3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole

Product Name: 3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole
CAS No.: 395104-30-0
Chemical Name: 3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole
Synonyms: CC-401;CS-400;JNK-401);CC-401 (HCl);CC-401, >=98%;CC-401 (CC401;1-[5-(1H-1,2,4-Triazol-5-yl)-1H-indazol-3-yl]-3-(2-piperidinoethoxy)benzene;3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole;3-(3-(2-(piperidin-1-yl)ethoxy)phenyl)-5-(1H-1,2,4-triazol-3-yl)-1H-indazole;3-(3-(2-(Piperidin-1-yl)ethoxy)phenyl)-5-(1H-1,2,4-triazol-5-yl)-1H-indazole
CBNumber: CB82484877
Molecular Formula: C22H24N6O
Formula Weight: 388.47
MOL File: 395104-30-0.mol

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3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole Property

Boiling point:: 681.5±65.0 °C(Predicted)
Density: 1.275
storage temp.: Store at -20°C
solubility: ≥19.4 mg/mL in DMSO; ≥2.32 mg/mL in EtOH with ultrasonic; ≥8.7 mg/mL in H2O
form: solid
pka: 9.44±0.20(Predicted)

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18867
Product name: CC-401
Purity: ≥98%
Packaging: 5mg
Price: $467
Updated: 2024/03/01

Cayman Chemical

Product number: 18867
Product name: CC-401
Purity: ≥98%
Packaging: 10mg
Price: $826
Updated: 2024/03/01

Cayman Chemical

Product number: 18867
Product name: CC-401
Purity: ≥98%
Packaging: 1mg
Price: $106
Updated: 2024/03/01

TRC

Product number: C227860
Product name: CC-401
Packaging: 5mg
Price: $370
Updated: 2021/12/16

ApexBio Technology

Product number: B1260
Product name: CC-401
Packaging: 10mg
Price: $251
Updated: 2021/12/16

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3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole Chemical Properties,Usage,Production

Description

c-Jun N-terminal kinases (JNKs) are MAP kinase family members that become highly activated after cells are exposed to stress conditions and are poorly activated by exposure to growth factors or mitogens. CC-401 is a potent inhibitor of all three JNK isoforms (K_i values range from 25 to 50 nM). It has at least 40-fold selectivity for JNK compared with other related kinases. CC-401 is bioavailable when delivered by gavage, blocking JNK signaling and renal fibrosis in a rat obstructed kidney model. It also has been shown to decrease hepatic necrosis and apoptosis after orthotopic liver transplantation and prevent acute renal failure following ischemia/reperfusion associated with renal transplantation in rats.

Uses

CC-401 inhibits c-JUN N-terminal kinases (JNKs) by binding to its ATP-binding site. JNKs belong to the MAP kinase family and respond to stress signals such as heat, cytokines, and osmotic shock.

Definition

ChEBI: 3-[3-[2-(1-piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole is a member of pyrazoles and a ring assembly.

in vivo

The staining of p-JNK is moderately induced in bevazicumab and Oxaliplatin treatments as compared to control, and in the CC-401-treated samples p-cJun content is significantly lower, consistent with effective JNK inhibition. DNA damage is modestly elevated in combined treatments with CC-401^[2]. CC-401 treatment from days 7 to 24 slows the progression of proteinuria, which is significantly reduced compared to the no-treatment and vehicle groups at days 14 and 21. However, there is still an increase in the degree of proteinuria at day 21 in CC-401-treated rats compared to proteinuria at day 5. The vehicle and no-treatment groups developed renal impairment at day 24 as shown by an increase in serum creatinine. This is prevented by CC-401 treatment^[3].

IC 50

JNK: 25-50 nM (Ki)

References

[1] ma f y, flanc r s, tesch g h, et al. a pathogenic role for c-jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis. journal of the american society of nephrology, 2007, 18(2): 472-484.
[2] flanc r s, ma f y, tesch g h, et al. a pathogenic role for jnk signaling in experimental anti-gbm glomerulonephritis. kidney international, 2007, 72(6): 698-708.
[3] bogoyevitch m a, arthur p g. inhibitors of c-jun n-terminal kinases—junk no more biochimica et biophysica acta (bba)-proteins and proteomics, 2008, 1784(1): 76-93.

3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole manufacturers

Career Henan Chemical Co

Product: 3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole 395104-30-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2019-12-31

395104-30-0, 3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazoleRelated Search:

Acetyl chloride

3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole

CC-401

CC-401 (HCl)

1-[5-(1H-1,2,4-Triazol-5-yl)-1H-indazol-3-yl]-3-(2-piperidinoethoxy)benzene

CC-401 (CC401

JNK-401)

CS-400

3-(3-(2-(piperidin-1-yl)ethoxy)phenyl)-5-(1H-1,2,4-triazol-3-yl)-1H-indazole

CC4013-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole

CC-401, >=98%

3-(3-(2-(Piperidin-1-yl)ethoxy)phenyl)-5-(1H-1,2,4-triazol-5-yl)-1H-indazole

1H-Indazole, 3-[3-[2-(1-piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-

395104-30-0