7-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo-, Methyl ester
- Product Name
- 7-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo-, Methyl ester
- CAS No.
- 174074-88-5
- Chemical Name
- 7-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo-, Methyl ester
- Synonyms
- Methyl 2,4-dihydroxyquinazoline-7-carboxylate;methyl 2,4-dioxo-1H-quinazoline-7-carboxylate;1,2,3,4-tetrahydro-2,4-dioxo-7-Quinazolinecarboxylic acid methyl ester;7-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo-, Methyl ester
- CBNumber
- CB82547123
- Molecular Formula
- C10H8N2O4
- Formula Weight
- 220.18
- MOL File
- 174074-88-5.mol
7-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo-, Methyl ester Property
- Melting point:
- 307-309 °C
- Density
- 1.382±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 9.82±0.20(Predicted)
N-Bromosuccinimide Price
- Product number
- M343213
- Product name
- methyl2,4-dioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate
- Packaging
- 100mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- Y6679
- Product name
- Methyl2,4-dihydroxyquinazoline-7-carboxylate
- Packaging
- 1g
- Price
- $423
- Updated
- 2021/12/16
- Product number
- CHM0077973
- Product name
- METHYL 2,4-DIHYDROXYQUINAZOLINE-7-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1015.25
- Updated
- 2021/12/16
- Product number
- CHM0077973
- Product name
- METHYL 2,4-DIHYDROXYQUINAZOLINE-7-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $2425.5
- Updated
- 2021/12/16
- Product number
- 174074885
- Product name
- Methyl2,4-dioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate
- Packaging
- 1g
- Price
- $520.74
- Updated
- 2021/12/16
7-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo-, Methyl ester Chemical Properties,Usage,Production
Synthesis
60-35-5
5372-81-6
174074-88-5
Step 1: In a 250 mL round-bottom flask, dimethyl 2-aminoterephthalate (3 g, 0.0143 mol) and urea (4.3 g, 0.0717 mol) were added. The reaction mixture was stirred at 200 °C for 3 hours. Subsequently, the reaction mixture was cooled down to 100 °C and water was added. Stirring of the water-containing reaction mixture was continued at 100 °C for 5-10 min and then cooled to room temperature. The solid product was collected by filtration, washed with chloroform, dried and azeotroped with toluene to afford methyl 2,4-dioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate (2.5 g, 80% yield). The product can be used directly in the next reaction without further purification.1H NMR (400 MHz, DMSO-d6): δ 11.25 (br s, 2H), 7.98 (d, 1H, J = 8.2 Hz), 7.78 (s, 1H), 7.65 (d, J = 8.2, 1.2 Hz, 1H), 3.98 (s, 3H). LC-MS (ESI): calculated mass: 220.0; observed mass: 221.0 [M + H]+ (RT: 0.19 min).
References
[1] Patent: WO2012/58671, 2012, A1. Location in patent: Page/Page column 112-113
7-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo-, Methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
7-Quinazolinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo-, Methyl ester Suppliers
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