Ltd.
Tel
13391076197
Email
tombiopharma@163.com
Country
China
ProdList
4987
Advantage
55
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View Lastest Price from CP-547632 manufacturers

Career Henan Chemical Co
Product
CP-547632 252003-65-9
Price
US $1.00/g
Min. Order
1g
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-10

252003-65-9, CP-547632Related Search:

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  • CP-547632, 10 mM in DMSO
  • 252003-65-9
  • C20H24BrF2N5O3S