5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine

Product Name: 5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine
CAS No.: 1111638-02-8
Chemical Name: 5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine
Synonyms: 2-Methyl-5-bromo-7-azaindole;5-Bromo-2-methyl-7-Azaind...;5-Bromo-2-methyl-7-Azaindole;5-Bromo-2-iodo-1H-pyrrolo[2,3-b]pyridine;5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 5-broMo-2-Methyl-
CBNumber: CB82489968
Molecular Formula: C8H7BrN2
Formula Weight: 211.06
MOL File: 1111638-02-8.mol

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5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine Property

Density: 1.654
storage temp.: Sealed in dry,Room Temperature
pka: 13.49±0.40(Predicted)
form: powder
color: Yellow

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Safety

Hazard Codes: Xn
Risk Statements: 22-41
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE001093
Product name: 5-Bromo-2-iodo-1H-pyrrolo[2,3-b]pyridine
Purity: Aldrich<SUP>CPR</SUP>
Packaging: 1 g
Price: $1030
Updated: 2025/07/31

Sigma-Aldrich

Product number: ADE001092
Product name: 5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine
Purity: Aldrich
Packaging: 1g
Price: $1030
Updated: 2025/07/31

TRC

Product number: B697663
Product name: 5-Bromo-2-methyl-1h-pyrrolo[2,3-b]pyridine
Packaging: 50mg
Price: $65
Updated: 2021/12/16

Matrix Scientific

Product number: 059416
Product name: 5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine
Packaging: 250mg
Price: $115
Updated: 2021/12/16

Matrix Scientific

Product number: 059416
Product name: 5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine
Packaging: 500mg
Price: $205
Updated: 2021/12/16

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5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine Chemical Properties,Usage,Production

Synthesis

1111638-01-7

1111638-02-8

Preparation of Method A Steps for the synthesis of intermediate 4: 5-bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine: Ingredient 3 (88 mg, 0.251 mmol) was dissolved in methanol (4 mL), 2 N sodium hydroxide solution (1 mL) was added, and the reaction mixture was heated and refluxed for 2 hours. After completion of the reaction, ethyl acetate was added for extraction and the organic phase was washed sequentially with 1 N sodium hydroxide solution and water. Purification by silica gel column chromatography (slow gradient elution, volume fraction of methanol in dichloromethane increased from 0% to 2%) afforded the target product 4 (40 mg, 0.19 mmol, 76% yield). Product characterization data were as follows: 1H NMR (CDCl3, 300 MHz): δ 10.26 (br s, 1H), 8.22 (d, J = 2.1 Hz, 1H), 8.92 (d, J = 2.1 Hz, 1H), 6.13 (s, 1H), 2.52 (s, 3H). MS (m/z): 210 (M + H).

References

[1] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 5, p. 582 - 586
[2] Patent: WO2011/149950, 2011, A2. Location in patent: Page/Page column 151-152
[3] Patent: WO2014/85795, 2014, A1. Location in patent: Paragraph 0394
[4] Bioorganic Chemistry, 2016, vol. 65, p. 146 - 158
[5] Patent: WO2009/16460, 2009, A2. Location in patent: Page/Page column 74

5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine Suppliers

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View Lastest Price from 5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine manufacturers

Career Henan Chemical Co

Product: 5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine 1111638-02-8
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-08

1111638-02-8, 5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridineRelated Search:

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