tert-butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate

Product Name: tert-butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate
CAS No.: 1215071-17-2
Chemical Name: tert-butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate
Synonyms: tert-Butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate hydrate;EOS-61163;N-Boc-3,3-difluoropiperidin-4-one;N-t-BOC-5,5-Difluoro-4-Piperidinone;1-Boc-3,3-difluoro-4-oxo-piperidine;N1-BOC-3,3-Difluoro-4-oxo-piperidine;3,3-difluoro-4-oxopiperidine-1- carboxylate;tert-Butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate;tert-Butyl 3,3-difluoro-4-oxo-piperidin-1-carboxylate;1-(tert-Butyloxycarbonyl)-3,3-difluoro-4-oxopiperidine
CBNumber: CB82558613
Molecular Formula: C10H15F2NO3
Formula Weight: 235.23
MOL File: 1215071-17-2.mol

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tert-butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate Property

Boiling point:: 274.7±40.0 °C(Predicted)
Density: 1.21±0.1 g/cm3(Predicted)
storage temp.: 2-8°C, stored under nitrogen
pka: -5?+-.0.40(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C10H15F2NO3/c1-9(2,3)16-8(15)13-5-4-7(14)10(11,12)6-13/h4-6H2,1-3H3
InChIKey: GDZBFUOJMJSIAZ-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(=O)C(F)(F)C1

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B789415
Product name: tert-Butyl3,3-Difluoro-4-oxopiperidine-1-carboxylate
Packaging: 100mg
Price: $65
Updated: 2021/12/16

Matrix Scientific

Product number: 070445
Product name: tert-Butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate hydrate
Purity: 97+%
Packaging: 500mg
Price: $98
Updated: 2021/12/16

AK Scientific

Product number: Y7254
Product name: tert-Butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate hydrate
Packaging: 250mg
Price: $100
Updated: 2021/12/16

Matrix Scientific

Product number: 070445
Product name: tert-Butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate hydrate
Purity: 97+%
Packaging: 1g
Price: $148
Updated: 2021/12/16

Matrix Scientific

Product number: 070445
Product name: tert-Butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate hydrate
Purity: 97+%
Packaging: 5g
Price: $445
Updated: 2021/12/16

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tert-butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate Chemical Properties,Usage,Production

Synthesis

24424-99-5

1039741-54-2

1215071-17-2

Di-tert-butyl dicarbonate (1.19 g, 5.44 mmol) was slowly added to a solution of 1-benzyl-3,3-difluoropiperidin-4-one (995 mg, 4.42 mmol) dissolved in anhydrous ethanol (60 mL) under nitrogen protection. Subsequently, 20% palladium hydroxide/carbon catalyst (148 mg, 1.05 mmol) was added, and the reaction system was evacuated and displaced three times with hydrogen. The reaction mixture was stirred at room temperature and under hydrogen atmosphere for 20 hours. After completion of the reaction, residual hydrogen was removed and the reaction mixture was filtered through diatomaceous earth (Celite) and the filter cake was washed well with anhydrous ethanol. After purification, the target product tert-butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate (810 mg, 3.44 mmol, 78% yield) was obtained as a white solid.1H NMR (400 MHz, DMSO-d6): δ 3.66-3.52 (m, 2H), 3.39-3.33 (m, 2H), 1.69-1.64 (m, 2H) , 1.38 (s, 9H).

References

[1] Patent: WO2017/103611, 2017, A1. Location in patent: Paragraph 00447

tert-butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate Suppliers

Canada 1 China 86 India 1 Switzerland 1 United States 6 Global 95

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View Lastest Price from tert-butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: tert-butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate 1215071-17-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-26

Zhuozhou Wenxi import and Export Co., Ltd

Product: tert-butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate 1215071-17-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

1215071-17-2, tert-butyl 3,3-difluoro-4-oxopiperidine-1-carboxylateRelated Search:

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tert-Butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate hydrate

tert-Butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate

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1-Boc-3,3-difluoro-4-oxo-piperidine

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N-t-BOC-5,5-Difluoro-4-Piperidinone

EOS-61163

3,3-difluoro-4-oxopiperidine-1- carboxylate

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N1-BOC-3,3-Difluoro-4-oxo-piperidine

3,3-Difluoro-4-oxo-piperidine-1-carboxylic acid tert-butyl ester hydrate

tert-Butyl 3,3-difluoro-4-oxo-piperidin-1-carboxylate

1215071-17-2

1400164-85-8

C10H15F2NO3