ChemicalBook > CAS DataBase List > 6-Chloro-4-methoxypyridine-3-carbaldehyde

6-Chloro-4-methoxypyridine-3-carbaldehyde

Product Name
6-Chloro-4-methoxypyridine-3-carbaldehyde
CAS No.
1256823-05-8
Chemical Name
6-Chloro-4-methoxypyridine-3-carbaldehyde
Synonyms
6-Chloro-4-methoxynicotinaldehyde;6-Chloro-4-methoxypyridine-3-carbaldehyde;6-Chloro-4-methoxy-3-pyridinecarboxaldehyde;3-Pyridinecarboxaldehyde, 6-chloro-4-methoxy-
CBNumber
CB12692022
Molecular Formula
C7H6ClNO2
Formula Weight
171.58
MOL File
1256823-05-8.mol
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6-Chloro-4-methoxypyridine-3-carbaldehyde Property

Boiling point:
301.9±37.0 °C(Predicted)
Density 
1.317±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
0.26±0.10(Predicted)
form 
powder
color 
White
InChI
InChI=1S/C7H6ClNO2/c1-11-6-2-7(8)9-3-5(6)4-10/h2-4H,1H3
InChIKey
MJKBQIXGOHBBFO-UHFFFAOYSA-N
SMILES
C1=NC(Cl)=CC(OC)=C1C=O
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Frontier Specialty Chemicals
Product number
C15678
Product name
6-Chloro-4-methoxypyridine-3-carbaldehyde
Purity
98%
Packaging
250mg
Price
$95
Updated
2021/12/16
Matrix Scientific
Product number
087234
Product name
6-Chloro-4-methoxypyridine-3-carbaldehyde
Purity
>97%
Packaging
500mg
Price
$421
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
C15678
Product name
6-Chloro-4-methoxypyridine-3-carbaldehyde
Purity
98%
Packaging
1g
Price
$280
Updated
2021/12/16
Matrix Scientific
Product number
087234
Product name
6-Chloro-4-methoxypyridine-3-carbaldehyde
Purity
>97%
Packaging
1g
Price
$647
Updated
2021/12/16
Apolloscientific
Product number
OR303071
Product name
6-Chloro-4-methoxypyridine-3-carbaldehyde
Packaging
1g
Price
$943
Updated
2021/12/16
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6-Chloro-4-methoxypyridine-3-carbaldehyde Chemical Properties,Usage,Production

Synthesis

1060811-62-2

124-41-4

1256823-05-8

Sodium methanolate (0.068 g, 1.25 mmol) was added batchwise to a stirred solution of 4,6-dichloropyridine-3-carbaldehyde (0.2 g, 1.14 mmol) in methanol (10 mL) at 0 °C. The reaction mixture was slowly warmed to room temperature (about 5 hours) and stirring was continued at room temperature for 16 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the residue was dissolved in dichloromethane. Insoluble solids were removed by filtration and the filtrate was purified by fast silica gel column chromatography with an elution gradient of 0 to 50% ethyl acetate in heptane solution. The purified grades were collected and concentrated under reduced pressure to give 6-chloro-4-methoxynicotinaldehyde (0.111 g, 57% yield) as a white solid.1H NMR (500 MHz, CDCl3, 22 °C) δ 4.02 (3H, s), 6.97 (1H, s), 8.69 (1H, s), 10.37 (1H, d). Mass spectrum (ESI+): m/z 172 [M+H]+.

References

[1] Patent: WO2018/19793, 2018, A1. Location in patent: Page/Page column 126; 127

6-Chloro-4-methoxypyridine-3-carbaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Chloro-4-methoxypyridine-3-carbaldehyde Suppliers

China 42 India 1 United Kingdom 1 United States 5 Global 49
Suzhou Crst Pharmatech Co., Ltd.
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Aikon International Limited
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Jinan chemkey pharmaceutical Co., Ltd.
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1256823-05-8, 6-Chloro-4-methoxypyridine-3-carbaldehydeRelated Search:

6-CHLORO-4-METHOXY-PYRIDINE-2-CARBOXYLIC ACID 6-Chloro-5-fluoro-2,3-dihydro-1H-inden-1-one 3-Pyridinecarboxylic acid, 6-chloro-4-methoxy-, methyl ester 6-Chloro-5-methoxy-nicotinic acid methyl ester 6-CHLORO-4-METHYL-1-INDANONE NSC45719 4-(2-Pyridinyl)benzaldehyde

  • 6-Chloro-4-methoxypyridine-3-carbaldehyde
  • 6-Chloro-4-methoxynicotinaldehyde
  • 6-Chloro-4-methoxy-3-pyridinecarboxaldehyde
  • 3-Pyridinecarboxaldehyde, 6-chloro-4-methoxy-
  • 1256823-05-8