ChemicalBook > CAS DataBase List > 2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate

2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate

Product Name
2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate
CAS No.
1041026-71-4
Chemical Name
2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate
Synonyms
tert-butyl 2,6-diazaspiro[3.3]heptane-2-carboxylate oxalate;tert-Butyl 2,6-diazaspiro[3.3]heptane-2-carboxylate oxalate(2:1);2-Boc-2,6-diazaspiro[3.3]heptane Hemioxalate;6-diazaspiro[3.3]heptane-2-carboxylate oxalate;1-Boc-2,6-diazaspiro[3.3]heptanehemioxalate,97%;1-Boc-2,6-diazaspiro[3.3]heptane heMioxalate, 97%;2-Boc-2,6-Diazaspiro[3.3]heptane ethanedioate (2:1);2,6-Diazaspiro[3.3]heptane, N2-BOC protected hemioxalate;ert-Butyl 2,6-diazaspiro[3,3]heptane-2-carboxylate hemioxalate;tert-Butyl 2,6-diazaspiro[3,3]heptane-2-carboxylate hemioxalate
CBNumber
CB82548539
Molecular Formula
C22H38N4O8
Formula Weight
486.56
MOL File
1041026-71-4.mol
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2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate Property

Melting point:
206-209℃
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO (Slightly, Heated), Methanol (Slightly, Sonicated)
form 
Solid
color 
White to Off-White
Water Solubility 
Slightly soluble in water.
Stability:
Hygroscopic
InChI
InChI=1S/2C10H18N2O2.C2H2O4/c2*1-9(2,3)14-8(13)12-6-10(7-12)4-11-5-10;3-1(4)2(5)6/h2*11H,4-7H2,1-3H3;(H,3,4)(H,5,6)
InChIKey
PYRAMVPOMDHTNX-UHFFFAOYSA-N
SMILES
C12(CN(C(=O)OC(C)(C)C)C1)CNC2.C(C(O)=O)(O)=O.C12(CN(C(=O)OC(C)(C)C)C1)CNC2
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P321Specific treatment (see … on this label).

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N-Bromosuccinimide Price

TRC
Product number
D417620
Product name
2,6-Diazaspiro[3.3]heptane-2-carboxylicAcidtert-ButylEsterHemioxalate
Packaging
100mg
Price
$70
Updated
2021/12/16
Synthonix
Product number
D6051
Product name
2,6-Diazaspiro[3.3]heptane-2-carboxylicacidtert-butylesterhemioxalate
Purity
97.0%
Packaging
1g
Price
$30
Updated
2021/12/16
Apolloscientific
Product number
OR312002
Product name
2,6-Diazaspiro[3.3]heptane,N2-BOCprotectedhemioxalate
Purity
97%
Packaging
1g
Price
$58
Updated
2021/12/16
SynQuest Laboratories
Product number
4H22-1-27
Product name
2,6-Diazaspiro[3.3]heptane-2-carboxylic acid ethanedioate, 1,1-dimethylethyl ester
Packaging
1g
Price
$64
Updated
2021/12/16
Synthonix
Product number
D6051
Product name
2,6-Diazaspiro[3.3]heptane-2-carboxylicacidtert-butylesterhemioxalate
Purity
97.0%
Packaging
5g
Price
$120
Updated
2021/12/16
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2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate Chemical Properties,Usage,Production

Chemical Properties

white to yellow Solid.

Uses

It is employed as a intermediate for pharmaceutical.

Uses

2,6-Diazaspiro[3.3]heptane-2-carboxylic Acid tert-Butyl Ester Hemioxylate is preparation of pyrimidine derivatives and related heterocycles as CDK inhibitors for treatment of diseases.

Preparation

Synthesis of 2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate: Take a 500mL single-necked bottle, add 6-toluenesulfonyl-2,6-diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester (7g, 20mmol), dissolve in methanol (200mL), add magnesium chips (3.84 g) g, 0.16 mol, 8 equiv) and stirred at room temperature. The reaction solution gradually turned into a white viscous state with the dissolution of the magnesium scraps, and TLC showed that the reaction of the raw materials was completed. The solvent was removed by rotary evaporation, ether (150 mL) was added, stirred at room temperature for 1 h, filtered through celite, the filtrate was dried over anhydrous sodium sulfate, and an ethanol solution (3 mL) of anhydrous oxalic acid (0.89 g, 9.9 mmol, 0.5 equiv) was added dropwise, A white precipitate appeared immediately, which was filtered under reduced pressure to give 3.2 g of a colorless solid, 82%.

