JNJ 5207852 dihydrochloride
- Product Name
- JNJ 5207852 dihydrochloride
- CAS No.
- 398473-34-2
- Chemical Name
- JNJ 5207852 dihydrochloride
- Synonyms
- JNJ 5207852;JNJ-5207852, 10 mM in DMSO;JNJ 5207852 dihydrochloride;1-(4-(3-piperidin-1-ylpropoxy)benzyl)piperidine;1-{3-[4-(PIPERIDIN-1-YLMETHYL)PHENOXY]PROPYL}PIPERIDINE;Piperidine, 1-[3-[4-(1-piperidinylmethyl)phenoxy]propyl]-;1-[3-[4-(1-Piperidinylmethyl)phenoxy]propyl]piperidine hydrochloride;sleep,low,JNJ5207852,Histamine Receptor,JNJ-5207852,JNJ 5207852,Inhibitor,REM,toxicity,inhibit
- CBNumber
- CB82535676
- Molecular Formula
- C20H32N2O
- Formula Weight
- 316.48
- MOL File
- 398473-34-2.mol
JNJ 5207852 dihydrochloride Property
- Boiling point:
- 443.4±30.0 °C(Predicted)
- Density
- 1.032±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO : 77.5 mg/mL (244.88 mM; Need ultrasonic)
- form
- Powder
- pka
- 9.70±0.10(Predicted)
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 11998
- Product name
- JNJ-5207852
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $89
- Updated
- 2024/03/01
- Product number
- 11998
- Product name
- JNJ-5207852
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $168
- Updated
- 2024/03/01
- Product number
- 11998
- Product name
- JNJ-5207852
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $700
- Updated
- 2024/03/01
- Product number
- 4020
- Product name
- JNJ5207852dihydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $772
- Updated
- 2021/12/16
- Product number
- 4020
- Product name
- JNJ5207852dihydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $195
- Updated
- 2021/12/16
JNJ 5207852 dihydrochloride Chemical Properties,Usage,Production
Uses
JNJ 5207852 is a Histamine H3 Receptor antagonist, used in the treatment of obesity.
in vivo
JNJ-5207852 (1-10mg/kg s.c.) increases time spent awake and decreases REM sleep and slow-wave sleep, but fails to have an effect on wakefulness or sleep in H3 receptor knockout mice. The wake promoting effects of this H3 receptor antagonist are not associated with hypermotility. A 4-week daily treatment of mice with JNJ-5207852 (10 mg/kg i.p.) does not lead to a change in body weight. JNJ-5207852 is extensively absorbed after oral administration and reaches high brain levels[1].
| Animal Model: | Male, Sprague-Dawley rats weighing 282-334 g[1]. |
| Dosage: | 3, 10, 30 mg/kg. |
| Administration: | S.C. |
| Result: | Iincreased time spent awake and decreased REM sleep and slow-wave sleep. |
IC 50
H3 receptor: 8.9 (pKi, for rat); H3 receptor: 9.24 (pKi, for human)
JNJ 5207852 dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
JNJ 5207852 dihydrochloride Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77
View Lastest Price from JNJ 5207852 dihydrochloride manufacturers
- Product
- 1-(4-(3-piperidin-1-ylpropoxy)benzyl)piperidine 398473-34-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2020-01-01