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JNJ 5207852 dihydrochloride

Product Name
JNJ 5207852 dihydrochloride
CAS No.
398473-34-2
Chemical Name
JNJ 5207852 dihydrochloride
Synonyms
JNJ 5207852;JNJ-5207852, 10 mM in DMSO;JNJ 5207852 dihydrochloride;1-(4-(3-piperidin-1-ylpropoxy)benzyl)piperidine;1-{3-[4-(PIPERIDIN-1-YLMETHYL)PHENOXY]PROPYL}PIPERIDINE;Piperidine, 1-[3-[4-(1-piperidinylmethyl)phenoxy]propyl]-;1-[3-[4-(1-Piperidinylmethyl)phenoxy]propyl]piperidine hydrochloride;sleep,low,JNJ5207852,Histamine Receptor,JNJ-5207852,JNJ 5207852,Inhibitor,REM,toxicity,inhibit
CBNumber
CB82535676
Molecular Formula
C20H32N2O
Formula Weight
316.48
MOL File
398473-34-2.mol
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JNJ 5207852 dihydrochloride Property

Boiling point:
443.4±30.0 °C(Predicted)
Density 
1.032±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO : 77.5 mg/mL (244.88 mM; Need ultrasonic)
form 
Powder
pka
9.70±0.10(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
11998
Product name
JNJ-5207852
Purity
≥98%
Packaging
5mg
Price
$89
Updated
2024/03/01
Cayman Chemical
Product number
11998
Product name
JNJ-5207852
Purity
≥98%
Packaging
10mg
Price
$168
Updated
2024/03/01
Cayman Chemical
Product number
11998
Product name
JNJ-5207852
Purity
≥98%
Packaging
50mg
Price
$700
Updated
2024/03/01
Tocris
Product number
4020
Product name
JNJ5207852dihydrochloride
Purity
≥99%(HPLC)
Packaging
10
Price
$195
Updated
2021/12/16
Tocris
Product number
4020
Product name
JNJ5207852dihydrochloride
Purity
≥99%(HPLC)
Packaging
50
Price
$772
Updated
2021/12/16
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JNJ 5207852 dihydrochloride Chemical Properties,Usage,Production

Uses

JNJ 5207852 is a Histamine H3 Receptor antagonist, used in the treatment of obesity.

in vivo

JNJ-5207852 (1-10mg/kg s.c.) increases time spent awake and decreases REM sleep and slow-wave sleep, but fails to have an effect on wakefulness or sleep in H3 receptor knockout mice. The wake promoting effects of this H3 receptor antagonist are not associated with hypermotility. A 4-week daily treatment of mice with JNJ-5207852 (10 mg/kg i.p.) does not lead to a change in body weight. JNJ-5207852 is extensively absorbed after oral administration and reaches high brain levels[1].

Animal Model:Male, Sprague-Dawley rats weighing 282-334 g[1].
Dosage:3, 10, 30 mg/kg.
Administration:S.C.
Result:Iincreased time spent awake and decreased REM sleep and slow-wave sleep.

IC 50

H3 receptor: 8.9 (pKi, for rat); H3 receptor: 9.24 (pKi, for human)

JNJ 5207852 dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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JNJ 5207852 dihydrochloride Suppliers

China 72 India 1 United Kingdom 1 United States 8 Global 82
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8065
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58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
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55
Guangzhou Zhiya Chemdrugs Co.,Ltd
Tel
18122150900
Fax
QQ:2869377561
Email
sculk28@163.com
Country
China
ProdList
646
Advantage
55
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
8011
Advantage
55
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9125
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Chuzhou KeMail Chemical Technology Co., Ltd
Tel
0550-5196001 15000891977
Fax
0550-5196001
Email
wj520wjxby@126.com
Country
China
ProdList
1944
Advantage
55
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View Lastest Price from JNJ 5207852 dihydrochloride manufacturers

Career Henan Chemical Co
Product
1-(4-(3-piperidin-1-ylpropoxy)benzyl)piperidine 398473-34-2
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2020-01-01

398473-34-2, JNJ 5207852 dihydrochlorideRelated Search:


  • JNJ 5207852 dihydrochloride
  • JNJ 5207852
  • Piperidine, 1-[3-[4-(1-piperidinylmethyl)phenoxy]propyl]-
  • 1-[3-[4-(1-Piperidinylmethyl)phenoxy]propyl]piperidine hydrochloride
  • 1-{3-[4-(PIPERIDIN-1-YLMETHYL)PHENOXY]PROPYL}PIPERIDINE
  • 1-(4-(3-piperidin-1-ylpropoxy)benzyl)piperidine
  • sleep,low,JNJ5207852,Histamine Receptor,JNJ-5207852,JNJ 5207852,Inhibitor,REM,toxicity,inhibit
  • JNJ-5207852, 10 mM in DMSO
  • 398473-34-2
  • 98473-34-2
  • C20H32N2O2HCl
  • Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals