AC-55541

Product Name: AC-55541
CAS No.: 916170-19-9
Chemical Name: AC-55541
Synonyms: AOB2796;CS-1802;CS-2020;AC 55541;AC55541; AC-55541;AC 55541,inhibit,AC-55541,AC55541,Inhibitor,Protease Activated Receptor (PAR),Thrombin receptors;(2E)-2-[1-(3-Bromophenyl)ethylidene]α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineaceticacidhydrazide;1-Phthalazineacetic acid, α-(benzoylamino)-3,4-dihydro-4-oxo-, (2E)-2-[1-(3-bromophenyl)ethylidene]hydrazide;alpha-(Benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineacetic acid (2E)-2-[1-(3-bromophenyl)ethylidene]hydrazide;N-({N'-[(1E)-1-(3-bromophenyl)ethylidene]hydrazinecarbonyl}(4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzamide
CBNumber: CB82518974
Molecular Formula: C25H20BrN5O3
Formula Weight: 518.36
MOL File: 916170-19-9.mol

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AC-55541 Property

Density: 1.49±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Soluble in DMSO
form: powder
pka: 10.99±0.46(Predicted)
color: White to off-white

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Safety

WGK Germany: 1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A3609
Product name: AC-55541
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $177
Updated: 2022/05/15

Cayman Chemical

Product number: 17736
Product name: AC-55541
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 17736
Product name: AC-55541
Purity: ≥98%
Packaging: 5mg
Price: $130
Updated: 2024/03/01

Cayman Chemical

Product number: 17736
Product name: AC-55541
Purity: ≥98%
Packaging: 10mg
Price: $214
Updated: 2024/03/01

Cayman Chemical

Product number: 17736
Product name: AC-55541
Purity: ≥98%
Packaging: 25mg
Price: $479
Updated: 2024/03/01

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AC-55541 Chemical Properties,Usage,Production

Uses

AC 55541 is a selective protease-activated receptor 2 agonist.

Definition

ChEBI: AC-55541 is an organic molecular entity.

Biological Activity

ac 55541 is a potent agonist of par2 with pec50 value of 6.7 and functions range from 200 to 1000 nm [1-3].protease-activated receptor 2 (par2) is a member of the large family of 7-transmembrane receptors and plays an important role in modulating inflammatory responses and acting as a sensor for proteolytic enzymes generated during infection [2].ac 55541 is a selective par2 agonist and has no effect on par1. using a cellular proliferation assay (r-sat), it showed that ac 55541 stimulated nih-3t3 cells proliferation by activating par2 and receptor with f240s mutation constitutively active in all functional assays which nearly 30-fold sensitive to ac 55541 than sligrl and 2-furorl ligrlo [1, 2]. when tested with human corneal epithelial (hce) cells, administration of ac 55541 significantly induced the expression of par2 and inhibited acanthamoeba plasminogen activator (apa) [3].in male sprague-dawley rat model with acute thermal nociception and edema in paw induced by sligrl-nh2 or trypsin, intrapaw administration of ac 55541 induced hind paw edema and thermal hyperalgesia at the doses as low as 30 ng and showed dose-dependent pronociceptive effects [1].

storage

Store at -20°C

References

1. gardell, l.r., et al., identification and characterization of novel small-molecule protease-activated receptor 2 agonists. j pharmacol exp ther, 2008. 327(3): p. 799-808.2. ma, j.n. and e.s. burstein, the protease activated receptor 2 (par2) polymorphic variant f240s constitutively activates par2 receptors and potentiates responses to small-molecule par2 agonists. j pharmacol exp ther, 2013. 347(3): p. 697-704.3. tripathi, t., m. abdi, and h. alizadeh, protease-activated receptor 2 (par2) is upregulated by acanthamoeba plasminogen activator (apa) and induces proinflammatory cytokine in human corneal epithelial cells. invest ophthalmol vis sci, 2014. 55(6): p. 3912-21.

AC-55541 Preparation Products And Raw materials

Raw materials

Preparation Products

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AC-55541 Suppliers

China 57 India 1 United Kingdom 2 United States 15 Global 75

Novachemistry

Tel: 44-20819178-90 02081917890
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Tocris Bioscience

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916170-19-9, AC-55541Related Search:

AC710 AMG319

(2E)-2-[1-(3-Bromophenyl)ethylidene]α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineaceticacidhydrazide

AC 55541

CS-2020

CS-1802

AC 55541,(2E)-2-[1-(3-Bromophenyl)ethylidene]α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineaceticacidhydrazide

(E)-N-(2-(2-(1-(3-Bromophenyl)ethylidene)hydrazinyl)-2-oxo-1-(4-oxo-3,4-dihydrophthalazin-1-yl)ethyl)benzamide

AC55541; AC-55541

(2E)-2-[1-(3-Bromophenyl)ethylidene] α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineacetic acid hydrazide AC55541

AOB2796

alpha-(Benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineacetic acid (2E)-2-[1-(3-bromophenyl)ethylidene]hydrazide

1-Phthalazineacetic acid, α-(benzoylamino)-3,4-dihydro-4-oxo-, (2E)-2-[1-(3-bromophenyl)ethylidene]hydrazide

AC 55541,inhibit,AC-55541,AC55541,Inhibitor,Protease Activated Receptor (PAR),Thrombin receptors

(E)-N-(2-(2-(1-(3-Bromophenyl)ethylidene)hydrazineyl)-2-oxo-1-(4-oxo-3,4-dihydrophthalazin-1-yl)ethyl)benzamide

N-({N'-[(1E)-1-(3-bromophenyl)ethylidene]hydrazinecarbonyl}(4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzamide

916170-19-9

C25H20BrN5O3

Inhibitors