3-[[(tert-Butoxy)carbonyl]amino]-5-fluoro-4-oxopentanoic acid methyl ester
- Product Name
- 3-[[(tert-Butoxy)carbonyl]amino]-5-fluoro-4-oxopentanoic acid methyl ester
- CAS No.
- 634911-80-1
- Chemical Name
- 3-[[(tert-Butoxy)carbonyl]amino]-5-fluoro-4-oxopentanoic acid methyl ester
- Synonyms
- abs818554;BOC-D-FMK, 10 mM in DMSO;Caspase Inhibitor Boc-D-FMK;Caspase3-Inhibitor Boc-D-FMK;1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-;BOCDFMK,Inhibitor,inhibit,Caspase,Apoptosis,BOC D FMK;BOC-d-FMK /PAN-CASPASE INHIBITOR BOC-D-FMK / 634911-80-1;Methyl 3-((tert-butoxycarbonyl)amino)-5-fluoro-4-oxopentanoate;3-[[(tert-Butoxy)carbonyl]amino]-5-fluoro-4-oxopentanoic acid methyl ester;Pentanoic acid, 3-[[(1,1-diMethylethoxy)carbonyl]aMino]-5-fluoro-4-oxo-, Methyl ester
- CBNumber
- CB82589624
- Molecular Formula
- C11H18FNO5
- Formula Weight
- 263.26
- MOL File
- 634911-80-1.mol
3-[[(tert-Butoxy)carbonyl]amino]-5-fluoro-4-oxopentanoic acid methyl ester Property
- Boiling point:
- 383.5±37.0 °C(Predicted)
- Density
- 1.150
- storage temp.
- -20°C
- solubility
- DMSO: 5mg/mL
- form
- <31.2°C Solid,>31.2°C Liquid
- pka
- 10.12±0.46(Predicted)
- color
- Light yellow to yellow
- InChI
- InChI=1S/C11H18FNO5/c1-11(2,3)18-10(16)13-7(8(14)6-12)5-9(15)17-4/h7H,5-6H2,1-4H3,(H,13,16)
- InChIKey
- MXOOUCRHWJYCAL-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)CC(NC(OC(C)(C)C)=O)C(=O)CF
N-Bromosuccinimide Price
- Product number
- 218745
- Product name
- Caspase Inhibitor III - CAS 634911-80-1 - Calbiochem
- Purity
- The Caspase Inhibitor III, also referenced under CAS 634911-80-1, controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications.
- Packaging
- 250μG
- Price
- $102
- Updated
- 2025/07/31
- Product number
- 218745
- Product name
- Caspase Inhibitor III - CAS 634911-80-1 - Calbiochem
- Purity
- The Caspase Inhibitor III, also referenced under CAS 634911-80-1, controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications.
- Packaging
- 1MG
- Price
- $272
- Updated
- 2024/03/01
- Product number
- CD31001218
- Product name
- BOC-D-FMK
- Purity
- 98+%
- Packaging
- 5mg
- Price
- $98
- Updated
- 2021/12/16
- Product number
- CD31001218
- Product name
- BOC-D-FMK
- Purity
- 98+%
- Packaging
- 10mg
- Price
- $146
- Updated
- 2021/12/16
- Product number
- DC23218
- Product name
- BOC-D-FMK
- Purity
- >98%
- Packaging
- 100mg
- Price
- $500
- Updated
- 2021/12/16
3-[[(tert-Butoxy)carbonyl]amino]-5-fluoro-4-oxopentanoic acid methyl ester Chemical Properties,Usage,Production
Uses
Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor. Boc-D-FMK inhibits apoptosis stimulated by TNF-α with an IC50 of 39 μM.
Biological Activity
Cell permeable: yes', 'Primary Target
broad spectrum caspase', 'Product does not compete with ATP.', 'Reversible: no
in vivo
Boc-D-FMK-fmk effectively attenuates the hepatocyte apoptosis in bile duct-ligated rats and may improve the survival rates after endotoxin challenge[3]. A single injection of Boc-D-FMK results in longterm protection of MNs against root avulsion-induced death for more than 8 weeks and the Boc-D-FMK-treated MNs are able to regenerate their axons into an implanted PN graft and reinnervate the target muscle[4].
IC 50
Caspase
References
[1] Cowburn AS, et al. z-VAD-fmk augmentation of TNF alpha-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species. DOI:10.1182/blood-2004-07-2870
[2] Yee SB, et al. zVAD-fmk, unlike BocD-fmk, does not inhibit caspase-6 acting on 14-3-3/Bad pathway in apoptosis of p815 mastocytoma cells. Exp Mol Med. 2006 Dec 31;38(6):634-42. DOI:10.1038/emm.2006.75
[3] Sheen-Chen SM, et al. Effect of Boc-D-Fmk on hepatocyte apoptosis after bile duct ligation in rat and survival rate after endotoxin challenge. J Gastroenterol Hepatol. 2008 Aug;23(8 Pt 1):1276-9. DOI:10.1111/j.1440-1746.2008.05368.x
[4] Chan YM, et al. Inhibition of caspases promotes long-term survival and reinnervation by axotomized spinal motoneurons of denervated muscle in newborn rats. Exp Neurol. 2003 Jun;181(2):190-203. DOI:10.1016/s0014-4886(03)00023-2
3-[[(tert-Butoxy)carbonyl]amino]-5-fluoro-4-oxopentanoic acid methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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