4-oxo-3H-pyrazolo[1,5-a]1,3,5-triazine

Product Name: 4-oxo-3H-pyrazolo[1,5-a]1,3,5-triazine
CAS No.: 54346-27-9
Chemical Name: 4-oxo-3H-pyrazolo[1,5-a]1,3,5-triazine
Synonyms: 4-Oxo-3H-pyrazolo<1,5-a>-1,3,5-triazin;6H-pyrazolo[1,5-a][1,3,5]triazin-4-one;4-oxo-3H-pyrazolo[1,5-a]1,3,5-triazine;Pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one;Pyrazolo[1,5-a][1,3,5]triazin-4(1H)-one;1H,4H-pyrazolo[1,5-a][1,3,5]triazin-4-one
CBNumber: CB82618559
Molecular Formula: C5H4N4O
Formula Weight: 136.11
MOL File: 54346-27-9.mol

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4-oxo-3H-pyrazolo[1,5-a]1,3,5-triazine Property

Melting point:: 270 °C (decomp)
Density: 1.74±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 8.89±0.20(Predicted)
Appearance: Light yellow to brown Solid

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

TRC

Product number: P993485
Product name: Pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one
Packaging: 500mg
Price: $310
Updated: 2021/12/16

AK Scientific

Product number: 7832AB
Product name: Pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one
Packaging: 1g
Price: $213
Updated: 2021/12/16

Apolloscientific

Product number: OR924884
Product name: 1H,4H-Pyrazolo[1,5-a][1,3,5]triazin-4-one
Purity: 95%
Packaging: 250mg
Price: $225
Updated: 2021/12/16

AK Scientific

Product number: 7832AB
Product name: Pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one
Packaging: 250mg
Price: $104
Updated: 2021/12/16

Matrix Scientific

Product number: 120071
Product name: Pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one
Purity: 95+%
Packaging: 250mg
Price: $468
Updated: 2021/12/16

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4-oxo-3H-pyrazolo[1,5-a]1,3,5-triazine Chemical Properties,Usage,Production

Synthesis

77668-01-0

122-51-0

54346-27-9

1. Dissolve isoxazole (35.0 g, 506.0 mmol) in ethanol (200 mL) at 0°C and slowly add sodium ethoxide (197 mL, 21% ethanol solution, 532 mmol) while stirring. After the addition was completed, the reaction mixture continued to be stirred for 30 minutes. 2. The solvent was removed by vacuum and water (200 mL) was added to neutralize the reaction mixture. Subsequently, aminourea hydrochloride (56.43 g, 506 mmol) was added and stirred at 25 °C for 16 hours. 3. The reaction mixture was neutralized with NaOH (1N) to pH~7 and then extracted with chloroform (5*). The organic layer was dried over Na2SO4, filtered and concentrated. Purification by chromatography using a hexane-EtOAc gradient elution afforded 5-amino-1H-pyrazole-1-carboxamide as a white solid (13.8 g, 21.6%).TLC Rf = 0.51 (1:1 EtOAc:hexane). 4. a solution of 5-amino-1H-pyrazole-1-carboxamide with triethyl orthoformate was heated at 110 °C for 15 hours. After completion of the reaction, the reaction mixture was concentrated to dryness and ground. 5. The resulting solid was dried in vacuum to afford pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one (8.23 g, 76.6%) as a brown solid. lCMS (m/z): m + H = 137.1; tR = 0.22 min; TLC Rf = 0.44 (9:1 DCM:MeOH).

References

[1] Journal of Organic Chemistry, 2014, vol. 79, # 7, p. 3221 - 3227
[2] Patent: US2012/77814, 2012, A1. Location in patent: Page/Page column 46
[3] Journal of Heterocyclic Chemistry, 1980, vol. 17, p. 1435 - 1439

4-oxo-3H-pyrazolo[1,5-a]1,3,5-triazine Preparation Products And Raw materials

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View Lastest Price from 4-oxo-3H-pyrazolo[1,5-a]1,3,5-triazine manufacturers

Career Henan Chemical Co

Product: Pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one 54346-27-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-02-12

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54346-27-9