ChemicalBook > CAS DataBase List > (1R,2R)-1,2-Cyclohexanedimethanol

(1R,2R)-1,2-Cyclohexanedimethanol

Product Name
(1R,2R)-1,2-Cyclohexanedimethanol
CAS No.
65376-05-8
Chemical Name
(1R,2R)-1,2-Cyclohexanedimethanol
Synonyms
[(1R,2R)-2-(hydroxymethyl)cyclohexyl]methanol;Lurasidone KSM / (1R,2R)-1,2-;(1R,2R)-cyclohexane-1,2-diyldimethanol;(1R,2R)-1,2-Bis(hydroxymethyl)cyclohexane;Lurasidone INT 3;(1R,2R)-1,2-CYCLOHEXANEDI;Lurasidone HCL Intermediates;(R,R)-Cyclohexane-1,2-dimethanol;(1R,2R)-1,2-CYCLOHEXANEDIMETHANO;(1R,2R)-1,2-CYCLOHEXANEDIMETHANOL
CBNumber
CB82474687
Molecular Formula
C8H16O2
Formula Weight
144.21
MOL File
65376-05-8.mol
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(1R,2R)-1,2-Cyclohexanedimethanol Property

Melting point:
63.0 to 67.0 °C
Boiling point:
270℃
Density 
1.004
Flash point:
129℃
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
14.75±0.10(Predicted)
color 
White to Off-White
InChI
InChI=1S/C8H16O2/c9-5-7-3-1-2-4-8(7)6-10/h7-10H,1-6H2/t7-,8-/m0/s1
InChIKey
XDODWINGEHBYRT-YUMQZZPRSA-N
SMILES
[C@@H]1(CO)CCCC[C@H]1CO
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Safety

HS Code 
2906.19.5000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
C2978
Product name
(1R,2R)-1,2-Cyclohexanedimethanol
Purity
>98.0%(GC)
Packaging
1g
Price
$127
Updated
2025/07/31
TCI Chemical
Product number
C2978
Product name
(1R,2R)-1,2-Cyclohexanedimethanol
Purity
>98.0%(GC)
Packaging
5g
Price
$382
Updated
2025/07/31
TRC
Product number
C987945
Product name
(1R,2R)-1,2-Cyclohexanedimethanol
Packaging
250mg
Price
$1355
Updated
2021/12/16
Activate Scientific
Product number
AS3804-1R2R
Product name
(1R,2R)-1,2-Cyclohexanedimethanol
Purity
97+%
Packaging
5G
Price
$47
Updated
2021/12/16
AK Scientific
Product number
X6176
Product name
(1R,2R)-1,2-Cyclohexanedimethanol
Packaging
5g
Price
$93
Updated
2021/12/16
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(1R,2R)-1,2-Cyclohexanedimethanol Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

(1R,2R)-1,2-Cyclohexanedimethanol (cas# 65376-05-8) is a compound useful in organic synthesis.

Synthesis

46022-05-3

65376-05-8

General procedure for the synthesis of (1R,2R)-1,2-cyclohexanedicarboxylic acid as a raw material for the synthesis of (1R,2R)-1,2-cyclohexanedimethanol: A mixture of (1R,2R)-1,2-cyclohexanedicarboxylic acid (248 g, 1.41 mol), sodium borohydride (159.8 g, 4.2 mol), and iodine (156 g, 0.7 mol) was added to tetrahydrofuran ( THF, 1000 mL), stirred, and reacted at reflux for 5 hours. After completion of the reaction, the reaction mixture was cooled to 0 °C and methanol (500 mL) was added slowly and dropwise. The organic layer was separated, dried with anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure and dried to give the white solid product (1R,2R)-1,2-cyclohexanedimethanol (178 g, 1.709 mol, 88.4% yield) with a melting point of 57-59 °C.

References

[1] Patent: CN105732644, 2016, A. Location in patent: Paragraph 0006; 0007
[2] Synthetic Communications, 2015, vol. 45, # 23, p. 2676 - 2682
[3] Tetrahedron, 1965, vol. 21, p. 1701 - 1709
[4] Patent: WO2013/121440, 2013, A1. Location in patent: Page/Page column 27
[5] Patent: WO2016/59649, 2016, A1. Location in patent: Paragraph 20

(1R,2R)-1,2-Cyclohexanedimethanol Preparation Products And Raw materials

Raw materials

Preparation Products

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(1R,2R)-1,2-Cyclohexanedimethanol Suppliers

Americas 1 Canada 2 China 314 Europe 1 Germany 1 India 35 Japan 1 United Kingdom 6 United States 16 Global 377
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
Vihita Chem
Tel
--
Fax
--
Email
info@vihita.com
Country
Canada
ProdList
73
Advantage
38
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View Lastest Price from (1R,2R)-1,2-Cyclohexanedimethanol manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
(1R,2R)-1,2-CYCLOHEXANEDIMETHANOL 65376-05-8
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-06
Jinan Million Pharmaceutical Co., Ltd
Product
(1R,2R)-1,2-CYCLOHEXANEDIMETHANOL 65376-05-8
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1200KG/M
Release date
2023-08-15
Henan Aochuang Chemical Co.,Ltd.
Product
(1R,2R)-1,2-CYCLOHEXANEDIMETHANOL 65376-05-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30

65376-05-8, (1R,2R)-1,2-Cyclohexanedimethanol Related Search:

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  • 1,2-Cyclohexanedimethanol, (1R-trans)-
  • (1R,2R)-1,2-Cyclohexanedimethanol(For export only)
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  • 65376-05-8
  • Miscellaneous Reagents