(R)-2-ethylpyrrolidine hydrochloride
- Product Name
- (R)-2-ethylpyrrolidine hydrochloride
- CAS No.
- 460748-80-5
- Chemical Name
- (R)-2-ethylpyrrolidine hydrochloride
- Synonyms
- (2R)-2-ETHYL-PYRROLIDINE HCL;(2R)-Ethylpyrrolidine hydrochloride;(R)-2-ethylpyrrolidine hydrochloride;(2R)-2-Ethylpyrrolidine Hydrochloride
- CBNumber
- CB82604578
- Molecular Formula
- C6H14ClN
- Formula Weight
- 135.64
- MOL File
- 460748-80-5.mol
(R)-2-ethylpyrrolidine hydrochloride Property
- storage temp.
- Inert atmosphere,Room Temperature
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E818075
- Product name
- (2R)-EthylpyrrolidineHydrochloride
- Packaging
- 2.5g
- Price
- $1260
- Updated
- 2021/12/16
- Product number
- 8110DT
- Product name
- (R)-2-Ethylpyrrolidinehydrochloride
- Packaging
- 5g
- Price
- $1342
- Updated
- 2021/12/16
- Product number
- 8110DT
- Product name
- (R)-2-Ethylpyrrolidinehydrochloride
- Packaging
- 250mg
- Price
- $282
- Updated
- 2021/12/16
- Product number
- 8110DT
- Product name
- (R)-2-Ethylpyrrolidinehydrochloride
- Packaging
- 1g
- Price
- $492
- Updated
- 2021/12/16
- Product number
- CCH0032851
- Product name
- (R)-2-ETHYLPYRROLIDINE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.66
- Updated
- 2021/12/16
(R)-2-ethylpyrrolidine hydrochloride Chemical Properties,Usage,Production
Uses
(2R)-Ethylpyrrolidine Hydrochloride is used as a reagent in the synthesis of 6-(4-pyrimidinyl)-1H-indazole derivatives as PDK1 kinase inhibitors useful in treatment of cancer, immune, metabolic and other kinase-mediated diseases. Also used as a reagent in the synthesis of aryloxazole derivatives as histamine H3 receptor antagonists or inverse agonists.
Synthesis
1227910-54-4
460748-80-5
In a sealable reaction tube, phenylmethyl (2R)-2-ethyl-1-pyrrolidinecarboxylate (230 mg, 0.99 mmol) was dissolved in a solvent mixture of 1,4-dioxane (6 mL) and concentrated hydrochloric acid (4 mL). After sealing the reaction tube, the reaction mixture was stirred at 90°C for 5 hours. Upon completion of the reaction, the solution was concentrated and the residue was azeotropized by toluene (~20 mL) to remove residual water. Subsequently, ether (Et2O) was added to the residue and the mixture was sonicated and decanted. The solid obtained was dissolved in acetonitrile (CH3CN) and ether was added dropwise until a precipitate was generated. The mixture was again sonicated and decanted, and the solid was ground with ether to give (R)-2-ethylpyrrolidine hydrochloride (80 mg, 60% yield) as an off-white solid. The product was characterized by 1H NMR (400 MHz, CD3OD): δ 1.07 (t, J = 7.5 Hz, 3H), 1.60-1.84 (m, 3H), 1.96-2.17 (m, 2H), 2.19-2.31 (m, 1H), 3.30 (m, 2H), 3.38-3.52 (m, 1H).
References
[1] Patent: WO2010/120854, 2010, A1. Location in patent: Page/Page column 55
(R)-2-ethylpyrrolidine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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