ChemicalBook > CAS DataBase List > 2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride

2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride

Product Name
2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride
CAS No.
406209-26-5
Chemical Name
2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride
Synonyms
IKK-beta inhibitor;IKK-2 inhibitor VIII;1IKK-2 Inhibitor VIII;ACHP (Hydrochloride );Bayer IKK-beta inhibitor;ACHP Hydrochloride, 10 mM in DMSO;2-amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-;I kappa B kinase,IκB kinase,Inhibitor,ACHP,inhibit,IKK,ACHP Hydrochloride;2-amino-6-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-4-(piperidin-4-yl)nicotinonitrile hydrochloride;2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride
CBNumber
CB82554327
Molecular Formula
C21H25ClN4O2
Formula Weight
400.91
MOL File
406209-26-5.mol
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2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride Property

storage temp. 
Store at -20°C
solubility 
DMSO : 50 mg/mL (124.72 mM; Need ultrasonic)
form 
Powder
color 
Off-white to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0283
Product name
ACHPHydrochloride
Purity
99.54%
Packaging
5mg
Price
$221
Updated
2021/12/16
ChemScene
Product number
CS-0283
Product name
ACHPHydrochloride
Purity
99.54%
Packaging
10mg
Price
$356
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0001487
Product name
IKK-2 INHIBITOR VIII
Purity
95.00%
Packaging
5MG
Price
$520
Updated
2021/12/16
ChemScene
Product number
CS-0283
Product name
ACHPHydrochloride
Purity
99.54%
Packaging
50mg
Price
$838
Updated
2021/12/16
ChemScene
Product number
CS-0283
Product name
ACHPHydrochloride
Purity
99.54%
Packaging
100mg
Price
$1307
Updated
2021/12/16
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2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride Chemical Properties,Usage,Production

Uses

ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM.

in vivo

ACHP (Compound 4j) is orally bioavailable in mice and rats and demonstrates significant in vivo activity in anti-inflammatory models (arachidonic acid-induced mouse ear edema model). ACHP has reasonable aqueous solubility (0.12 mg/mL in pH 7.4 isotonic buffer) and excellent Caco-2 permeability (Papp 62.3×10-7 cm/s), and demonstrates orally bioavailability in mice (BA: 16%) and rats (BA: 60%). The favourable bioavailability of ACHP in rats is likely due to its low clearance (0.33 L/h/kg). In an acute inflammation model, ACHP exhibits oral efficacy at 1 mg/kg in a dose-dependent manner[1].

IC 50

IKK-β: 8.5 nM (IC50); IKK-α: 250 nM (IC50)

References

[1] Murata T, et al. Synthesis and structure-activity relationships of novel IKK-beta inhibitors. Part 3: Orally active anti-inflammatory agents. Bioorg Med Chem Lett. 2004 Aug 2;14(15):4019-22. DOI:10.1016/j.bmcl.2004.05.041
[2] Sanda T, et al. Induction of cell death in adult T-cell leukemia cells by a novel IkappaB kinase inhibitor. Leukemia. 2006 Apr;20(4):590-8. DOI:10.1038/sj.leu.2404129

2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride Suppliers

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406209-26-5, 2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochlorideRelated Search:


  • 2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride
  • Bayer IKK-beta inhibitor
  • IKK-2 inhibitor VIII
  • IKK-beta inhibitor
  • 3-Pyridinecarbonitrile, 2-aMino-6-[2-(cyclopropylMethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-, hydrochloride (1:1)
  • ACHP (Hydrochloride )
  • 2-amino-6-[2-(cyclopropylmethoxy)-6-oxocyclohexa-2,4-dien-1-ylidene]-4-piperidin-4-yl-1H-pyridine-3-carbonitrile
  • (6Z)-2-amino-6-[2-(cyclopropylmethoxy)-6-oxocyclohexa-2,4-dien-1-ylidene]-4-piperidin-4-yl-1H-pyridine-3-carbonitrile
  • (6E)-2-amino-6-[2-(cyclopropylmethoxy)-6-oxocyclohexa-2,4-dien-1-ylidene]-4-piperidin-4-yl-1H-pyridine-3-carbonitrile
  • 2-amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-
  • IKK-BETA INHIBITOR;3-PYRIDINECARBONITRILE; 2-AMINO-6-[2-(CYCLOPROPYLMETHOXY)-6-HYDROXYPHENYL]-4-(4-PIPERIDINYL)-; HYDROCHLORIDE (1:1)
  • I kappa B kinase,IκB kinase,Inhibitor,ACHP,inhibit,IKK,ACHP Hydrochloride
  • 2-amino-6-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-4-(piperidin-4-yl)nicotinonitrile hydrochloride
  • ACHP Hydrochloride, 10 mM in DMSO
  • 1IKK-2 Inhibitor VIII
  • 406209-26-5
  • C21H24N4O2HCl