6-Chloro-5-nitropyridine-2-carboxylic acid
- Product Name
- 6-Chloro-5-nitropyridine-2-carboxylic acid
- CAS No.
- 353277-27-7
- Chemical Name
- 6-Chloro-5-nitropyridine-2-carboxylic acid
- Synonyms
- 6-chloro-5-nitropicolinic acid;6-Chloro-5-nitropyridine-2-carboxylic acid;2-Pyridinecarboxylic acid, 6-chloro-5-nitro-;Benzo[b]thiophene-2-carboxylicacid,5,7-dimethoxy-,methylester
- CBNumber
- CB82506689
- Molecular Formula
- C6H3ClN2O4
- Formula Weight
- 202.55
- MOL File
- 353277-27-7.mol
6-Chloro-5-nitropyridine-2-carboxylic acid Property
- Boiling point:
- 413.6±45.0 °C(Predicted)
- Density
- 1.702±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 2.34±0.13(Predicted)
- Appearance
- Off-white to light green Solid
- InChI
- InChI=1S/C6H3ClN2O4/c7-5-4(9(12)13)2-1-3(8-5)6(10)11/h1-2H,(H,10,11)
- InChIKey
- WMPMXUCWDZXMEW-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)=NC(Cl)=C([N+]([O-])=O)C=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C612078
- Product name
- 6-Chloro-5-nitropicolinicAcid
- Packaging
- 10mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- HCH0196805
- Product name
- 6-CHLORO-5-NITROPYRIDINE-2-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.58
- Updated
- 2021/12/16
- Product number
- 3013AL
- Product name
- 6-Chloro-5-nitropicolinicacid
- Packaging
- 5g
- Price
- $1131
- Updated
- 2021/12/16
- Product number
- 3013AL
- Product name
- 6-Chloro-5-nitropicolinicacid
- Packaging
- 10g
- Price
- $1720
- Updated
- 2021/12/16
- Product number
- 353277277
- Product name
- 6-Chloro-5-nitropicolinicacid
- Packaging
- 10g
- Price
- $1824.47
- Updated
- 2021/12/16
6-Chloro-5-nitropyridine-2-carboxylic acid Chemical Properties,Usage,Production
Synthesis
56057-19-3
353277-27-7
General procedure for the synthesis of 6-chloro-5-nitro-2-pyridinecarboxylic acid from 6-chloro-5-nitro-2-methylpyridine: 6-chloro-5-nitro-2-methylpyridine (97 g, 560 mmol) was slowly added to a reaction flask pre-filled with 18 M sulfuric acid (400 mL) under stirring conditions. Subsequently, chromium trioxide (169 g, 1.69 mol) was added to the reaction mixture in small portions and the reaction temperature was controlled to be below 50 °C. The reaction mixture was stirred continuously at 15 °C for 20 hours. Upon completion of the reaction, the mixture was quenched by pouring it into 2 Kg of ice water and the resulting solid product was collected by filtration. The resulting solid was dried under vacuum to give 6-chloro-5-nitro-2-pyridinecarboxylic acid (103 g, 90% yield) as a pale white solid. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6) with chemical shifts of δ 8.70 (d, 1H), 8.24 (d, 1H).
References
[1] Patent: US2018/170908, 2018, A1. Location in patent: Paragraph 0429
[2] Patent: EP2366691, 2011, A1. Location in patent: Page/Page column 12
[3] Patent: WO2016/176460, 2016, A1. Location in patent: Page/Page column 114; 158
6-Chloro-5-nitropyridine-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
6-Chloro-5-nitropyridine-2-carboxylic acid Suppliers
- Tel
- +49 5662 408730
- Fax
- +49 5662 4087320
- info@synchem.de
- Country
- Germany
- ProdList
- 4705
- Advantage
- 70
View Lastest Price from 6-Chloro-5-nitropyridine-2-carboxylic acid manufacturers
- Product
- 6-Chloro-5-nitropyridine-2-carboxylic acid 353277-27-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2024-11-13