3-bromo-5-fluoroisonicotinaldehyde
- Product Name
- 3-bromo-5-fluoroisonicotinaldehyde
- CAS No.
- 1227573-02-5
- Chemical Name
- 3-bromo-5-fluoroisonicotinaldehyde
- Synonyms
- 3-bromo-5-fluoroisonicotinaldehyde;3-Bromo-5-fluoro-pyridine-4-carbaldehyde;3-Bromo-5-fluoropyridine-4-carboxaldehyde;4-Pyridinecarboxaldehyde, 3-broMo-5-fluoro-
- CBNumber
- CB82512811
- Molecular Formula
- C6H3BrFNO
- Formula Weight
- 204
- MOL File
- 1227573-02-5.mol
3-bromo-5-fluoroisonicotinaldehyde Property
- Boiling point:
- 227.5±35.0 °C(Predicted)
- Density
- 1.778±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.54±0.28(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B679473
- Product name
- 3-Bromo-5-fluoroisonicotinaldehyde
- Packaging
- 10g
- Price
- $580
- Updated
- 2021/12/16
- Product number
- 4H15-B-03
- Product name
- 3-Bromo-5-fluoropyridine-4-carbaldehyde
- Purity
- 97%
- Packaging
- 250mg
- Price
- $643
- Updated
- 2021/12/16
- Product number
- Y3893
- Product name
- 3-Bromo-5-fluoropyridine-4-carboxaldehyde
- Packaging
- 5g
- Price
- $757
- Updated
- 2021/12/16
- Product number
- 4H15-B-03
- Product name
- 3-Bromo-5-fluoropyridine-4-carbaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $1734
- Updated
- 2021/12/16
- Product number
- Y15208
- Product name
- 3-Bromo-5-fluoroisonicotinaldehyde
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
3-bromo-5-fluoroisonicotinaldehyde Chemical Properties,Usage,Production
Synthesis
407-20-5
68-12-2
1227573-02-5
1. diisopropylamine (5.7 g, 28.4 mmol, 2.0 eq.) was dissolved in anhydrous tetrahydrofuran (200.0 mL), and the reaction system was cooled to -60°C to -65°C. The reaction system was then cooled to -60°C to -65°C. The reaction system was then cooled to -60°C to -65°C, and the reaction system was cooled to -65°C. 2. n-Butyllithium (35.5 mL, 56.8 mmol, 2.0 eq.) was slowly added dropwise to the above solution with stirring. 3. maintain the temperature at -60°C to -65°C and continue to stir the reaction mixture for 30 minutes. 4. Slowly add a solution of 3-bromo-5-fluoropyridine (5.0 g, 28.4 mmol, 1.0 eq.) in anhydrous tetrahydrofuran (50.0 mL) at the same temperature and stir for 30 min. 5. N,N-dimethylformamide (2.5 g, 34.1 mmol, 1.2 eq.) was added in a single addition and stirred at -60°C to -65°C for 30 min. 6. Upon completion of the reaction, the reaction was quenched with methanol followed by the addition of an aqueous ammonium chloride solution. 7. The reaction mixture was diluted with ethyl acetate (200.0 mL) and extracted with ethyl acetate (200.0 mL × 3). 8. The organic phases were combined, washed with saturated saline and concentrated under reduced pressure. 9. The residue was purified by column chromatography (petroleum ether: ethyl acetate = 3:1) to give 3-bromo-5-fluoroisonicotinaldehyde (3.5 g, 60.3% yield) as a brown oil. 10. The product was analyzed by liquid chromatography-mass spectrometry (LCMS) with a calculated (M + H+) m/z of 204.1 and a measured value of 204.2.
References
[1] Patent: WO2018/11628, 2018, A1. Location in patent: Paragraph 00661
[2] Patent: US2018/111932, 2018, A1. Location in patent: Paragraph 0406; 0407
[3] Patent: WO2010/130773, 2010, A2. Location in patent: Page/Page column 77-78
[4] Patent: WO2011/61168, 2011, A1. Location in patent: Page/Page column 61
3-bromo-5-fluoroisonicotinaldehyde Preparation Products And Raw materials
Raw materials
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View Lastest Price from 3-bromo-5-fluoroisonicotinaldehyde manufacturers
- Product
- 3-bromo-5-fluoroisonicotinaldehyde 1227573-02-5
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-18