2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride

Product Name: 2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride
CAS No.: 406209-26-5
Chemical Name: 2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride
Synonyms: IKK-beta inhibitor;IKK-2 inhibitor VIII;1IKK-2 Inhibitor VIII;ACHP (Hydrochloride );Bayer IKK-beta inhibitor;ACHP Hydrochloride, 10 mM in DMSO;2-amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-;I kappa B kinase,IκB kinase,Inhibitor,ACHP,inhibit,IKK,ACHP Hydrochloride;2-amino-6-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-4-(piperidin-4-yl)nicotinonitrile hydrochloride;2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride
CBNumber: CB82554327
Molecular Formula: C21H25ClN4O2
Formula Weight: 400.91
MOL File: 406209-26-5.mol

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2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride Property

storage temp.: Store at -20°C
solubility: DMSO : 50 mg/mL (124.72 mM; Need ultrasonic)
form: Powder
color: Off-white to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0283
Product name: ACHPHydrochloride
Purity: 99.54%
Packaging: 5mg
Price: $221
Updated: 2021/12/16

ChemScene

Product number: CS-0283
Product name: ACHPHydrochloride
Purity: 99.54%
Packaging: 10mg
Price: $356
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0001487
Product name: IKK-2 INHIBITOR VIII
Purity: 95.00%
Packaging: 5MG
Price: $520
Updated: 2021/12/16

ChemScene

Product number: CS-0283
Product name: ACHPHydrochloride
Purity: 99.54%
Packaging: 50mg
Price: $838
Updated: 2021/12/16

ChemScene

Product number: CS-0283
Product name: ACHPHydrochloride
Purity: 99.54%
Packaging: 100mg
Price: $1307
Updated: 2021/12/16

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2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride Chemical Properties,Usage,Production

Uses

ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM.

in vivo

ACHP (Compound 4j) is orally bioavailable in mice and rats and demonstrates significant in vivo activity in anti-inflammatory models (arachidonic acid-induced mouse ear edema model). ACHP has reasonable aqueous solubility (0.12 mg/mL in pH 7.4 isotonic buffer) and excellent Caco-2 permeability (P_app 62.3×10^-7 cm/s), and demonstrates orally bioavailability in mice (BA: 16%) and rats (BA: 60%). The favourable bioavailability of ACHP in rats is likely due to its low clearance (0.33 L/h/kg). In an acute inflammation model, ACHP exhibits oral efficacy at 1 mg/kg in a dose-dependent manner^[1].

IC 50

IKK-β: 8.5 nM (IC₅₀); IKK-α: 250 nM (IC₅₀)

References

[1] Murata T, et al. Synthesis and structure-activity relationships of novel IKK-beta inhibitors. Part 3: Orally active anti-inflammatory agents. Bioorg Med Chem Lett. 2004 Aug 2;14(15):4019-22. DOI:10.1016/j.bmcl.2004.05.041
[2] Sanda T, et al. Induction of cell death in adult T-cell leukemia cells by a novel IkappaB kinase inhibitor. Leukemia. 2006 Apr;20(4):590-8. DOI:10.1038/sj.leu.2404129

2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride Suppliers

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406209-26-5, 2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochlorideRelated Search:

2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride

Bayer IKK-beta inhibitor

IKK-2 inhibitor VIII

IKK-beta inhibitor

3-Pyridinecarbonitrile, 2-aMino-6-[2-(cyclopropylMethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-, hydrochloride (1:1)

ACHP (Hydrochloride )

2-amino-6-[2-(cyclopropylmethoxy)-6-oxocyclohexa-2,4-dien-1-ylidene]-4-piperidin-4-yl-1H-pyridine-3-carbonitrile

(6Z)-2-amino-6-[2-(cyclopropylmethoxy)-6-oxocyclohexa-2,4-dien-1-ylidene]-4-piperidin-4-yl-1H-pyridine-3-carbonitrile

(6E)-2-amino-6-[2-(cyclopropylmethoxy)-6-oxocyclohexa-2,4-dien-1-ylidene]-4-piperidin-4-yl-1H-pyridine-3-carbonitrile

2-amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-

IKK-BETA INHIBITOR;3-PYRIDINECARBONITRILE; 2-AMINO-6-[2-(CYCLOPROPYLMETHOXY)-6-HYDROXYPHENYL]-4-(4-PIPERIDINYL)-; HYDROCHLORIDE (1:1)

I kappa B kinase,IκB kinase,Inhibitor,ACHP,inhibit,IKK,ACHP Hydrochloride

2-amino-6-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-4-(piperidin-4-yl)nicotinonitrile hydrochloride

ACHP Hydrochloride, 10 mM in DMSO

1IKK-2 Inhibitor VIII

406209-26-5

C21H24N4O2HCl