PLATELET ACTIVATING FACTOR-16, ANTAGONIST

Product Name: PLATELET ACTIVATING FACTOR-16, ANTAGONIST
CAS No.: 137566-83-7
Chemical Name: PLATELET ACTIVATING FACTOR-16, ANTAGONIST
Synonyms: HEXANOLAMINO PAF C-16;IJAODKNFSHBTDQ-SSEXGKCCSA-N;PLATELET ACTIVATING FACTOR-16, ANTAGONIST;1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphono(N,N,N-trimethyl)hexanolamine;1-O-HEXADECYL-2-ACETYL-SN-GLYCEROL-3-PHOSPHO-(N,N,N-TRIMETHYL)HEXANOLAMINE;1-O-HEXADECYL-2-ACETYL-SN-GLYCERO-3-PHOSPHO-(N,N,N-TRIMETHYL)-HEXANOLAMINE;1-O-HEXADECYL-2-O-ACETYL-SN-GLYCERO-3-PHOSPHO-(N,N,N-TRIMETHYL)HEXANOLAMINE;L-ALPHA-PHOSPHATIDYL(N,N,N-TRIMETHYL)HEXANOLAMINE, BETA-ACETYL, GAMMA-HEXADECYL;1-O-HEXADECYL-2-O-ACETYL-SN-GLYCERYL-3-PHOSPHORYL(N,N,N-TRIMETHYL) HEXANOLAMINE;7,9,13-Trioxa-8-phosphanonacosan-1-aminium, 11-(acetyloxy)-8-hydroxy-N,N,N-trimethyl-, inner salt, 8-oxide, (11R)-
CBNumber: CB8256061
Molecular Formula: C30H62NO7P
Formula Weight: 579.79
MOL File: 137566-83-7.mol

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PLATELET ACTIVATING FACTOR-16, ANTAGONIST Property

storage temp.: −20°C
solubility: ≤23mg/ml in ethanol;0.5mg/ml in DMSO;1.5mg/ml in dimethyl formamide
form: lyophilized powder

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 60905
Product name: Hexanolamino PAF C-16
Purity: ≥98%
Packaging: 1mg
Price: $28
Updated: 2024/03/01

Cayman Chemical

Product number: 60905
Product name: Hexanolamino PAF C-16
Purity: ≥98%
Packaging: 5mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 60905
Product name: Hexanolamino PAF C-16
Purity: ≥98%
Packaging: 10mg
Price: $207
Updated: 2024/03/01

Cayman Chemical

Product number: 60905
Product name: Hexanolamino PAF C-16
Purity: ≥98%
Packaging: 25mg
Price: $448
Updated: 2024/03/01

ApexBio Technology

Product number: C5373
Product name: HexanolaminoPAFC-16
Packaging: 25mg
Price: $510
Updated: 2021/12/16

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PLATELET ACTIVATING FACTOR-16, ANTAGONIST Chemical Properties,Usage,Production

Uses

1-O-Hexadecyl-2-acetyl-sn-glycero-3-phospho-(N,N,N-trimethyl)-hexanolamine is a PAF antagonist.

Definition

ChEBI: 1-o-hexadecyl-2-o-acetyl-sn-glyceryl-3-phosphoryl(n,n,n-trimethyl)hexanolamine is a glycerophospholipid.

Biological Activity

hexanolamino paf c-16 is a paf analog with paf agonist/antagonist properties.platelet activating factor (paf; c16), a phospholipid mediator of inflammation, is secreted by several cell types including arterial endothelial cells, and can activate polymorphonuclear leucocytes and monocytes via specific cell surface receptors. paf also stimulates the production of active oxygen species by human monocyte - derived macrophages [1].hexanolamino paf c-16, a paf analog with an increased inter-ionic distance in the polar head group, showed a greater potency in macrophages than platelets. in human monocyte-derived macrophages, hexanolamino paf c-16 was an antagonist and specifically inhibited the generation of superoxide ion (02-) and hydrogen peroxide (h202) in response to paf [1]. in both rabbit platelets and guinea-pig macrophages, hexanolamino paf c-16 acted as a partial agonist [2].

References

[1]. rouis m, nigon f, chapman mj. platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages. biochem biophys res commun. 1988 nov 15;156(3):1293-301.
[2]. stewart ag, grigoriadis g. structure-activity relationships for platelet-activating factor (paf) and analogues reveal differences between paf receptors on platelets and macrophages. j lipid mediat. 1991 nov;4(3):299-308.

PLATELET ACTIVATING FACTOR-16, ANTAGONIST Preparation Products And Raw materials

Raw materials

Preparation Products

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PLATELET ACTIVATING FACTOR-16, ANTAGONIST Suppliers

China 4 Switzerland 3 United Kingdom 2 United States 6 Global 15

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IJAODKNFSHBTDQ-SSEXGKCCSA-N

7,9,13-Trioxa-8-phosphanonacosan-1-aminium, 11-(acetyloxy)-8-hydroxy-N,N,N-trimethyl-, inner salt, 8-oxide, (11R)-

137566-83-7

C30H62NO7P