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LY 266097 hydrochloride

Product Name
LY 266097 hydrochloride
CAS No.
172895-39-5
Chemical Name
LY 266097 hydrochloride
Synonyms
LY266097;LY 266097;LY 266097 hydrochloride;LY266097 >=98% (HPLC), powder;LY266097 hydrochloride, 10 mM in DMSO;LY-266097 hydrochloride,LY266097 hydrochloride;1-[(2-Chloro-3,4-dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride
CBNumber
CB82535681
Molecular Formula
C21H24Cl2N2O2
Formula Weight
407.34
MOL File
172895-39-5.mol
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LY 266097 hydrochloride Property

storage temp. 
2-8°C
solubility 
DMSO: ≥20mg/mL
form 
powder
color 
white to tan
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
L6670
Product name
LY266097
Purity
≥98% (HPLC), powder
Packaging
5mg
Price
$130.15
Updated
2025/07/31
Sigma-Aldrich
Product number
L6670
Product name
LY266097
Purity
≥98% (HPLC), powder
Packaging
25mg
Price
$548
Updated
2025/07/31
Cayman Chemical
Product number
11935
Product name
LY266097 (hydrochloride)
Packaging
500μg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
11935
Product name
LY266097 (hydrochloride)
Packaging
1mg
Price
$50
Updated
2024/03/01
Cayman Chemical
Product number
11935
Product name
LY266097 (hydrochloride)
Packaging
5mg
Price
$139
Updated
2024/03/01
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LY 266097 hydrochloride Chemical Properties,Usage,Production

Uses

LY 266097 Hydrochloride is a potent and selective serotonin 2B (5HT2B) contractile receptor.

Biological Activity

LY266097 is a selective 5HT-2B antagonist with a pKI of 9.7 for the human cloned 5-HT2B receptor and a 100-fold greater selectivity for 5-HT2B than the human 5-HT2C and 5-HT2A.

in vivo

LY266097 (0.6 mg/kg for 2-day administration) rescues Escitalopram-induced decrease in dopamine (DA) [1].
The administration of LY266097 alone or its addition on the last 3 days of a 14-day Escitalopram regimen increases pyramidal neuron firing and burst activity[1].

Animal Model:Male Sprague-Dawley rats weighing 250-350?g[1]
Dosage:0.6?mg/kg
Administration:Administered i.p. alone or concomitantly with Escitalopram (2?mg/kg) for 2 days
Result:Short-term administration (0.6?mg/kg/day for 2 days; i.p.) alone had no effect on these parameters, its co-administration counteracted the inhibitory effect of escitalopram on the firing activity of DA neurons, resulting in a recovery to control level.

IC 50

5-HT2B Receptor: 9.8 (pKi); 5-HT2A Receptor: 7.7 (pKi); 5-HT2C Receptor: 7.6 (pKi)

storage

Store at +4°C

LY 266097 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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LY 266097 hydrochloride Suppliers

China 21 United Kingdom 1 United States 7 Global 29
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77

172895-39-5, LY 266097 hydrochlorideRelated Search:


  • LY 266097 hydrochloride
  • 1-[(2-Chloro-3,4-dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride
  • LY 266097
  • LY266097
  • LY266097 >=98% (HPLC), powder
  • LY-266097 hydrochloride,LY266097 hydrochloride
  • LY266097 hydrochloride, 10 mM in DMSO
  • 172895-39-5
  • C21H23ClN2O2HCl