4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate hydrate
- Product Name
- 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate hydrate
- CAS No.
- 915967-82-7
- Chemical Name
- 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate hydrate
- Synonyms
- Piperaquine tetraphosphate tetrahydrate;1,3-Bis[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propane Tetraphosphate;1,3-Bis[4-(7-chloro-4-quinolinyl)-1-piperazinyl]propane tetraphosphate tetrahydrate;4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate hydrate;1,3-Bis(4-(7-chloroquinolin-4-yl)piperazin-1-yl)propane tetrakis(phosphate) tetrahydrate;artemisinin,Parasite,inhibit,antimalarial,drug-based,Inhibitor,Piperaquine tetraphosphate tetrahydrate,ACT,combination
- CBNumber
- CB82565923
- Molecular Formula
- C29H32Cl2N6.4(H3PO4).4(H2O)
- Formula Weight
- 651.521041
- MOL File
- 915967-82-7.mol
4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate hydrate Property
- Melting point:
- 252 °C(dec.)
- storage temp.
- room temp
- solubility
- H2O: ≥10mg/mL
- form
- Powder
- color
- white to off-white
- Water Solubility
- H2O: ≥10mg/mL
- Sensitive
- Hygroscopic
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C7874
- Product name
- Piperaquine tetraphosphate tetrahydrate
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $131.1
- Updated
- 2025/07/31
- Product number
- C7874
- Product name
- Piperaquine tetraphosphate tetrahydrate
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $560
- Updated
- 2025/07/31
- Product number
- P1987
- Product name
- Piperaquine Tetraphosphate Tetrahydrate
- Packaging
- 5G
- Price
- $61
- Updated
- 2025/07/31
- Product number
- P1987
- Product name
- Piperaquine Tetraphosphate Tetrahydrate
- Packaging
- 25G
- Price
- $205
- Updated
- 2025/07/31
- Product number
- CS-0089881
- Product name
- Piperaquine Tetraphosphate Tetrahydrate
- Purity
- >98.0%
- Packaging
- 25mg
- Price
- $180
- Updated
- 2021/12/16
4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate hydrate Chemical Properties,Usage,Production
Uses
Piperaquine tetraphosphate tetrahydrate has been used to study its effect on the tert-butylhydroperoxide (t-BHP)-induced alterations of cell morphology and viability
Biochem/physiol Actions
Piperaquine tetraphosphate tetrahydrate is an antimalarial agent highly active against chloroquine-resistant Plasmodium falciparum and Plasmodium vivax.
in vivo
Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia at all of the doses tested in mice[1].
Piperaquine (90 mg/kg; a single i.p.) exhibits the t1/2, apparent clearance, and apparent volume of distribution 17.8 days, 33.5 mg h/L, 1.55 L/h/kg, and 956 L/kg, respectively, in healthy mice and 16.1 days, 27.3 mg h/L, 1.9 L/h/kg, and 1,059 L/kg in malaria-infected mice[1].
| Animal Model: | Male BALB/c mice (7 to 8 weeks) are inoculated with Plasmodium berghei parasites[1] |
| Dosage: | 0, 10, 30, 90 mg/kg |
| Administration: | A single i.p. administration |
| Result: | The median survival time was 10 days at dose of 10 mg/kg. The median survival time was 54 days at dose of 30 mg/kg. All mice were active and alert and had stable body weights throughout the course of the study at dose of 90 mg/kg. |
| Animal Model: | Male Swiss mice (6 weeks old)[1] |
| Dosage: | 90 mg/kg (Pharmacokinetic Analysis) |
| Administration: | A single i.p. administration |
| Result: | t1/2=17.8 d; AUC=33.5 mg?h/L; apparent clearance=1.55 L/h/kg; apparent volume of distribution=956 L/kg. |
IC 50
Plasmodium
4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate hydrate Preparation Products And Raw materials
Raw materials
Preparation Products
4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate hydrate Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80