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GSK-3 Inhibitor X

Product Name
GSK-3 Inhibitor X
CAS No.
740841-15-0
Chemical Name
GSK-3 Inhibitor X
Synonyms
(E/Z)-BIO-acetoxime;GSK-3 Inhibitor X - CAS 740841-15-0 - Calbiochem;2H-Indol-2-one, 3-[3-[(acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-
CBNumber
CB82602842
Molecular Formula
C18H12BrN3O3
Formula Weight
398.21
MOL File
740841-15-0.mol
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GSK-3 Inhibitor X Property

storage temp. 
+2C to +8C
solubility 
DMF: 10 mg/ml; DMSO: 10 mg/ml
form 
Dark purple solid
color 
dark purple
Sensitive 
Light Sensitive
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
361551
Product name
GSK-3 Inhibitor X - CAS 740841-15-0 - Calbiochem
Packaging
1mg
Price
$177
Updated
2025/07/31
Cayman Chemical
Product number
16329
Product name
BIO-Acetoxime
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
16329
Product name
BIO-Acetoxime
Purity
≥95%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
16329
Product name
BIO-Acetoxime
Purity
≥95%
Packaging
10mg
Price
$243
Updated
2024/03/01
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GSK-3 Inhibitor X Chemical Properties,Usage,Production

Uses

(E/Z)-BIO-acetoxime (GSK-3 Inhibitor X) is a potent and selective GSK-3α/β inhibitor, with an IC50 of 10 nM. (E/Z)-BIO-acetoxime shows more than 200-flod selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B (IC50=2.4, 4.3, 63 μM)[1].

General Description

An acetoxime analog of BIO, GSK-3 Inhibitor IX (Cat. No. 361550) that exhibits greater selectivity for GSK-3α/β (IC50 = 10 nM) over Cdk5/p25, Cdk2/cyclin A, and Cdk1/cyclin B (IC50 = 2.4 μM, 4.3 μM, and 63 μM, respectively). A weak inhibitor of Cdk4/cyclin D1 and many other non-related kinases (IC50 ≥ 10 μM). Yields BIO (Cat. No. 361550) upon hydrolysis.

Biochem/physiol Actions

Product does not compete with ATP.

IC 50

GSK-3α: 10 nM (IC50); GSK-3β: 10 nM (IC50); Cdk5/p25: 2.4 μM (IC50); CDK2/cyclinA: 4.3 μM (IC50); CDK1/cyclinB: 63 μM (IC50)

References

[1] Meijer L, et, al. GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol. 2003 Dec;10(12):1255-66. DOI:10.1016/j.chembiol.2003.11.010

GSK-3 Inhibitor X Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK-3 Inhibitor X Suppliers

China 14 United States 6 Global 20
VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
ProdList
510
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64
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Creative Enzymes
Tel
--
Fax
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Email
info@creative-enzymes.com
Country
United States
ProdList
6057
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58
Riedel-de Haen AG
Tel
--
Fax
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Country
United States
ProdList
6773
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740841-15-0, GSK-3 Inhibitor XRelated Search:


  • GSK-3 Inhibitor X - CAS 740841-15-0 - Calbiochem
  • 2H-Indol-2-one, 3-[3-[(acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-
  • (E/Z)-BIO-acetoxime
  • 740841-15-0
  • Other Enzyme Inhibitors and Activators.