6-Chloro-5-methoxy-nicotinic acid methyl ester

Product Name: 6-Chloro-5-methoxy-nicotinic acid methyl ester
CAS No.: 915107-31-2
Chemical Name: 6-Chloro-5-methoxy-nicotinic acid methyl ester
Synonyms: Methyl 6-chloro-5-Methoxynicotinate;6-Chloro-5-methoxy-nicotinic acid methyl ester;Methyl 6-chloro-5-Methoxypyridine-3-carboxylate;3-Pyridinecarboxylic acid, 6-chloro-5-methoxy-, methyl ester;Methyl 6-chloro-5-methoxypyridine-3-carboxylate, 2-Chloro-3-methoxy-5-(methoxycarbonyl)pyridine
CBNumber: CB82535434
Molecular Formula: C8H8ClNO3
Formula Weight: 201.61
MOL File: 915107-31-2.mol

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6-Chloro-5-methoxy-nicotinic acid methyl ester Property

Melting point:: 99-100 °C
Boiling point:: 280.9±35.0 °C(Predicted)
Density: 1.288±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -2.89±0.10(Predicted)
form: powder
color: Yellow
InChI: InChI=1S/C8H8ClNO3/c1-12-6-3-5(8(11)13-2)4-10-7(6)9/h3-4H,1-2H3
InChIKey: XPHMEWSKODAWPT-UHFFFAOYSA-N
SMILES: C1=NC(Cl)=C(OC)C=C1C(OC)=O

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: M342765
Product name: Methyl6-chloro-5-methoxynicotinate
Packaging: 100mg
Price: $175
Updated: 2021/12/16

Apolloscientific

Product number: OR46512
Product name: Methyl6-chloro-5-methoxynicotinate
Packaging: 500mg
Price: $414
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-5-X1
Product name: Methyl 6-chloro-5-methoxynicotinate
Packaging: 500mg
Price: $456
Updated: 2021/12/16

Matrix Scientific

Product number: 188044
Product name: Methyl 6-chloro-5-methoxypyridine-3-carboxylate
Packaging: 1g
Price: $466
Updated: 2021/12/16

AK Scientific

Product number: 5376AC
Product name: Methyl6-chloro-5-methoxynicotinate
Packaging: 5g
Price: $724
Updated: 2021/12/16

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6-Chloro-5-methoxy-nicotinic acid methyl ester Chemical Properties,Usage,Production

Synthesis

915107-30-1

74-88-4

915107-31-2

The reaction was carried out in acetone (190 mL) at reflux for 6 hours with methyl 6-chloro-5-hydroxynicotinate (1.8 g, 9.6 mmol), iodomethane (2M ether solution, 5.8 mL, 11.6 mmol) and potassium carbonate (2.0 g, 14.5 mmol). Upon completion of the reaction, the reaction mixture was concentrated using a rotary evaporator and subsequently diluted by adding water (100 mL). The resulting white precipitate was collected by filtration and washed with additional water to afford the target product methyl 6-chloro-5-methoxynicotinate as a white solid (1.33 g, 68% yield) with a melting point of 83-85 °C. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3) δ 8.60 (d, 1H), 7.77 (d, 1H), 3.98 (s, 3H), 3.96 (s, 3H) and GC-MS (calculated value: C8H8ClNO3 [M]+ 201, measured value: 201).

References

[1] Patent: US2009/131468, 2009, A1. Location in patent: Page/Page column 66
[2] Patent: WO2009/64251, 2009, A1. Location in patent: Page/Page column 140
[3] Patent: US2008/108667, 2008, A1. Location in patent: Page/Page column 10
[4] Patent: US2016/376283, 2016, A1. Location in patent: Paragraph 0493; 0495
[5] Patent: WO2011/48525, 2011, A1. Location in patent: Page/Page column 44

6-Chloro-5-methoxy-nicotinic acid methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Chloro-5-methoxy-nicotinic acid methyl ester Suppliers

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915107-31-2, 6-Chloro-5-methoxy-nicotinic acid methyl esterRelated Search:

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6-Chloro-5-methoxy-nicotinic acid methyl ester

Methyl 6-chloro-5-Methoxypyridine-3-carboxylate

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915107-31-2