Dibenzyl chloroMethyl phosphate
- Product Name
- Dibenzyl chloroMethyl phosphate
- CAS No.
- 258516-84-6
- Chemical Name
- Dibenzyl chloroMethyl phosphate
- Synonyms
- DIBENZYL CHLOROMETHYL PHOSPHATE;5-amino-6-fluoropyridine-5-carbonitrile;Chloromethyl bis(phenylmethyl) phosphate;Phosphoric acid, chloromethyl bis(phenylmethyl) ester
- CBNumber
- CB82550677
- Molecular Formula
- C15H16ClO4P
- Formula Weight
- 326.71
- MOL File
- 258516-84-6.mol
Dibenzyl chloroMethyl phosphate Property
- Boiling point:
- 433.2±45.0 °C(Predicted)
- Density
- 1.285±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- form
- liquid
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P314Get medical advice/attention if you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 86546
- Product name
- Dibenzyl chloromethyl phosphate
- Purity
- for HPLC derivatisation, ≥97.0%, ≥97.0% (HPLC)
- Packaging
- 1g
- Price
- $694
- Updated
- 2024/03/01
- Product number
- D422695
- Product name
- Dibenzyl chloromethyl phosphate
- Packaging
- 2.5g
- Price
- $180
- Updated
- 2021/12/16
- Product number
- 243773
- Product name
- Dibenzyl (chloromethyl) phosphate
- Packaging
- 250mg
- Price
- $25
- Updated
- 2021/12/16
- Product number
- FD137347
- Product name
- Dibenzyl chloromethyl phosphate
- Packaging
- 250mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 243773
- Product name
- Dibenzyl (chloromethyl) phosphate
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
Dibenzyl chloroMethyl phosphate Chemical Properties,Usage,Production
Uses
Dibenzyl (Chloromethyl) Phosphate acts as a reagent in the screening and synthesis of potent NPP6 inhibitor.
Uses
Synthesis of water-soluble prodrugs of lipophilic alcohols, phenols and amines. Dibenzyl chloromethyl phosphate is an improved derivative of the well known Di-tert-butyl chloromethyl phosphate. So it can be detected more easily by HPLC-UV, because of higher stability, higher yields and better UV-activity.
reaction suitability
reagent type: derivatization reagent
reaction type: Acylations
Synthesis
3518-65-8
1623-08-1
258516-84-6
Step 1: Synthesis of dibenzyl chloromethyl phosphate (33B) Dibenzyl chloromethyl phosphate (33A) (5.0 g, 0.018 mol) was dissolved in a solvent mixture of dichloromethane (50 mL) and water (50 mL), followed by the addition of tetrabutylammonium sulfate (1.22 g, 0.0036 mol) as a phase transfer catalyst. Sodium bicarbonate (6.0 g, 0.072 mol) was slowly added to adjust the pH of the reaction system under cooling conditions in an ice-water bath. Next, chloromethanesulfonyl chloride (2.97 g, 1.9 mL) was added dropwise to the reaction mixture. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the reaction was allowed to partition, the organic phase was separated, and the aqueous phase was extracted with dichloromethane (50 mL). The organic extracts were combined and washed with saturated sodium chloride solution (100 mL x 2) to remove residual water-soluble impurities. The organic layers were dried over anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography using a gradient elution of petroleum ether/ethyl acetate (v/v = 5:1→3:1) to afford dibenzyl chloromethyl phosphate (33B) as a colorless liquid (4.35 g, yield: 74.1%). 1H NMR (400 MHz, CDCl3): δ 7.36-7.26 (m, 10H), 5.63 (d, 2H), 5.10 (d, 4H).
References
[1] Patent: US2016/60197, 2016, A1. Location in patent: Paragraph 0362; 0363; 0364; 0365
[2] Patent: KR2016/5361, 2016, A. Location in patent: Paragraph 1019; 1022; 1023-1025
[3] Journal of the American Chemical Society, 2011, vol. 133, # 31, p. 12021 - 12030
Dibenzyl chloroMethyl phosphate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Dibenzyl chloroMethyl phosphate manufacturers
- Product
- Dibenzyl chloroMethyl phosphate 258516-84-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 85.0-99.8%
- Supply Ability
- 20 tons
- Release date
- 2019-12-24