Paliperidone Palmitate
- Product Name
- Paliperidone Palmitate
- CAS No.
- 199739-10-1
- Chemical Name
- Paliperidone Palmitate
- Synonyms
- Invega Sustenna;RO 92670;Paliperidone Palmitate;Paliperidone Palmitate-d31;Paliperidone Palmitate [USAN];9-Hydroxyrisperidone palmitate;Palmitone Palmitate Impurity 4;Palmitone Palmitate Impurity 6;Palmitone Palmitate Impurity 3;Palmitone Palmitate Impurity 2
- CBNumber
- CB82519012
- Molecular Formula
- C39H57FN4O4
- Formula Weight
- 664.89
- MOL File
- 199739-10-1.mol
Paliperidone Palmitate Property
- Melting point:
- 110-115°C
- Boiling point:
- 736.3±70.0 °C(Predicted)
- Density
- 1.19
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly, Heated, Sonicated), Methanol (Slightly)
- form
- Solid
- pka
- 8.07±0.10(Predicted)
- color
- Off-White to Light Beige
- InChIKey
- VOMKSBFLAZZBOW-UHFFFAOYSA-N
- SMILES
- C(OC1C2N(CCC1)C(=O)C(CCN1CCC(C3C4=C(ON=3)C=C(F)C=C4)CC1)=C(C)N=2)(=O)CCCCCCCCCCCCCCC
Safety
- WGK Germany
- WGK 3
- Storage Class
- 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects - Hazard Classifications
- Acute Tox. 3 Oral
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- P2967
- Product name
- Paliperidone Palmitate
- Packaging
- 100MG
- Price
- $52
- Updated
- 2026/03/19
- Product number
- P2967
- Product name
- Paliperidone Palmitate
- Packaging
- 1G
- Price
- $306
- Updated
- 2026/03/19
- Product number
- P141020
- Product name
- PaliperidonePalmitate
- Packaging
- 500mg
- Price
- $210
- Updated
- 2021/12/16
- Product number
- AS148096
- Product name
- PaliperidonePalmitate
- Purity
- 98%
- Packaging
- 250mg
- Price
- $233
- Updated
- 2021/12/16
- Product number
- API0027470
- Product name
- PALIPERIDONE PALMITATE
- Purity
- 95.00%
- Packaging
- 25MG
- Price
- $750.75
- Updated
- 2021/12/16
Paliperidone Palmitate Chemical Properties,Usage,Production
Description
Paliperidone palmitate is an atypical long acting antipsychotics，which can fast onset in acute phase and continuously improve the symptoms in maintenance phase． It has the solid efficacy and convenient ad[1]ministration，which offer a new option for schizophrenia treatment and will help patients to adhere the treatment and prevent relapse． As the sole long acting antipsychotics with monthly injection，it was approved by CFDA in 2011 and indicated for the acute and maintenance treatment of schizophrenia．
Uses
Paliperidone Palmitate is a long-acting injectable atypical antipsychotic used in the treatment of schizophrenia.
Definition
ChEBI: 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-9-yl hexadecanoate is a fatty acid ester obtained by the formal condensation of the carboxy group of hexadecanoic acid with the hydroxy group of 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one. It is a member of 1,2-benzoxazoles, a heteroarylpiperidine, an organofluorine compound, a pyridopyrimidine and a fatty acid ester.
Side effects
The review of the literature also underlined that paliperidone palmitate is well tolerated, compared with placebo. Frequency and severity of side-effects such as extrapyramidal symptoms, hyperprolactinemia and weight gain, was similar or less than those found in treatment with other atypical antipsychotics, including long-acting ones.
Synthesis
Aseptic air-flow mill was used to control the crushing pressure of 3~5bar, and the sterile paliperidone palmitate was crushed to the effective particle size of 2~15μm. Weighed 12g of sodium carboxymethyl cellulose, placed in about 500ml of injectable water, dissolved, dissolved; and then took 15g of injectable polysorbate 80, 40g of mannitol, 0.9g of sodium dihydrogen phosphate, stirred to dissolve, and then adjust the pH value to 7.0 by using 0.5 M sodium hydroxide solution to adjust the pH to 7.0. Weigh 312g of micronized sterile papanicolone palmitate was added to the above solution, stirred and sheared until uniformly dispersed, replenished with water for injection, and the volume of the material was fixed to 1000 ml, to obtain the aseptic papanicolone palmitate suspension with an effective particle size in the range of 2~15μm.
Paliperidone Palmitate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Paliperidone Palmitate manufacturers
- Product
- Paliperidone Palmitate 199739-10-1
- Price
- US $0.00/g
- Min. Order
- 100g
- Purity
- 98.0%
- Supply Ability
- 50kg/month
- Release date
- 2021-07-23
- Product
- Paliperidone Palmitate 199739-10-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-06
- Product
- Paliperidone Palmitate 199739-10-1
- Price
- US $0.00-0.00/Kg/Bag
- Min. Order
- 1Kg/Bag
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2024-06-27