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CP-547632

Product Name
CP-547632
CAS No.
252003-65-9
Chemical Name
CP-547632
Synonyms
CS-1957;CP-547632;CP-547632(CP 547632);CP-547632 (PAN-90806);3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carbox;3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxami;3-[(4-Bromo-2,6-difluorobenzyl)oxy]-5-[3-[4-(pyrrolidin-1-yl)butyl]ureido]isothiazole-4-carboxamide;3-(4-Bromo-2,6-difluorobenzyloxy)-5-(3-(4-pyrrolidin-1-ylbutyl)ureido)isothiazole-4-carboxylic acid amide;3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-(4-pyrrolidin-1-ylbutylcarbamoylamino)-1,2-thiazole-4-carboxamide;3-[(4-broMo-2,6-difluorophenyl)Methoxy]-5-[[[[4-(1-pyrrolidinyl)butyl]aMino]carbonyl]aMino]-4-isothiazolecarboxaMide
CBNumber
CB82473822
Molecular Formula
C20H24BrF2N5O3S
Formula Weight
532.4
MOL File
252003-65-9.mol
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CP-547632 Property

Boiling point:
548.6±50.0 °C(Predicted)
Density 
1.532
storage temp. 
2-8°C
solubility 
DMSO: 94 mM
form 
A solid
pka
12.50±0.70(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21773
Product name
CP 547,632
Purity
≥98%
Packaging
500μg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
21773
Product name
CP 547,632
Purity
≥98%
Packaging
1mg
Price
$107
Updated
2024/03/01
Cayman Chemical
Product number
21773
Product name
CP 547,632
Purity
≥98%
Packaging
5mg
Price
$437
Updated
2024/03/01
ChemScene
Product number
CS-0003189
Product name
CP-547632
Purity
>99.0%
Packaging
50mg
Price
$580
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB102944
Product name
3-[(4-Bromo-2,6-difluorobenzyl)oxy]-5-[3-[4-(pyrrolidin-1-yl)butyl]ureido]isothiazole-4-carboxamide
Packaging
25mg
Price
$750
Updated
2021/12/16
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CP-547632 Chemical Properties,Usage,Production

Description

CP 547,632 is an orally bioavailable and potent inhibitor of the receptor tyrosine kinases VEGF receptor 2 (VEGFR2) and basic fibroblast growth factor (bFGF) with IC50 values of 11 and 9 nM, respectively, in an enzyme assay. It is selective for VEGFR2 and bFGF over EGFR, PDGF receptor β (PDGFRβ), and related tyrosine kinases. CP 547,632 inhibits VEGFR2 autophosphorylation induced by VEGF in porcine aortic endothelial cells transfected with VEGFR2 (IC50 = 6 nM) and in a xenograft mouse model using NIH3T3/H-Ras cells (EC50 = 590 nM). It decreases angiogenesis induced by VEGF or bFGF and suppresses tumor growth in athymic mice.

CP-547632 Preparation Products And Raw materials

Raw materials

Preparation Products

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CP-547632 Suppliers

China 53 United Kingdom 1 United States 8 Global 62
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View Lastest Price from CP-547632 manufacturers

Career Henan Chemical Co
Product
CP-547632 252003-65-9
Price
US $1.00/g
Min. Order
1g
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-10

252003-65-9, CP-547632Related Search:

1,1-DIBROMOTETRAFLUOROETHANE α-Bromo-2,3,4,5,6-pentafluorotoluene

  • CP-547632
  • 3-(4-Bromo-2,6-difluorobenzyloxy)-5-(3-(4-pyrrolidin-1-ylbutyl)ureido)isothiazole-4-carboxylic acid amide
  • 4-Isothiazolecarboxamide, 3-((4-bromo-2,6-difluorophenyl)methoxy)-5-((((4-(1-pyrrolidinyl)butyl)amino)carbonyl)amino)-
  • CP-547632(CP 547632)
  • 3-[(4-broMo-2,6-difluorophenyl)Methoxy]-5-[[[[4-(1-pyrrolidinyl)butyl]aMino]carbonyl]aMino]-4-isothiazolecarboxaMide
  • 3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxami
  • 3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carbox
  • 3-[(4-Bromo-2,6-difluorobenzyl)oxy]-5-[3-[4-(pyrrolidin-1-yl)butyl]ureido]isothiazole-4-carboxamide
  • CS-1957
  • CP-547632 (PAN-90806)
  • 3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-(4-pyrrolidin-1-ylbutylcarbamoylamino)-1,2-thiazole-4-carboxamide
  • 252003-65-9
  • C20H24BrF2N5O3S