ChemicalBook > CAS DataBase List > 6-Chloro-5-nitropyridine-2-carboxylic acid

6-Chloro-5-nitropyridine-2-carboxylic acid

Product Name
6-Chloro-5-nitropyridine-2-carboxylic acid
CAS No.
353277-27-7
Chemical Name
6-Chloro-5-nitropyridine-2-carboxylic acid
Synonyms
6-chloro-5-nitropicolinic acid;6-Chloro-5-nitropyridine-2-carboxylic acid;2-Pyridinecarboxylic acid, 6-chloro-5-nitro-;Benzo[b]thiophene-2-carboxylicacid,5,7-dimethoxy-,methylester
CBNumber
CB82506689
Molecular Formula
C6H3ClN2O4
Formula Weight
202.55
MOL File
353277-27-7.mol
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6-Chloro-5-nitropyridine-2-carboxylic acid Property

Boiling point:
413.6±45.0 °C(Predicted)
Density 
1.702±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
2.34±0.13(Predicted)
Appearance
Off-white to light green Solid
InChI
InChI=1S/C6H3ClN2O4/c7-5-4(9(12)13)2-1-3(8-5)6(10)11/h1-2H,(H,10,11)
InChIKey
WMPMXUCWDZXMEW-UHFFFAOYSA-N
SMILES
C1(C(O)=O)=NC(Cl)=C([N+]([O-])=O)C=C1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C612078
Product name
6-Chloro-5-nitropicolinicAcid
Packaging
10mg
Price
$65
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0196805
Product name
6-CHLORO-5-NITROPYRIDINE-2-CARBOXYLIC ACID
Purity
95.00%
Packaging
5MG
Price
$505.58
Updated
2021/12/16
AK Scientific
Product number
3013AL
Product name
6-Chloro-5-nitropicolinicacid
Packaging
5g
Price
$1131
Updated
2021/12/16
AK Scientific
Product number
3013AL
Product name
6-Chloro-5-nitropicolinicacid
Packaging
10g
Price
$1720
Updated
2021/12/16
Alichem
Product number
353277277
Product name
6-Chloro-5-nitropicolinicacid
Packaging
10g
Price
$1824.47
Updated
2021/12/16
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6-Chloro-5-nitropyridine-2-carboxylic acid Chemical Properties,Usage,Production

Synthesis

56057-19-3

353277-27-7

General procedure for the synthesis of 6-chloro-5-nitro-2-pyridinecarboxylic acid from 6-chloro-5-nitro-2-methylpyridine: 6-chloro-5-nitro-2-methylpyridine (97 g, 560 mmol) was slowly added to a reaction flask pre-filled with 18 M sulfuric acid (400 mL) under stirring conditions. Subsequently, chromium trioxide (169 g, 1.69 mol) was added to the reaction mixture in small portions and the reaction temperature was controlled to be below 50 °C. The reaction mixture was stirred continuously at 15 °C for 20 hours. Upon completion of the reaction, the mixture was quenched by pouring it into 2 Kg of ice water and the resulting solid product was collected by filtration. The resulting solid was dried under vacuum to give 6-chloro-5-nitro-2-pyridinecarboxylic acid (103 g, 90% yield) as a pale white solid. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6) with chemical shifts of δ 8.70 (d, 1H), 8.24 (d, 1H).

References

[1] Patent: US2018/170908, 2018, A1. Location in patent: Paragraph 0429
[2] Patent: EP2366691, 2011, A1. Location in patent: Page/Page column 12
[3] Patent: WO2016/176460, 2016, A1. Location in patent: Page/Page column 114; 158

6-Chloro-5-nitropyridine-2-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Chloro-5-nitropyridine-2-carboxylic acid Suppliers

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View Lastest Price from 6-Chloro-5-nitropyridine-2-carboxylic acid manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
6-Chloro-5-nitropyridine-2-carboxylic acid 353277-27-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2024-11-13

353277-27-7, 6-Chloro-5-nitropyridine-2-carboxylic acidRelated Search:

2-chloro-3-nitro-6-hydroxypyridine 2-Chloro-3-nitropyridine-6-amine

  • 2-Pyridinecarboxylic acid, 6-chloro-5-nitro-
  • 6-Chloro-5-nitropyridine-2-carboxylic acid
  • 6-chloro-5-nitropicolinic acid
  • Benzo[b]thiophene-2-carboxylicacid,5,7-dimethoxy-,methylester
  • 353277-27-7