3,4-DIHYDRO-2H-QUINOXALINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Product Name: 3,4-DIHYDRO-2H-QUINOXALINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CAS No.: 887590-25-2
Chemical Name: 3,4-DIHYDRO-2H-QUINOXALINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Synonyms: tert-butyl 3,4-dihydro-2H-quinoxaline-1-carboxylate;1-Boc-1,2,3,4-tetrahydroquinoxaline;tert-butyl 3,4-dihydroquinoxaline-1(2H)-carboxylat;ert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate;tert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate;TERT-BUTYL1,2,3,4-TETRAHYDROQUINOXALINE-1-CARBOXYLATE;3,4-DIHYDRO-2H-QUINOXALINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1(2H)-Quinoxalinecarboxylic acid, 3,4-dihydro-, 1,1-dimethylethyl ester
CBNumber: CB4354987
Molecular Formula: C13H18N2O2
Formula Weight: 234.29
MOL File: 887590-25-2.mol

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3,4-DIHYDRO-2H-QUINOXALINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Property

Boiling point:: 345.3±22.0 °C(Predicted)
Density: 1.112±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 3.27±0.70(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FB139572
Product name: tert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate
Packaging: 250mg
Price: $62.5
Updated: 2021/12/16

AK Scientific

Product number: 4607AC
Product name: tert-Butyl3,4-dihydroquinoxaline-1(2H)-carboxylate
Packaging: 1g
Price: $299
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB139572
Product name: tert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate
Packaging: 2g
Price: $324
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0394015
Product name: TERT-BUTYL-3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $498.78
Updated: 2021/12/16

Matrix Scientific

Product number: 089744
Product name: tert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate
Purity: 95+%
Packaging: 250mg
Price: $742
Updated: 2021/12/16

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3,4-DIHYDRO-2H-QUINOXALINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Synthesis

3476-89-9

24424-99-5

887590-25-2

GENERAL STEPS: Lithium aluminum hydride (LiAlH4, 228 mg, 6 mmol) was added batchwise to a stirred tetrahydrofuran (THF, 10 mL) solution of 1,2,3,4-tetrahydroquinoxaline (270 mg, 2 mmol) at 0 °C. The reaction mixture was stirred at 0 °C for 30 min, then brought to room temperature and stirred overnight. Upon completion of the reaction, the reaction was quenched sequentially by the addition of 0.25 mL of water, 0.25 mL of 5N sodium hydroxide solution and 1.25 mL of water. The insoluble material was removed by filtration and the filtrate was extracted with ethyl acetate (EtOAc, 3 x 20 mL). The organic layers were combined, washed with saturated saline, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The crude product was purified by fast column chromatography (eluent: 0-60% ethyl acetate/hexane) to give a light yellow solid (90 mg, 34% yield). The product obtained in the previous step (90 mg, 0.67 mmol) was dissolved in THF at 0 °C and di-tert-butyl dicarbonate (Boc2O, 146 mg, 0.67 mmol) and 1N aqueous sodium hydroxide solution (0.67 mL) were added. The reaction mixture was stirred at room temperature overnight. After completion of the reaction, it was quenched with water and extracted with ethyl acetate (EtOAc, 3 x 10 mL). The organic layers were combined, washed with saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by fast column chromatography (eluent: 0-60% ethyl acetate/hexane) to afford a light yellow oil (90 mg, 57% yield).1H NMR (400 MHz, CDCl3) δ 7.49 (d, J = 7.7 Hz, 1H), 6.89 (td, J = 8.0,1.4 Hz, 1H), 6.69-6.60 (m, 1H ), 6.55 (dd, J = 8.0,1.3Hz, 1H), 3.94 (s, 1H), 3.83-3.69 (m, 2H), 3.47-3.34 (m, 2H), 1.52 (s, 9H).

References

[1] Patent: WO2017/142883, 2017, A1. Location in patent: Paragraph 0225; 0227
[2] Patent: WO2016/86200, 2016, A1. Location in patent: Page/Page column 230; 231
[3] Patent: EP2172453, 2010, A1. Location in patent: Page/Page column 17

3,4-DIHYDRO-2H-QUINOXALINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3,4-DIHYDRO-2H-QUINOXALINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: TERT-BUTYL 3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE 887590-25-2
Price: US $1.10-9.90/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kg
Release date: 2025-08-18

887590-25-2, 3,4-DIHYDRO-2H-QUINOXALINE-1-CARBOXYLIC ACID TERT-BUTYL ESTERRelated Search:

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3,4-DIHYDRO-2H-QUINOXALINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

tert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate

TERT-BUTYL1,2,3,4-TETRAHYDROQUINOXALINE-1-CARBOXYLATE

tert-butyl 3,4-dihydro-2H-quinoxaline-1-carboxylate

1(2H)-Quinoxalinecarboxylic acid, 3,4-dihydro-, 1,1-dimethylethyl ester

ert-Butyl 3,4-dihydroquinoxaline-1(2H)-carboxylate

tert-butyl 3,4-dihydroquinoxaline-1(2H)-carboxylat

1-Boc-1,2,3,4-tetrahydroquinoxaline

887590-25-2

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