ChemicalBook > CAS DataBase List > 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE

5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE

Product Name
5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE
CAS No.
218457-67-1
Chemical Name
5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE
Synonyms
Limantrafin;BUTTPARK 96\12-100;6-(4-tert-butylphenoxy)-3-pyridinamine;5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE;6-[4-(TERT-BUTYL)PHENOXY]PYRIDIN-3-AMINE;6-[4-(tert-Butyl)phenoxy]pyridin-3-amine97%;6-[4-(tert-Butyl)phenoxy]pyridin-3-amine 97%;6-[4-(1,1-Dimethylethyl)phenoxy]-3-pyridinamine;3-Pyridinamine, 6-[4-(1,1-dimethylethyl)phenoxy]-;pathway,CB103,inhibit,Inhibitor,Notch,CB-103,signaling,leukemia,CB 103
CBNumber
CB8254830
Molecular Formula
C15H18N2O
Formula Weight
242.32
MOL File
218457-67-1.mol
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5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE Property

Melting point:
89-90
storage temp. 
2-8°C
solubility 
Soluble in DMSO (>30 mg/ml)
form 
solid
color 
Off-white to pale orange
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
CAS DataBase Reference
218457-67-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Hazard Note 
Irritant
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3460
Product name
CB-103
Purity
≥97% (HPLC)
Packaging
10MG
Price
$64.8
Updated
2024/03/01
Sigma-Aldrich
Product number
SML3460
Product name
CB-103
Purity
≥97% (HPLC)
Packaging
50MG
Price
$261
Updated
2024/03/01
TRC
Product number
A594853
Product name
5-Amino-2-(4-tert-butylphenoxy)pyridine
Packaging
500mg
Price
$90
Updated
2021/12/16
TRC
Product number
A594853
Product name
5-Amino-2-(4-tert-butylphenoxy)pyridine
Packaging
100mg
Price
$60
Updated
2021/12/16
Apolloscientific
Product number
OR8051
Product name
6-[4-(tert-Butyl)phenoxy]pyridin-3-amine
Purity
97%
Packaging
1g
Price
$105
Updated
2021/12/16
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5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE Chemical Properties,Usage,Production

Description

CB-103 (218457-67-1) is an orally active inhibitor of the Notch signaling activation complex (IC50’s from 0.9 to 3.9 μM in various cell-based assays), the most downstream level of the Notch signaling pathway. It inhibited the growth of Notch-addicted human T cell acute lymphoblastic leukemia cells as well as other cell lines.? CB-103 also inhibited the growth of human breast cancer and leukemia xenografts without the intestinal toxicity associated with γ-secretase Notch inhibitors.

References

Lehal et al. (2020), Pharmacological disruption of the Notch transcription factor complex; Proc. Natl. Acad. Sci. USA, 117 16292

5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE Suppliers

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218457-67-1, 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINERelated Search:

PF-01367338 3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide METHOPRENE ACID Acalabrutinib 1-Bromo-4-tert-butylbenzene 4-t-Butylbenzamide 3-Amino-6-hydroxypyridine 2-methoxy-5-aminopyridine 6-PHENOXY-3-PYRIDINAMINE 2-PHENOXYPYRIDINE 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE

  • 6-[4-(tert-Butyl)phenoxy]pyridin-3-amine 97%
  • 6-[4-(tert-Butyl)phenoxy]pyridin-3-amine97%
  • 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE
  • 6-[4-(TERT-BUTYL)PHENOXY]PYRIDIN-3-AMINE
  • BUTTPARK 96\12-100
  • 6-(4-tert-butylphenoxy)-3-pyridinamine
  • 3-Pyridinamine, 6-[4-(1,1-dimethylethyl)phenoxy]-
  • pathway,CB103,inhibit,Inhibitor,Notch,CB-103,signaling,leukemia,CB 103
  • 6-[4-(1,1-Dimethylethyl)phenoxy]-3-pyridinamine
  • Limantrafin
  • 218457-67-1
  • C15H18N2O
  • ARYL AMINE