PLATELET ACTIVATING FACTOR-16, ANTAGONIST
- Product Name
- PLATELET ACTIVATING FACTOR-16, ANTAGONIST
- CAS No.
- 137566-83-7
- Chemical Name
- PLATELET ACTIVATING FACTOR-16, ANTAGONIST
- Synonyms
- HEXANOLAMINO PAF C-16;IJAODKNFSHBTDQ-SSEXGKCCSA-N;PLATELET ACTIVATING FACTOR-16, ANTAGONIST;1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphono(N,N,N-trimethyl)hexanolamine;1-O-HEXADECYL-2-ACETYL-SN-GLYCEROL-3-PHOSPHO-(N,N,N-TRIMETHYL)HEXANOLAMINE;1-O-HEXADECYL-2-ACETYL-SN-GLYCERO-3-PHOSPHO-(N,N,N-TRIMETHYL)-HEXANOLAMINE;1-O-HEXADECYL-2-O-ACETYL-SN-GLYCERO-3-PHOSPHO-(N,N,N-TRIMETHYL)HEXANOLAMINE;L-ALPHA-PHOSPHATIDYL(N,N,N-TRIMETHYL)HEXANOLAMINE, BETA-ACETYL, GAMMA-HEXADECYL;1-O-HEXADECYL-2-O-ACETYL-SN-GLYCERYL-3-PHOSPHORYL(N,N,N-TRIMETHYL) HEXANOLAMINE;7,9,13-Trioxa-8-phosphanonacosan-1-aminium, 11-(acetyloxy)-8-hydroxy-N,N,N-trimethyl-, inner salt, 8-oxide, (11R)-
- CBNumber
- CB8256061
- Molecular Formula
- C30H62NO7P
- Formula Weight
- 579.79
- MOL File
- 137566-83-7.mol
PLATELET ACTIVATING FACTOR-16, ANTAGONIST Property
- storage temp.
- −20°C
- solubility
- ≤23mg/ml in ethanol;0.5mg/ml in DMSO;1.5mg/ml in dimethyl formamide
- form
- lyophilized powder
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- 60905
- Product name
- Hexanolamino PAF C-16
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $28
- Updated
- 2024/03/01
- Product number
- 60905
- Product name
- Hexanolamino PAF C-16
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $117
- Updated
- 2024/03/01
- Product number
- 60905
- Product name
- Hexanolamino PAF C-16
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $207
- Updated
- 2024/03/01
- Product number
- 60905
- Product name
- Hexanolamino PAF C-16
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $448
- Updated
- 2024/03/01
- Product number
- C5373
- Product name
- HexanolaminoPAFC-16
- Packaging
- 25mg
- Price
- $510
- Updated
- 2021/12/16
PLATELET ACTIVATING FACTOR-16, ANTAGONIST Chemical Properties,Usage,Production
Uses
1-O-Hexadecyl-2-acetyl-sn-glycero-3-phospho-(N,N,N-trimethyl)-hexanolamine is a PAF antagonist.
Definition
ChEBI: 1-o-hexadecyl-2-o-acetyl-sn-glyceryl-3-phosphoryl(n,n,n-trimethyl)hexanolamine is a glycerophospholipid.
Biological Activity
hexanolamino paf c-16 is a paf analog with paf agonist/antagonist properties.platelet activating factor (paf; c16), a phospholipid mediator of inflammation, is secreted by several cell types including arterial endothelial cells, and can activate polymorphonuclear leucocytes and monocytes via specific cell surface receptors. paf also stimulates the production of active oxygen species by human monocyte - derived macrophages [1].hexanolamino paf c-16, a paf analog with an increased inter-ionic distance in the polar head group, showed a greater potency in macrophages than platelets. in human monocyte-derived macrophages, hexanolamino paf c-16 was an antagonist and specifically inhibited the generation of superoxide ion (02-) and hydrogen peroxide (h202) in response to paf [1]. in both rabbit platelets and guinea-pig macrophages, hexanolamino paf c-16 acted as a partial agonist [2].
References
[1]. rouis m, nigon f, chapman mj. platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages. biochem biophys res commun. 1988 nov 15;156(3):1293-301.
[2]. stewart ag, grigoriadis g. structure-activity relationships for platelet-activating factor (paf) and analogues reveal differences between paf receptors on platelets and macrophages. j lipid mediat. 1991 nov;4(3):299-308.
PLATELET ACTIVATING FACTOR-16, ANTAGONIST Preparation Products And Raw materials
Raw materials
Preparation Products
PLATELET ACTIVATING FACTOR-16, ANTAGONIST Suppliers
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