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2-Bromo-4,5-difluorobenzaldehyde

Product Name
2-Bromo-4,5-difluorobenzaldehyde
CAS No.
476620-54-9
Chemical Name
2-Bromo-4,5-difluorobenzaldehyde
Synonyms
5-difluorobenzaldehyde;2-Bromo-4,5-difluorobenzaldehyde;Benzaldehyde, 2-bromo-4,5-difluoro-;2-Bromo-4,5-difluorobenzaldehyde,98%;2-Bromo-4,5-difluorobenzaldehyde ISO 9001：2015 REACH
CBNumber
CB82490913
Molecular Formula
C7H3BrF2O
Formula Weight
221
MOL File
476620-54-9.mol
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2-Bromo-4,5-difluorobenzaldehyde Property

Boiling point:
232.0±35.0 °C(Predicted)
Density 
1.758±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
form 
Powder
color 
Off-white
Water Solubility 
Slightly soluble in water.
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Safety

HS Code 
2913000090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
B997240
Product name
2-Bromo-4,5-difluorobenzaldehyde
Packaging
50mg
Price
$60
Updated
2021/12/16
SynQuest Laboratories
Product number
2615-B-X8
Product name
2-Bromo-4,5-difluorobenzaldehyde
Packaging
100mg
Price
$67
Updated
2021/12/16
Matrix Scientific
Product number
100605
Product name
2-Bromo-4,5-difluorobenzaldehyde
Purity
95+%
Packaging
250mg
Price
$19
Updated
2021/12/16
AK Scientific
Product number
V6104
Product name
2-Bromo-4,5-difluorobenzaldehyde
Packaging
250mg
Price
$23
Updated
2021/12/16
Matrix Scientific
Product number
100605
Product name
2-Bromo-4,5-difluorobenzaldehyde
Purity
95+%
Packaging
500mg
Price
$29
Updated
2021/12/16
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2-Bromo-4,5-difluorobenzaldehyde Chemical Properties,Usage,Production

Uses

It is an important intermediate for pharmaceutical and organic synthesis.

Synthesis

476620-55-0

476620-54-9

General procedure for the synthesis of 2-bromo-4,5-difluorobenzaldehyde from (2-bromo-4,5-difluorophenyl)methanol: (2-bromo-4,5-difluorophenyl)methanol (1.23 g, 5.50 mmol), triethylamine (1.39 g, 13.75 mmol) and dimethylsulfoxide (1.72 g, 22.00 mmol) were dissolved in dichloromethane (25 mL) in dichloromethane (25 mL) and cooled to 0°C. Subsequently, sulfur trioxide-pyridine complex (1.32 g, 8.25 mmol) was added in batches. The reaction mixture was stirred at 0 °C for 1 h. Triethylamine (1.39 g, 13.75 mmol), dimethyl sulfoxide (1.72 g, 22.00 mmol) and sulfur trioxide-pyridine complex (1.32 g, 8.25 mmol) were added again. After continued stirring at 0 °C for 30 min, the reaction solution was diluted with dichloromethane (50 mL) and washed sequentially with saturated sodium bicarbonate solution and saturated sodium thiosulfate solution. The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Purification by fast column chromatography (RediSep fast column, 230-400 mesh silica gel, eluent 10-30% ethyl acetate in hexane solution) afforded 2-bromo-4,5-difluorobenzaldehyde (0.47 g, 39% yield).1H NMR (300 MHz, CDCl3) δ 10.23 (s, 1H), 7.77 (m, 1H), 7.52 (m, 1H).

References

[1] Patent: WO2010/55005, 2010, A1. Location in patent: Page/Page column 70-71
[2] Patent: WO2011/20193, 2011, A1. Location in patent: Page/Page column 18-19
[3] Patent: WO2011/57382, 2011, A1. Location in patent: Page/Page column 21
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 5, p. 1953 - 1957

2-Bromo-4,5-difluorobenzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Bromo-4,5-difluorobenzaldehyde Suppliers

China 89 India 1 Switzerland 1 United Kingdom 3 United States 6 Global 100
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
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58
Aladdin Scientific
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Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
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58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
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View Lastest Price from 2-Bromo-4,5-difluorobenzaldehyde manufacturers

Career Henan Chemical Co
Product
2-Bromo-4,5-difluorobenzaldehyde 476620-54-9
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-02-17

476620-54-9, 2-Bromo-4,5-difluorobenzaldehydeRelated Search:


  • 2-Bromo-4,5-difluorobenzaldehyde
  • Benzaldehyde, 2-bromo-4,5-difluoro-
  • 2-Bromo-4,5-difluorobenzaldehyde,98%
  • 2-Bromo-4,5-difluorobenzaldehyde ISO 9001：2015 REACH
  • 5-difluorobenzaldehyde
  • 476620-54-9