5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE
- Product Name
- 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE
- CAS No.
- 218457-67-1
- Chemical Name
- 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE
- Synonyms
- Limantrafin;BUTTPARK 96\12-100;6-(4-tert-butylphenoxy)-3-pyridinamine;5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE;6-[4-(TERT-BUTYL)PHENOXY]PYRIDIN-3-AMINE;6-[4-(tert-Butyl)phenoxy]pyridin-3-amine97%;6-[4-(tert-Butyl)phenoxy]pyridin-3-amine 97%;6-[4-(1,1-Dimethylethyl)phenoxy]-3-pyridinamine;3-Pyridinamine, 6-[4-(1,1-dimethylethyl)phenoxy]-;pathway,CB103,inhibit,Inhibitor,Notch,CB-103,signaling,leukemia,CB 103
- CBNumber
- CB8254830
- Molecular Formula
- C15H18N2O
- Formula Weight
- 242.32
- MOL File
- 218457-67-1.mol
5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE Property
- Melting point:
- 89-90
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO (>30 mg/ml)
- form
- solid
- color
- Off-white to pale orange
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
- CAS DataBase Reference
- 218457-67-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- SML3460
- Product name
- CB-103
- Purity
- ≥97% (HPLC)
- Packaging
- 10MG
- Price
- $64.8
- Updated
- 2024/03/01
- Product number
- SML3460
- Product name
- CB-103
- Purity
- ≥97% (HPLC)
- Packaging
- 50MG
- Price
- $261
- Updated
- 2024/03/01
- Product number
- A594853
- Product name
- 5-Amino-2-(4-tert-butylphenoxy)pyridine
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- A594853
- Product name
- 5-Amino-2-(4-tert-butylphenoxy)pyridine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- OR8051
- Product name
- 6-[4-(tert-Butyl)phenoxy]pyridin-3-amine
- Purity
- 97%
- Packaging
- 1g
- Price
- $105
- Updated
- 2021/12/16
5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE Chemical Properties,Usage,Production
Description
CB-103 (218457-67-1) is an orally active inhibitor of the Notch signaling activation complex (IC50’s from 0.9 to 3.9 μM in various cell-based assays), the most downstream level of the Notch signaling pathway. It inhibited the growth of Notch-addicted human T cell acute lymphoblastic leukemia cells as well as other cell lines.? CB-103 also inhibited the growth of human breast cancer and leukemia xenografts without the intestinal toxicity associated with γ-secretase Notch inhibitors.
References
Lehal et al. (2020), Pharmacological disruption of the Notch transcription factor complex; Proc. Natl. Acad. Sci. USA, 117 16292
5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE Suppliers
- Tel
- --
- Fax
- --
- y.barysheva@ukrorgsynth.com
- Country
- Ukraine
- ProdList
- 6230
- Advantage
- 38