AS 1269574
- Product Name
- AS 1269574
- CAS No.
- 330981-72-1
- Chemical Name
- AS 1269574
- Synonyms
- AS126957;AS 1269574;AS-1269574 (AS1269574);2-(2-(4-Bromophenyl)-6-methylpyrimidin-4-ylamino)ethanol;2-[[2-(4-BroMophenyl)-6-Methyl-4-pyrinidinyl]aMino]ethanol;2-[[2-(4-Bromophenyl)-6-methyl-4-pyrimidinyl]amino]ethanol;Ethanol, 2-[[2-(4-bromophenyl)-6-methyl-4-pyrimidinyl]amino]-;TRP Channel,G Protein-Coupled Receptor 119,secretion,Inhibitor,type,AS1269574,cation,diabetes,insulin,inhibit,Transient receptor potential channels,glucose,GPR119,channels,AS-1269574
- CBNumber
- CB82535661
- Molecular Formula
- C13H14BrN3O
- Formula Weight
- 308.17
- MOL File
- 330981-72-1.mol
AS 1269574 Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- solution in ethanol
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 371724
- Product name
- GPR119 Agonist, AS1269574
- Purity
- The GPR119 Agonist, AS1269574, also referenced under CAS 330981-72-1, controls the biological activity of GPR119. This small molecule/inhibitor is primarily used for Biochemicals applications.
- Packaging
- 10MG
- Price
- $166
- Updated
- 2024/03/01
- Product number
- 10626
- Product name
- AS-1269574
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 10626
- Product name
- AS-1269574
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 10626
- Product name
- AS-1269574
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $117
- Updated
- 2024/03/01
- Product number
- 10626
- Product name
- AS-1269574
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $257
- Updated
- 2024/03/01
AS 1269574 Chemical Properties,Usage,Production
Uses
Acts as an orally available agonist of GPR119 (G-protein coupled receptor 119), a regulator of incretin and insulin hormone secretion.
Biological Activity
as 1269574,(2-[2-(4-bromophenyl)-6-methylpyrimidin-4-yl] amino ethanol), was capable of inducing glucose-stimulated insulin secretion (gsis) and improved glucose tolerance in normal mice. as 1269574 is an agonist of gpr119 with ec50 value of 2.5 μm [1] [2].gpr119 is highly expressed in pancreatic β-cells. this receptor enhances the effect of gsis via the elevation of intracellular camp concentrations [2].treated with either 1 or 10 μm as 1269574 for 20 min, the insulin secretion of mouse pancreatic min-6 β-cells pre-exposed to 16.8 mm glucose was significantly increased compared with the dmso vehicle control. in contrast, as 1269574 did not affect the insulin release of min-6 cells previously treated with low-glucose (2.8 mm) [2].in normal mice, a single treatment with 100 mg/kg of as 1269574 significantly reduced the area under the curve (auc) after 2 h (auc0-2h) of blood glucose. as 1269574 significantly increase the plasma insulin auc0-2h in mice compared with the vehicle control. a single oral administration of 100 mg/kg as 1269574 did not significantly lower the blood glucose auc in either fasted or fed mice, indicating as 1269574 did not have a hypoglycemic effect [2].
References
[1]. shigeru yoshida, hirotsugu tanaka, hiroyuki oshima, et al. as1907417, a novel gpr119 agonist, as an insulinotropic and β-cell preservative agent for the treatment of type 2 diabetes. biochemical and biophysical research communications, 2010, 400: 745-751.
[2]. shigeru yoshida, takahide ohishi, tetsuo matsui, et al. identification of a novel gpr119 agonist, as1269574, with in vitro and in vivo glucose-stimulated insulin secretion. biochemical and biophysical research communications, 2010, 400: 437-441.
AS 1269574 Preparation Products And Raw materials
Raw materials
Preparation Products
AS 1269574 Suppliers
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