ChemicalBook > CAS DataBase List > 7-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo-, Methyl ester

7-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo-, Methyl ester

Product Name: 7-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo-, Methyl ester
CAS No.: 174074-88-5
Chemical Name: 7-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo-, Methyl ester
Synonyms: Methyl 2,4-dihydroxyquinazoline-7-carboxylate;methyl 2,4-dioxo-1H-quinazoline-7-carboxylate;1,2,3,4-tetrahydro-2,4-dioxo-7-Quinazolinecarboxylic acid methyl ester;7-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo-, Methyl ester
CBNumber: CB82547123
Molecular Formula: C10H8N2O4
Formula Weight: 220.18
MOL File: 174074-88-5.mol

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7-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo-, Methyl ester Property

Melting point:: 307-309 °C
Density: 1.382±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 9.82±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M343213
Product name: methyl2,4-dioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate
Packaging: 100mg
Price: $220
Updated: 2021/12/16

AK Scientific

Product number: Y6679
Product name: Methyl2,4-dihydroxyquinazoline-7-carboxylate
Packaging: 1g
Price: $423
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0077973
Product name: METHYL 2,4-DIHYDROXYQUINAZOLINE-7-CARBOXYLATE
Purity: 95.00%
Packaging: 1G
Price: $1015.25
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0077973
Product name: METHYL 2,4-DIHYDROXYQUINAZOLINE-7-CARBOXYLATE
Purity: 95.00%
Packaging: 5G
Price: $2425.5
Updated: 2021/12/16

Alichem

Product number: 174074885
Product name: Methyl2,4-dioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate
Packaging: 1g
Price: $520.74
Updated: 2021/12/16

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7-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo-, Methyl ester Chemical Properties,Usage,Production

Synthesis

60-35-5

5372-81-6

174074-88-5

Step 1: In a 250 mL round-bottom flask, dimethyl 2-aminoterephthalate (3 g, 0.0143 mol) and urea (4.3 g, 0.0717 mol) were added. The reaction mixture was stirred at 200 °C for 3 hours. Subsequently, the reaction mixture was cooled down to 100 °C and water was added. Stirring of the water-containing reaction mixture was continued at 100 °C for 5-10 min and then cooled to room temperature. The solid product was collected by filtration, washed with chloroform, dried and azeotroped with toluene to afford methyl 2,4-dioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate (2.5 g, 80% yield). The product can be used directly in the next reaction without further purification.1H NMR (400 MHz, DMSO-d6): δ 11.25 (br s, 2H), 7.98 (d, 1H, J = 8.2 Hz), 7.78 (s, 1H), 7.65 (d, J = 8.2, 1.2 Hz, 1H), 3.98 (s, 3H). LC-MS (ESI): calculated mass: 220.0; observed mass: 221.0 [M + H]+ (RT: 0.19 min).

References

[1] Patent: WO2012/58671, 2012, A1. Location in patent: Page/Page column 112-113

7-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo-, Methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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174074-88-5, 7-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo-, Methyl esterRelated Search:

7-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo-, Methyl ester

Methyl 2,4-dihydroxyquinazoline-7-carboxylate

1,2,3,4-tetrahydro-2,4-dioxo-7-Quinazolinecarboxylic acid methyl ester

methyl 2,4-dioxo-1H-quinazoline-7-carboxylate

174074-88-5