2-Bromo-4,5-difluorobenzaldehyde
- Product Name
- 2-Bromo-4,5-difluorobenzaldehyde
- CAS No.
- 476620-54-9
- Chemical Name
- 2-Bromo-4,5-difluorobenzaldehyde
- Synonyms
- 5-difluorobenzaldehyde;2-Bromo-4,5-difluorobenzaldehyde;Benzaldehyde, 2-bromo-4,5-difluoro-;2-Bromo-4,5-difluorobenzaldehyde,98%;2-Bromo-4,5-difluorobenzaldehyde ISO 9001：2015 REACH
- CBNumber
- CB82490913
- Molecular Formula
- C7H3BrF2O
- Formula Weight
- 221
- MOL File
- 476620-54-9.mol
2-Bromo-4,5-difluorobenzaldehyde Property
- Boiling point:
- 232.0±35.0 °C(Predicted)
- Density
- 1.758±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- form
- Powder
- color
- Off-white
- Water Solubility
- Slightly soluble in water.
Safety
- HS Code
- 2913000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B997240
- Product name
- 2-Bromo-4,5-difluorobenzaldehyde
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 2615-B-X8
- Product name
- 2-Bromo-4,5-difluorobenzaldehyde
- Packaging
- 100mg
- Price
- $67
- Updated
- 2021/12/16
- Product number
- 100605
- Product name
- 2-Bromo-4,5-difluorobenzaldehyde
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $19
- Updated
- 2021/12/16
- Product number
- V6104
- Product name
- 2-Bromo-4,5-difluorobenzaldehyde
- Packaging
- 250mg
- Price
- $23
- Updated
- 2021/12/16
- Product number
- 100605
- Product name
- 2-Bromo-4,5-difluorobenzaldehyde
- Purity
- 95+%
- Packaging
- 500mg
- Price
- $29
- Updated
- 2021/12/16
2-Bromo-4,5-difluorobenzaldehyde Chemical Properties,Usage,Production
Uses
It is an important intermediate for pharmaceutical and organic synthesis.
Synthesis
476620-55-0
476620-54-9
General procedure for the synthesis of 2-bromo-4,5-difluorobenzaldehyde from (2-bromo-4,5-difluorophenyl)methanol: (2-bromo-4,5-difluorophenyl)methanol (1.23 g, 5.50 mmol), triethylamine (1.39 g, 13.75 mmol) and dimethylsulfoxide (1.72 g, 22.00 mmol) were dissolved in dichloromethane (25 mL) in dichloromethane (25 mL) and cooled to 0°C. Subsequently, sulfur trioxide-pyridine complex (1.32 g, 8.25 mmol) was added in batches. The reaction mixture was stirred at 0 °C for 1 h. Triethylamine (1.39 g, 13.75 mmol), dimethyl sulfoxide (1.72 g, 22.00 mmol) and sulfur trioxide-pyridine complex (1.32 g, 8.25 mmol) were added again. After continued stirring at 0 °C for 30 min, the reaction solution was diluted with dichloromethane (50 mL) and washed sequentially with saturated sodium bicarbonate solution and saturated sodium thiosulfate solution. The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Purification by fast column chromatography (RediSep fast column, 230-400 mesh silica gel, eluent 10-30% ethyl acetate in hexane solution) afforded 2-bromo-4,5-difluorobenzaldehyde (0.47 g, 39% yield).1H NMR (300 MHz, CDCl3) δ 10.23 (s, 1H), 7.77 (m, 1H), 7.52 (m, 1H).
References
[1] Patent: WO2010/55005, 2010, A1. Location in patent: Page/Page column 70-71
[2] Patent: WO2011/20193, 2011, A1. Location in patent: Page/Page column 18-19
[3] Patent: WO2011/57382, 2011, A1. Location in patent: Page/Page column 21
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 5, p. 1953 - 1957
2-Bromo-4,5-difluorobenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Bromo-4,5-difluorobenzaldehyde manufacturers
- Product
- 2-Bromo-4,5-difluorobenzaldehyde 476620-54-9
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-17