3,4-DIHYDRO-2H-QUINOXALINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Product Name
- 3,4-DIHYDRO-2H-QUINOXALINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CAS No.
- 887590-25-2
- Chemical Name
- 3,4-DIHYDRO-2H-QUINOXALINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Synonyms
- tert-butyl 3,4-dihydro-2H-quinoxaline-1-carboxylate;1-Boc-1,2,3,4-tetrahydroquinoxaline;tert-butyl 3,4-dihydroquinoxaline-1(2H)-carboxylat;ert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate;tert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate;TERT-BUTYL1,2,3,4-TETRAHYDROQUINOXALINE-1-CARBOXYLATE;3,4-DIHYDRO-2H-QUINOXALINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1(2H)-Quinoxalinecarboxylic acid, 3,4-dihydro-, 1,1-dimethylethyl ester
- CBNumber
- CB4354987
- Molecular Formula
- C13H18N2O2
- Formula Weight
- 234.29
- MOL File
- 887590-25-2.mol
3,4-DIHYDRO-2H-QUINOXALINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Property
- Boiling point:
- 345.3±22.0 °C(Predicted)
- Density
- 1.112±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 3.27±0.70(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- FB139572
- Product name
- tert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate
- Packaging
- 250mg
- Price
- $62.5
- Updated
- 2021/12/16
- Product number
- 4607AC
- Product name
- tert-Butyl3,4-dihydroquinoxaline-1(2H)-carboxylate
- Packaging
- 1g
- Price
- $299
- Updated
- 2021/12/16
- Product number
- FB139572
- Product name
- tert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate
- Packaging
- 2g
- Price
- $324
- Updated
- 2021/12/16
- Product number
- CHM0394015
- Product name
- TERT-BUTYL-3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.78
- Updated
- 2021/12/16
- Product number
- 089744
- Product name
- tert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $742
- Updated
- 2021/12/16
3,4-DIHYDRO-2H-QUINOXALINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production
Synthesis
3476-89-9
24424-99-5
887590-25-2
GENERAL STEPS: Lithium aluminum hydride (LiAlH4, 228 mg, 6 mmol) was added batchwise to a stirred tetrahydrofuran (THF, 10 mL) solution of 1,2,3,4-tetrahydroquinoxaline (270 mg, 2 mmol) at 0 °C. The reaction mixture was stirred at 0 °C for 30 min, then brought to room temperature and stirred overnight. Upon completion of the reaction, the reaction was quenched sequentially by the addition of 0.25 mL of water, 0.25 mL of 5N sodium hydroxide solution and 1.25 mL of water. The insoluble material was removed by filtration and the filtrate was extracted with ethyl acetate (EtOAc, 3 x 20 mL). The organic layers were combined, washed with saturated saline, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The crude product was purified by fast column chromatography (eluent: 0-60% ethyl acetate/hexane) to give a light yellow solid (90 mg, 34% yield). The product obtained in the previous step (90 mg, 0.67 mmol) was dissolved in THF at 0 °C and di-tert-butyl dicarbonate (Boc2O, 146 mg, 0.67 mmol) and 1N aqueous sodium hydroxide solution (0.67 mL) were added. The reaction mixture was stirred at room temperature overnight. After completion of the reaction, it was quenched with water and extracted with ethyl acetate (EtOAc, 3 x 10 mL). The organic layers were combined, washed with saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by fast column chromatography (eluent: 0-60% ethyl acetate/hexane) to afford a light yellow oil (90 mg, 57% yield).1H NMR (400 MHz, CDCl3) δ 7.49 (d, J = 7.7 Hz, 1H), 6.89 (td, J = 8.0,1.4 Hz, 1H), 6.69-6.60 (m, 1H ), 6.55 (dd, J = 8.0,1.3Hz, 1H), 3.94 (s, 1H), 3.83-3.69 (m, 2H), 3.47-3.34 (m, 2H), 1.52 (s, 9H).
References
[1] Patent: WO2017/142883, 2017, A1. Location in patent: Paragraph 0225; 0227
[2] Patent: WO2016/86200, 2016, A1. Location in patent: Page/Page column 230; 231
[3] Patent: EP2172453, 2010, A1. Location in patent: Page/Page column 17
3,4-DIHYDRO-2H-QUINOXALINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
3,4-DIHYDRO-2H-QUINOXALINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers
- Tel
- +86-021-50935922
- Fax
- +86-021-33847795
- Country
- China
- ProdList
- 7865
- Advantage
- 55
- Tel
- 13052276172
- Fax
- 13052276172
- product@yuyuanpharm.com
- Country
- China
- ProdList
- 493
- Advantage
- 55
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 15136
- Advantage
- 55
- Tel
- 025-66028182 18626450290
- yftan@aikonchem.com
- Country
- China
- ProdList
- 16679
- Advantage
- 50
- Tel
- 0512-63009836 18994340901
- Fax
- 0512-63006936
- helen@struchem.com
- Country
- China
- ProdList
- 3981
- Advantage
- 60
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 0317-5296180 15533709196
- Fax
- 0317-5106596
- sale@enkepharma.com
- Country
- China
- ProdList
- 2267
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 021-021-021-31663258 13795219287
- Fax
- 021-31663258
- donghuanwen@126.com
- Country
- China
- ProdList
- 8816
- Advantage
- 58
- Tel
- 021-61469567 13482353728
- Fax
- 021-61161605
- sales@fdc-chemical.com
- Country
- China
- ProdList
- 9713
- Advantage
- 58
View Lastest Price from 3,4-DIHYDRO-2H-QUINOXALINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers
- Product
- TERT-BUTYL 3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE 887590-25-2
- Price
- US $1.10-9.90/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 100kg
- Release date
- 2025-08-18