Icotinib

Uses

Product Name: Icotinib
CAS No.: 610798-31-7
Chemical Name: Icotinib
Synonyms: ConMana;N-(3-Ethynylphenyl)-7,8,10,11,13,14-hexahydro-[1,4,7,10]tetraoxacyclododecino[2,3-g]quinazolin-4-amine;CS-908;otinib;BP-1096;Icotinib;Lcotinib;BPI-2009;BPI-2009H;Icotinib BP-1096
CBNumber: CB82616025
Molecular Formula: C22H21N3O4
Formula Weight: 391.42
MOL File: 610798-31-7.mol

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Icotinib Property

Boiling point:: 581℃
Density: 1.31
Flash point:: 305℃
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥129.6 mg/mL in DMSO; ≥14.13 mg/mL in EtOH with ultrasonic
form: Powder
pka: 5.32±0.20(Predicted)
color: White to off-white

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Safety

HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Activate Scientific

Product number: AS117640
Product name: Icotinib
Purity: 98+%
Packaging: 1mg
Price: $52
Updated: 2021/12/16

ChemScene

Product number: CS-2017
Product name: Icotinib
Purity: 99.79%
Packaging: 5mg
Price: $70
Updated: 2021/12/16

ChemScene

Product number: CS-2017
Product name: Icotinib
Purity: 99.79%
Packaging: 10mg
Price: $100
Updated: 2021/12/16

Activate Scientific

Product number: AS117640
Product name: Icotinib
Purity: 98+%
Packaging: 5mg
Price: $136
Updated: 2021/12/16

AK Scientific

Product number: 2468AH
Product name: Icotinib
Packaging: 5mg
Price: $153
Updated: 2021/12/16

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Icotinib Chemical Properties,Usage,Production

Uses

Icotinib is a highly selective, 1st generation EGFR-TKI (epidermal growth factor receptor tyrosine kinase) inhibitor. The mutations of EGFR is associated with many kinds of cancers. Currently, Icotinib is under investigation for its treatment efficacy on some cancer such as non-small cell lung cancer. Icotinib take effects through binding reversibly to the ATP binding site of the EGFR protein, further preventing completion of the signal transduction cascade.

Description

Icotinib is also known as ConMana. It is a highly selective, first-generation inhibitor of epidermal growth factor receptor tyrosine kinase (EGFR-TKI), whose mutation and overexpression is involved in many kinds of cancer. Icotinib is a quinazoline derivative that binds reversibly to the ATP binding site of the EGFR protein, being capable of blocking the signal transduction cascade. It is currently under investigation for its treatment efficacy on the EGFR+ Non-small cell lung cancer.

Uses

Icotinib is a potent and specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with IC50 of 5 nM.

Indications

Icotinib (Conmana?, BetaPharma), an EGFR inhibitor, was approved by the China State FDA in 2011 for the treatment of NSCLC. Icotinib resembles erlotinib in possessing the N-(3-ethylnylphenyl) quinazolin-4-amine core scaffold of erlotinib that binds to the EGFR ATP pocket. An adjacent hydrophobic group was also retained while the solvent exposed two 2-methoxyethyoxysubstituents at the 6- and 7-positions of the quinazoline core were cyclized to afford the tetraoxacyclododecene moiety of icotinib. Efficacy and safety of icotinib as first-line therapy in patients has been evaluated for advanced NSCLC in recent clinical studies.

General Description

Class: receptor tyrosine kinase
Treatment: NSCLC
Oral bioavailability = 52%
Elimination half-life = 5.5 h

References

Tan, F., et al. "Icotinib (BPI-2009H), a novel EGFR tyrosine kinase inhibitor, displays potent efficacy in preclinical studies. " Lung Cancer76.2(2012):177-82.
Shi, Y., et al. "Icotinib versus gefitinib in previously treated advanced non-small-cell lung cancer (ICOGEN): a randomised, double-blind phase 3 non-inferiority trial." Lancet Oncology 14.10(2013):953-61.
Sun, Y., Y. Shi, and L. Zhang. "A randomized, double-blind phase III study of icotinib versus gefitinib in patients with advanced non-small cell lung cancer (NSCLC) previously treated with chemotherapy (ICOGEN)."Journal of Thoracic Oncology 29.15(2011):-.
https://en.wikipedia.org/wiki/Icotinib

Icotinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Icotinib Suppliers

China 102 India 2 United States 15 Global 119

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
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Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
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InvivoChem

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Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
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Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
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BOC Sciences

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Fax: 1-631-614-7828
Email: inquiry@bocsci.com
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Aladdin Scientific

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Country: United States
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TargetMol Chemicals Inc.

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ApexBio Technology

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BOC Sciences

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NE Scientific

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Selleck Chemicals LLC

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Cayman Chemical Company

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Creative Enzymes

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Matrix Scientific

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View Lastest Price from Icotinib manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Icotinib 610798-31-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Icotinib 610798-31-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: Icotinib 610798-31-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 500kg
Release date: 2018-08-19

610798-31-7, IcotinibRelated Search:

Saxagliptin Trelagliptin Pregabalin Ibrutinib Metformin Troglitazone Sofosbuvir Tucatinib Gefitinib Crizotinib Erlotinib Lapatinib PD 173074 LY2603618 PHA-848125 MK-1775 Saracatinib Barasertib (AZD1152-HQPA)

BPI-2009

BP-1096

BPI-2009H

ConMana

Lcotinib

Icotinib

N-(3-Ethynylphenyl)-7,8,10,11,13,14-hexahydro-[1,4,7,10]tetraoxacyclododecino[2,3-g]quinazolin-4-amine

Icotinib (BPI-2009)

BPI-2009H;BPI-2009

[1,4,7,10]Tetraoxacyclododecino[2,3-g]quinazolin-4-amine, N-(3-ethynylphenyl)-7,8,10,11,13,14-hexahydro-

Icotinib int. N-1

N-(3-Ethynylphenyl)-7,8,10,11,13,14-hexahydro-[1,4,7,10]tetraoxacyclododecino[2,3-g]quinazolin

Icotinib, 98%, a potent EGFR inhibitor

Icotinib BP-1096

CS-908

Icotinib(BPI-2009H)

Icotinib USP/EP/BP

otinib

Icotinib,apotentEGFRinhibitor

Icotinib, 10 mM in DMSO

610798-31-7

610793-31-7

Inhibitors

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