2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride

Product Name: 2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride
CAS No.: 406209-26-5
Chemical Name: 2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride
Synonyms: IKK-beta inhibitor;IKK-2 inhibitor VIII;1IKK-2 Inhibitor VIII;ACHP (Hydrochloride );Bayer IKK-beta inhibitor;ACHP Hydrochloride, 10 mM in DMSO;2-amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-;I kappa B kinase,IκB kinase,Inhibitor,ACHP,inhibit,IKK,ACHP Hydrochloride;2-amino-6-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-4-(piperidin-4-yl)nicotinonitrile hydrochloride;2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride
CBNumber: CB82554327
Molecular Formula: C21H25ClN4O2
Formula Weight: 400.91
MOL File: 406209-26-5.mol

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2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride Property

storage temp.: Store at -20°C
solubility: DMSO : 50 mg/mL (124.72 mM; Need ultrasonic)
form: Powder
color: Off-white to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0283
Product name: ACHPHydrochloride
Purity: 99.54%
Packaging: 5mg
Price: $221
Updated: 2021/12/16

ChemScene

Product number: CS-0283
Product name: ACHPHydrochloride
Purity: 99.54%
Packaging: 10mg
Price: $356
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0001487
Product name: IKK-2 INHIBITOR VIII
Purity: 95.00%
Packaging: 5MG
Price: $520
Updated: 2021/12/16

ChemScene

Product number: CS-0283
Product name: ACHPHydrochloride
Purity: 99.54%
Packaging: 50mg
Price: $838
Updated: 2021/12/16

ChemScene

Product number: CS-0283
Product name: ACHPHydrochloride
Purity: 99.54%
Packaging: 100mg
Price: $1307
Updated: 2021/12/16

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2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride Chemical Properties,Usage,Production

Uses

ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM.

in vivo

ACHP (Compound 4j) is orally bioavailable in mice and rats and demonstrates significant in vivo activity in anti-inflammatory models (arachidonic acid-induced mouse ear edema model). ACHP has reasonable aqueous solubility (0.12 mg/mL in pH 7.4 isotonic buffer) and excellent Caco-2 permeability (P_app 62.3×10^-7 cm/s), and demonstrates orally bioavailability in mice (BA: 16%) and rats (BA: 60%). The favourable bioavailability of ACHP in rats is likely due to its low clearance (0.33 L/h/kg). In an acute inflammation model, ACHP exhibits oral efficacy at 1 mg/kg in a dose-dependent manner^[1].

IC 50

IKK-β: 8.5 nM (IC₅₀); IKK-α: 250 nM (IC₅₀)

References

[1] Murata T, et al. Synthesis and structure-activity relationships of novel IKK-beta inhibitors. Part 3: Orally active anti-inflammatory agents. Bioorg Med Chem Lett. 2004 Aug 2;14(15):4019-22. DOI:10.1016/j.bmcl.2004.05.041
[2] Sanda T, et al. Induction of cell death in adult T-cell leukemia cells by a novel IkappaB kinase inhibitor. Leukemia. 2006 Apr;20(4):590-8. DOI:10.1038/sj.leu.2404129

2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride Suppliers

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406209-26-5, 2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochlorideRelated Search:

2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride

Bayer IKK-beta inhibitor

IKK-2 inhibitor VIII

IKK-beta inhibitor

3-Pyridinecarbonitrile, 2-aMino-6-[2-(cyclopropylMethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-, hydrochloride (1:1)

ACHP (Hydrochloride )

2-amino-6-[2-(cyclopropylmethoxy)-6-oxocyclohexa-2,4-dien-1-ylidene]-4-piperidin-4-yl-1H-pyridine-3-carbonitrile

(6Z)-2-amino-6-[2-(cyclopropylmethoxy)-6-oxocyclohexa-2,4-dien-1-ylidene]-4-piperidin-4-yl-1H-pyridine-3-carbonitrile

(6E)-2-amino-6-[2-(cyclopropylmethoxy)-6-oxocyclohexa-2,4-dien-1-ylidene]-4-piperidin-4-yl-1H-pyridine-3-carbonitrile

2-amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-

IKK-BETA INHIBITOR;3-PYRIDINECARBONITRILE; 2-AMINO-6-[2-(CYCLOPROPYLMETHOXY)-6-HYDROXYPHENYL]-4-(4-PIPERIDINYL)-; HYDROCHLORIDE (1:1)

I kappa B kinase,IκB kinase,Inhibitor,ACHP,inhibit,IKK,ACHP Hydrochloride

2-amino-6-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-4-(piperidin-4-yl)nicotinonitrile hydrochloride

ACHP Hydrochloride, 10 mM in DMSO

1IKK-2 Inhibitor VIII

406209-26-5

C21H24N4O2HCl