ChemicalBook > CAS DataBase List > 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate hydrate

4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate hydrate

Product Name
4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate hydrate
CAS No.
915967-82-7
Chemical Name
4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate hydrate
Synonyms
Piperaquine tetraphosphate tetrahydrate;1,3-Bis[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propane Tetraphosphate;1,3-Bis[4-(7-chloro-4-quinolinyl)-1-piperazinyl]propane tetraphosphate tetrahydrate;4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate hydrate;1,3-Bis(4-(7-chloroquinolin-4-yl)piperazin-1-yl)propane tetrakis(phosphate) tetrahydrate;artemisinin,Parasite,inhibit,antimalarial,drug-based,Inhibitor,Piperaquine tetraphosphate tetrahydrate,ACT,combination
CBNumber
CB82565923
Molecular Formula
C29H32Cl2N6.4(H3PO4).4(H2O)
Formula Weight
651.521041
MOL File
915967-82-7.mol
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4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate hydrate Property

Melting point:
252 °C(dec.)
storage temp. 
room temp
solubility 
H2O: ≥10mg/mL
form 
Powder
color 
white to off-white
Water Solubility 
H2O: ≥10mg/mL
Sensitive 
Hygroscopic
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
HS Code 
2933.59.8000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C7874
Product name
Piperaquine tetraphosphate tetrahydrate
Purity
≥98% (HPLC)
Packaging
5mg
Price
$131.1
Updated
2025/07/31
Sigma-Aldrich
Product number
C7874
Product name
Piperaquine tetraphosphate tetrahydrate
Purity
≥98% (HPLC)
Packaging
25mg
Price
$560
Updated
2025/07/31
TCI Chemical
Product number
P1987
Product name
Piperaquine Tetraphosphate Tetrahydrate
Packaging
5G
Price
$61
Updated
2025/07/31
TCI Chemical
Product number
P1987
Product name
Piperaquine Tetraphosphate Tetrahydrate
Packaging
25G
Price
$205
Updated
2025/07/31
ChemScene
Product number
CS-0089881
Product name
Piperaquine Tetraphosphate Tetrahydrate
Purity
>98.0%
Packaging
25mg
Price
$180
Updated
2021/12/16
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4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate hydrate Chemical Properties,Usage,Production

Uses

Piperaquine tetraphosphate tetrahydrate has been used to study its effect on the tert-butylhydroperoxide (t-BHP)-induced alterations of cell morphology and viability

Biochem/physiol Actions

Piperaquine tetraphosphate tetrahydrate is an antimalarial agent highly active against chloroquine-resistant Plasmodium falciparum and Plasmodium vivax.

in vivo

Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia at all of the doses tested in mice[1].
Piperaquine (90 mg/kg; a single i.p.) exhibits the t1/2, apparent clearance, and apparent volume of distribution 17.8 days, 33.5 mg h/L, 1.55 L/h/kg, and 956 L/kg, respectively, in healthy mice and 16.1 days, 27.3 mg h/L, 1.9 L/h/kg, and 1,059 L/kg in malaria-infected mice[1].

Animal Model:Male BALB/c mice (7 to 8 weeks) are inoculated with Plasmodium berghei parasites[1]
Dosage:0, 10, 30, 90 mg/kg
Administration:A single i.p. administration
Result:The median survival time was 10 days at dose of 10 mg/kg.
The median survival time was 54 days at dose of 30 mg/kg.
All mice were active and alert and had stable body weights throughout the course of the study at dose of 90 mg/kg.
Animal Model:Male Swiss mice (6 weeks old)[1]
Dosage:90 mg/kg (Pharmacokinetic Analysis)
Administration:A single i.p. administration
Result:t1/2=17.8 d; AUC=33.5 mg?h/L; apparent clearance=1.55 L/h/kg; apparent volume of distribution=956 L/kg.

IC 50

Plasmodium

4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate hydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate hydrate Suppliers

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915967-82-7, 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate hydrateRelated Search:


  • 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate hydrate
  • Piperaquine tetraphosphate tetrahydrate
  • 1,3-Bis[4-(7-chloro-4-quinolinyl)-1-piperazinyl]propane tetraphosphate tetrahydrate
  • 1,3-Bis[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propane Tetraphosphate
  • artemisinin,Parasite,inhibit,antimalarial,drug-based,Inhibitor,Piperaquine tetraphosphate tetrahydrate,ACT,combination
  • 1,3-Bis(4-(7-chloroquinolin-4-yl)piperazin-1-yl)propane tetrakis(phosphate) tetrahydrate
  • 915967-82-7