ChemicalBook > CAS DataBase List > 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one

6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one

Product Name
6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one
CAS No.
35570-68-4
Chemical Name
6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one
Synonyms
6-Chlorooxazolo[4,5-b]pyridin-2(3H);6-Chloro-3H-oxazolo[4,5-b]pyridin-2-one;6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one;6-chlorooxazole[4,5-b]pyridine-2(3H)-one;Oxazolo[4,5-b]pyridin-2(3H)-one, 6-chloro-;6-chloro-3H-[1,3]oxazolo[4,5-b]pyridin-2-one;6-chloro[1,3]oxazolo[4,5-b]pyridin-2(3H)-one;6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one （Crizotinib intermediate）
CBNumber
CB82484862
Molecular Formula
C6H3ClN2O2
Formula Weight
170.55
MOL File
35570-68-4.mol
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6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one Property

Melting point:
183-186℃
Density 
1.80
storage temp. 
Sealed in dry,Room Temperature
Appearance
White to off-white Solid
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C374938
Product name
6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one
Packaging
500mg
Price
$310
Updated
2021/12/16
Apolloscientific
Product number
OR939132
Product name
6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one
Purity
95%
Packaging
1g
Price
$435
Updated
2021/12/16
Apolloscientific
Product number
OR939132
Product name
6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one
Purity
95%
Packaging
250mg
Price
$185
Updated
2021/12/16
AK Scientific
Product number
4439AB
Product name
6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one
Packaging
5g
Price
$232
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0368023
Product name
6-CHLOROOXAZOLO-[4,5-B]PYRIDIN-2(3H)-ONE
Purity
95.00%
Packaging
5MG
Price
$504.11
Updated
2021/12/16
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6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one Chemical Properties,Usage,Production

Synthesis

60832-72-6

35570-68-4

The general procedure for the synthesis of 6-chloro-oxazolo[4,5-b]pyridin-2(3H)-one using 2,3-dihydropyrido[2,3-d][1,3]oxazol-2-one as starting material was as follows: first, DMF (9 L) was added to a 100 L autoclave, a mechanical stirrer was started, and 2,3-dihydropyrido[2,3-d][1,3]oxazol-2-one ( 10 kg) and stirred until completely dissolved. Subsequently, N-chlorosuccinimide (12.16 kg) was dissolved in DMF (30 L) and slowly added dropwise to the reactor, during which the temperature of the reaction was controlled not to exceed 40 °C (cooled by a circulating condensate pump if necessary). After dropwise addition, the reaction mixture was stirred at room temperature overnight. The reaction progress was monitored by TLC and GC. Upon completion of the reaction, water (39 L) was slowly added under cooling conditions and stirring was continued for 60 minutes before filtration. The filter cake was washed twice with water and subsequently dried under vacuum to give a crude product of 11.8 kg.Finally, the crude product was recrystallized by dichloromethane and ethyl acetate to give the pure product 6-chloroxazolo[4,5-b]pyridin-2(3H)-one (11.1 kg) in 89% yield.

References

[1] Patent: CN103709175, 2016, B. Location in patent: Paragraph 0024-0025
[2] Patent: CN103755627, 2016, B. Location in patent: Paragraph 0022; 0023
[3] Patent: WO2018/37223, 2018, A1. Location in patent: Page/Page column 222
[4] Helvetica Chimica Acta, 1976, vol. 59, p. 1593 - 1612

6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one Suppliers

China 87 India 1 United States 5 Global 93
Alchem Pharmtech,Inc.
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Matrix Scientific
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View Lastest Price from 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one manufacturers

Shaanxi Haibo Biotechnology Co., Ltd
Product
6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one 35570-68-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-08-31
Career Henan Chemical Co
Product
6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one 35570-68-4
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-07-04

35570-68-4, 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-oneRelated Search:

6-chloropyrido[3,2-b]pyrazine 6-chlorophthalazine 2-Pyrazinecarboxylic acid, 6-chloro-, ethyl ester 6-Chloro-pyridazine-3-carboxylic acid ethyl ester 6-Chloropyridazine-3-carboxamide 6-chloropyrido[2,3-d]pyrimidin-2-amine

  • Oxazolo[4,5-b]pyridin-2(3H)-one, 6-chloro-
  • 6-chloro-3H-[1,3]oxazolo[4,5-b]pyridin-2-one
  • 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one
  • 6-Chloro-3H-oxazolo[4,5-b]pyridin-2-one
  • 6-Chlorooxazolo[4,5-b]pyridin-2(3H)
  • 6-chlorooxazole[4,5-b]pyridine-2(3H)-one
  • 6-chloro[1,3]oxazolo[4,5-b]pyridin-2(3H)-one
  • 6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one （Crizotinib intermediate）
  • 35570-68-4