Methyl 4-chloro-3-methoxy-5-nitrobenzenecarboxylate
- Product Name
- Methyl 4-chloro-3-methoxy-5-nitrobenzenecarboxylate
- CAS No.
- 63603-09-8
- Chemical Name
- Methyl 4-chloro-3-methoxy-5-nitrobenzenecarboxylate
- Synonyms
- Methyl 4-chloro-3-methoxy-5-nitrobenzoate;BENZENE DERIVATIVE63603-09-8;methyl 3-nitro-4-chloro-5-methoxybenzoate;2-Chloro-5-(methoxycarbonyl)-3-nitroanisole;Methyl 4-chloro-3-methoxy-5-nitrobenzoate 95+%;Benzeneaceticacid,6-bromo-α-formyl-,ethylester;2-chloro-1-methoxy-5-(methylperoxy)-3-nitrobenzene;4-chloro-3-methoxy-5-nitroBenzoic acid methyl ester;Methyl 4-chloro-3-methoxy-5-nitrobenzenecarboxylate;Benzoic acid, 4-chloro-3-methoxy-5-nitro-, methyl ester
- CBNumber
- CB82528290
- Molecular Formula
- C9H8ClNO5
- Formula Weight
- 245.62
- MOL File
- 63603-09-8.mol
Methyl 4-chloro-3-methoxy-5-nitrobenzenecarboxylate Property
- Boiling point:
- 366.2±37.0 °C(Predicted)
- Density
- 1.402±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- crystalline powder
- color
- Beige to light brown
- InChI
- InChI=1S/C9H8ClNO5/c1-15-7-4-5(9(12)16-2)3-6(8(7)10)11(13)14/h3-4H,1-2H3
- InChIKey
- QNYHMMOXMRPWTK-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC([N+]([O-])=O)=C(Cl)C(OC)=C1
Safety
- HazardClass
- IRRITANT
- HS Code
- 2922500090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M295380
- Product name
- Methyl4-Chloro-3-methoxy-5-nitrobenzoate
- Packaging
- 500mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- M295380
- Product name
- Methyl4-Chloro-3-methoxy-5-nitrobenzoate
- Packaging
- 2.5g
- Price
- $470
- Updated
- 2021/12/16
- Product number
- HCH0369417
- Product name
- METHYL-4-CHLORO-3-METHOXY-5-NITROBENZENECARBOXYLATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $598.12
- Updated
- 2021/12/16
- Product number
- 9709AB
- Product name
- Methyl4-chloro-3-methoxy-5-nitrobenzenecarboxylate
- Packaging
- 10g
- Price
- $601
- Updated
- 2021/12/16
- Product number
- 4654-5-Y6
- Product name
- Methyl 4-chloro-3-methoxy-5-nitrobenzoate
- Purity
- 95.0%
- Packaging
- 25g
- Price
- $992
- Updated
- 2021/12/16
Methyl 4-chloro-3-methoxy-5-nitrobenzenecarboxylate Chemical Properties,Usage,Production
Uses
Methyl 4-Chloro-3-methoxy-5-nitrobenzoate is a reagent in the formal total synthesis of N-methylmaysenine.
Synthesis
42590-00-1
63603-09-8
Step (ii): synthesis of methyl 4-chloro-3-methoxy-5-nitrobenzoate (3) Methyl 4-hydroxy-3-methoxy-5-nitrobenzoate (2) (4.4 g, 19 mmol) was dissolved in DMF (30 mL) at 0 °C and oxalyl chloride (5.09 mL, 58.1 mmol) was added dropwise. The reaction mixture was stirred at 80 °C for 3 h under the protection of a CaCl2 drying tube. After completion of the reaction, the mixture was cooled to room temperature, slowly poured into ice water (100 mL) and stirred for 15 minutes. The precipitate was collected by filtration and washed sequentially with water and methanol to afford methyl 4-chloro-3-methoxy-5-nitrobenzoate (3) as a yellow solid (3.2 g, 65% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 8.04 (1H, d), 7.77 (1H, d), 4.04 (3H, s), 3.97 (3H, s).
References
[1] Organic Letters, 2009, vol. 11, # 8, p. 1809 - 1812
[2] Journal of the American Chemical Society, 1983, vol. 105, # 15, p. 5015 - 5024
[3] Patent: WO2011/27106, 2011, A1. Location in patent: Page/Page column 152
[4] Patent: US2012/149737, 2012, A1. Location in patent: Page/Page column 89
Methyl 4-chloro-3-methoxy-5-nitrobenzenecarboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 4-chloro-3-methoxy-5-nitrobenzenecarboxylate manufacturers
- Product
- Methyl 4-chloro-3-methoxy-5-nitrobenzenecarboxylate 63603-09-8
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 96%-98%
- Supply Ability
- 10000KGS
- Release date
- 2019-12-26