2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate Suppliers

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View Lastest Price from 2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
tert-butyl 2,6-diazaspiro[3.3]heptane-2-carboxylate oxalate 1041026-71-4
Price
US $0.00/KG
Min. Order
1KG
Purity
97%min
Supply Ability
10KG
Release date
2021-10-21
Career Henan Chemical Co
Product
tert-butyl 2,6-diazaspiro[3.3]heptane-2-carboxylate oxalate 1041026-71-4
Price
US $1.00/KG
Min. Order
1KG
Purity
95%
Supply Ability
500KG
Release date
2018-08-19

1041026-71-4, 2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylateRelated Search:

tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate tert-butyl 2,6-diazaspiro[3.3]heptane-2-carboxylate hydrochloride tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate 2,3,3a,8a-Tetrahydro-1H-2-aza-cyclopenta[a]inden-8-one 1-Oxa-4,8-diazaspiro[5.5]undecan-8-carboxylic acid tert-butyl ester 3-Azabicyclo[3.1.0]hexane-3,6-dicarboxylic acid 3-tert-butyl ester 7-Boc-1,7-diaza-spiro[4.4]nonane Tert-butyl 2,6-diazaspiro[3.4]octane-6-carboxylate 1-BENZYL-OCTAHYDRO-PYRROLO[3,4-B]PYRROLE 2-(3-(TERT-BUTOXYCARBONYL)-3-AZASPIRO[5.5]UNDECAN-9-YL)ACETIC ACID Carbamic acid, 3-azabicyclo[3.1.0]hex-1-yl-, 1,1-dimethylethyl ester (9CI) 4-OXO-HEXAHYDRO-CYCLOPENTA[C]PYRROLE-2-CARBOXYLIC ACID TERT-BUTYL ESTER TERT-BUTYL 1-OXO-2,7-DIAZASPIRO[4.5]DECANE-7-CARBOXYLATE BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER Tert-butyl 1,7-diazaspiro[4,4]nonane-1-carboxylate Tert-butyl 2,6-diazaspiro[3.4]octane-2-carboxylate benzyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate 2S-7-Aza-bicyclo[2.2.1]heptane-2,7-dicarboxylic acid 7-tert-butyl ester

  • 2,6-Diazaspiro[3.3]heptane, N2-BOC protected hemioxalate
  • 2,6-Diazaspiro[3.3]heptane-2-carboxylic acid ethanedioate, 1,1-dimethylethyl ester
  • tert-butyl 2,6-diazaspiro[3.3]heptane-2-carboxylate oxalate
  • 2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester heMioxylate
  • 2,6-Diazaspiro[3.3]heptane-2-carboxylic acid, 1,1-diMethylethyl ester, ethanedioate (2:1)
  • 1-Boc-2,6-diazaspiro[3.3]heptane heMioxalate, 97%
  • tert-Butyl 2,6-diazaspiro[3.3]heptane-2-carboxylate, hemioxalate salt
  • 2,6-Diazaspiro[3.3]heptane-2-carboxylic acid, 1,1-diMethylethyl ester, heMioxalate
  • tert-Butyl 2,6-diazaspiro[3.3]heptane-2-carboxylate oxalate(2:1)
  • 2,6-Diazaspiro[3.3]heptane-2-carboxylic acid 1,1-dimethylethyl ester ethanedioate
  • tert-Butyl 2,6-diazaspiro[3,3]heptane-2-carboxylate hemioxalate
  • 2,6-diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester oxalate
  • 2,6-diaza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester, oxalic acid salt
  • 2-Boc-2,6-diazaspiro[3.3]heptane Hemioxalate
  • 2-Methyl-2-propanyl 2,6-diazaspiro[3.3]heptane-2-carboxylate ethanedioate
  • 2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxalate
  • 2-Methyl-2-propanyl 2,6-diazaspiro[3.3]heptane-2-carboxylate ethanedioate (2:1)
  • 1-Boc-2,6-diazaspiro[3.3]heptanehemioxalate,97%
  • 2,6-diazo-heterospiro [3,3] heptane-2-carboxylic acid tert-butyl semicarbamate
  • 6-diazaspiro[3.3]heptane-2-carboxylate oxalate
  • 3-Oxazolidinecarboxylicacid,2,2-dimethyl-4-(2-oxoethyl)-,1,1-dimethylethylester,(10S)-
  • 2-Boc-2,6-Diazaspiro[3.3]heptane ethanedioate (2:1)
  • ert-Butyl 2,6-diazaspiro[3,3]heptane-2-carboxylate hemioxalate
  • tert-Butyl 2,6-diazaspiro[3.3]heptane-2-carboxylate semioxalate
  • 2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate/TERT-BUTYL 2,6-DIAZASPIRO[3.3]HEPTANE-2-CARBOXYLATE
  • tert-Butyl 2,6-diazaspiro[3.3]heptane-2-carboxylate hemioxylate
  • 2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxalate - [D6051]
  • tert-butyl 2,6-diazaspiro[3.3]heptane-3-carboxylate hemioxalate
  • 2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester, oxalate (2:1)
  • 1041026-71-4
  • 1041026-71-5
  • 2C10H18N2O2C2H2O4