3-(2-fluoro-4-iodophenylaMino)isonicotinic acid
- Product Name
- 3-(2-fluoro-4-iodophenylaMino)isonicotinic acid
- CAS No.
- 885588-03-4
- Chemical Name
- 3-(2-fluoro-4-iodophenylaMino)isonicotinic acid
- Synonyms
- 100537;3-(2-fluoro-4-iodophenylaMino)isonicotinic acid;3-(2-Fluoro-4-iodoanilino)pyridine-4-carboxylic acid;4-Pyridinecarboxylic acid, 3-[(2-fluoro-4-iodophenyl)amino]-
- CBNumber
- CB82604644
- Molecular Formula
- C12H8FIN2O2
- Formula Weight
- 358.11
- MOL File
- 885588-03-4.mol
3-(2-fluoro-4-iodophenylaMino)isonicotinic acid Property
- Boiling point:
- 484.8±45.0 °C(Predicted)
- Density
- 1.909±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 1.39±0.36(Predicted)
- Appearance
- Light brown to gray Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-B0946
- Product name
- 3-[(2-Fluoro-4-iodophenyl)amino]isonicotinicacid
- Packaging
- 100mg
- Price
- $74
- Updated
- 2021/12/16
- Product number
- CS-B0946
- Product name
- 3-[(2-Fluoro-4-iodophenyl)amino]isonicotinicacid
- Packaging
- 250mg
- Price
- $114
- Updated
- 2021/12/16
- Product number
- CS-B0946
- Product name
- 3-[(2-Fluoro-4-iodophenyl)amino]isonicotinicacid
- Packaging
- 1g
- Price
- $280
- Updated
- 2021/12/16
- Product number
- 090048
- Product name
- 3-((2-Fluoro-4-iodophenyl)amino)isonicotinic acid
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $416
- Updated
- 2021/12/16
- Product number
- HCH0364018
- Product name
- 3-((2-FLUORO-4-IODOPHENYL)AMINO)ISONICOTINIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.6
- Updated
- 2021/12/16
3-(2-fluoro-4-iodophenylaMino)isonicotinic acid Chemical Properties,Usage,Production
Synthesis
393-53-3
885588-03-4
The general procedure for the synthesis of 3-(2-fluoro-4-iodophenylamino)-4-carboxylic acid pyridine from 3-fluoroisonicotinic acid is as follows: Intermediate 1: Synthesis of 3-(2-fluoro-4-iodophenylamino)-isonicotinic acid: 4-Iodo-2-fluoroaniline (20.0 g, 84.38 mmol) was dissolved in anhydrous tetrahydrofuran (80 mL) under inert atmosphere and cooled to -65 °C. Subsequently, 1.0 M bis(trimethylsilyl)aminolithium tetrahydrofuran solution (255 mL, 255 mmol) was slowly added, keeping the reaction temperature below -55 °C. After addition, the reaction mixture was stirred for 30 min, then 3-fluoroisonicotinic acid (8.0 g, 56.69 mmol) was added. The reaction mixture was stirred at room temperature for 4 days. After the reaction was completed, the mixture was poured into 2.0 N aqueous sodium hydroxide solution (1000 mL) and ethyl acetate (250 mL). The organic and aqueous layers were separated and the aqueous layer was further extracted from the organic phase with aqueous sodium hydroxide solution (2 x 1000 mL). The aqueous phase was combined and the pH was adjusted to 2 with concentrated hydrochloric acid to precipitate the target product. The solid was collected by filtration, washed with water (300 mL) and dried under high vacuum at 40 °C for 18 h to afford the yellow solid product 3-(2-fluoro-4-iodophenylamino)-isonicotinic acid (19.05 g, 53.19 mmol, 94% yield). Mass spectrum (MS): [M+1] 359. 1H NMR (400 MHz, DMSO-D6): δ 7.3565 (t, J = 8.8 Hz, 1H), 7.5509 (d, J = 8.4 Hz, 1H), 7.7521 (m, 2H), 8.1175 (d, J = 4.7 Hz, 1H), 8.4472 (s, 1H), 9.2184 (s, 1H).
References
[1] Patent: WO2007/123936, 2007, A1. Location in patent: Page/Page column 36
3-(2-fluoro-4-iodophenylaMino)isonicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-(2-fluoro-4-iodophenylaMino)isonicotinic acid manufacturers
- Product
- 3-(2-fluoro-4-iodophenylaMino)isonicotinic acid 885588-03-4
- Price
- US $1.00/KG
- Min. Order
- 1G
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-08-17