Methyl 3,4-dichlorophenylacetate
- Product Name
- Methyl 3,4-dichlorophenylacetate
- CAS No.
- 6725-44-6
- Chemical Name
- Methyl 3,4-dichlorophenylacetate
- Synonyms
- METHYL 3,4-DICHLOROPHENYLACETATE;Methyl 3,4-dichlorobenzeneacetate;Methyl3,4-Dichlorophenylacetate>Methyl2-(3,4-dichlorophenyl)acetate;Methyl 3,4-dichlorophenylacetate,99%;Methyl 3,4-dichlorophenylacetate, 97+%;Dichlorophenyl acetic acid methyl ester;3,4-DICHLOROPHENYLACETIC ACID METHYL ESTER;2-(3,4-dichlorophenyl)acetic acid methyl ester;Benzeneacetic acid, 3,4-dichloro-, methyl ester
- CBNumber
- CB8256960
- Molecular Formula
- C9H8Cl2O2
- Formula Weight
- 219.06
- MOL File
- 6725-44-6.mol
Methyl 3,4-dichlorophenylacetate Property
- Melting point:
- 25-27
- Boiling point:
- 314.25°C (rough estimate)
- Density
- 1.54-1.542
- refractive index
- 1.54-1.542
- storage temp.
- Sealed in dry,Room Temperature
- form
- Liquid After Melting
- color
- Clear colorless to light yellow
- CAS DataBase Reference
- 6725-44-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 24/25-37-26
- Hazard Note
- Irritant
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M2557
- Product name
- Methyl 3,4-Dichlorophenylacetate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $89
- Updated
- 2025/07/31
- Product number
- M2557
- Product name
- Methyl 3,4-Dichlorophenylacetate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $354
- Updated
- 2025/07/31
- Product number
- M301380
- Product name
- Methyl 3,4-Dichlorophenylacetate
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- OR0617
- Product name
- Methyl 3,4-Dichlorophenylacetate
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- OR0617
- Product name
- Methyl 3,4-Dichlorophenylacetate
- Packaging
- 10g
- Price
- $24
- Updated
- 2021/12/16
Methyl 3,4-dichlorophenylacetate Chemical Properties,Usage,Production
Chemical Properties
clear colorless liquid
Synthesis
67-56-1
5807-30-7
6725-44-6
The general procedure for synthesizing methyl 3,4-dichlorophenylacetate from methanol and 3,4-dichlorophenylacetic acid was as follows: referring to Synthesis Example 1, methanol (59 mL, 3.0 equiv) was added to a solution of 1,2-dichloroethane (400 mL) containing 3,4-dichlorophenylacetic acid (100 g, 0.488 mol). The mixed solution was heated to 50 °C, followed by the slow dropwise addition of concentrated sulfuric acid (10 mL) over 15 min. After the dropwise addition was completed, the reaction temperature was maintained at 50°C and stirring was continued for 1.5 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature and a partitioning operation was performed to separate and remove the sulfuric acid layer. The resulting organic layer was washed sequentially with water, saturated aqueous sodium bicarbonate solution and saturated brine, followed by drying with anhydrous magnesium sulfate. After drying, the desiccant was removed by filtration and the solvent was removed by distillation, resulting in the target product methyl 3,4-dichlorophenylacetate (105 g, yield: 98%) in the form of colorless oil. The structure of the product was confirmed by 1H-NMR (300 MHz, CDCl3) with chemical shifts δ: 3.59 (s, 2H), 3.71 (s, 3H), 7.12 (dd, J = 8.4 Hz, 1.8 Hz, 1H), 7.38-7.41 (m, 2H).
References
[1] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 13, p. 2843 - 2866
[2] Journal of Medicinal Chemistry, 2001, vol. 44, # 17, p. 2701 - 2706
[3] Journal of Medicinal Chemistry, 2010, vol. 53, # 9, p. 3618 - 3625
[4] Patent: US2003/225283, 2003, A1. Location in patent: Page 12-13
[5] Patent: EP2246343, 2010, A1. Location in patent: Page/Page column 10
Methyl 3,4-dichlorophenylacetate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 3,4-dichlorophenylacetate manufacturers
- Product
- Methyl 3,4-dichlorophenylacetate 6725-44-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 85.0-99.8%
- Supply Ability
- 20tons
- Release date
- 2020-01-08