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4-oxo-3H-pyrazolo[1,5-a]1,3,5-triazine

Product Name
4-oxo-3H-pyrazolo[1,5-a]1,3,5-triazine
CAS No.
54346-27-9
Chemical Name
4-oxo-3H-pyrazolo[1,5-a]1,3,5-triazine
Synonyms
4-Oxo-3H-pyrazolo<1,5-a>-1,3,5-triazin;6H-pyrazolo[1,5-a][1,3,5]triazin-4-one;4-oxo-3H-pyrazolo[1,5-a]1,3,5-triazine;Pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one;Pyrazolo[1,5-a][1,3,5]triazin-4(1H)-one;1H,4H-pyrazolo[1,5-a][1,3,5]triazin-4-one
CBNumber
CB82618559
Molecular Formula
C5H4N4O
Formula Weight
136.11
MOL File
54346-27-9.mol
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4-oxo-3H-pyrazolo[1,5-a]1,3,5-triazine Property

Melting point:
270 °C (decomp)
Density 
1.74±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
8.89±0.20(Predicted)
Appearance
Light yellow to brown Solid
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

TRC
Product number
P993485
Product name
Pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one
Packaging
500mg
Price
$310
Updated
2021/12/16
AK Scientific
Product number
7832AB
Product name
Pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one
Packaging
1g
Price
$213
Updated
2021/12/16
Apolloscientific
Product number
OR924884
Product name
1H,4H-Pyrazolo[1,5-a][1,3,5]triazin-4-one
Purity
95%
Packaging
250mg
Price
$225
Updated
2021/12/16
AK Scientific
Product number
7832AB
Product name
Pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one
Packaging
250mg
Price
$104
Updated
2021/12/16
Matrix Scientific
Product number
120071
Product name
Pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one
Purity
95+%
Packaging
250mg
Price
$468
Updated
2021/12/16
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4-oxo-3H-pyrazolo[1,5-a]1,3,5-triazine Chemical Properties,Usage,Production

Synthesis

77668-01-0

122-51-0

54346-27-9

1. Dissolve isoxazole (35.0 g, 506.0 mmol) in ethanol (200 mL) at 0°C and slowly add sodium ethoxide (197 mL, 21% ethanol solution, 532 mmol) while stirring. After the addition was completed, the reaction mixture continued to be stirred for 30 minutes. 2. The solvent was removed by vacuum and water (200 mL) was added to neutralize the reaction mixture. Subsequently, aminourea hydrochloride (56.43 g, 506 mmol) was added and stirred at 25 °C for 16 hours. 3. The reaction mixture was neutralized with NaOH (1N) to pH~7 and then extracted with chloroform (5*). The organic layer was dried over Na2SO4, filtered and concentrated. Purification by chromatography using a hexane-EtOAc gradient elution afforded 5-amino-1H-pyrazole-1-carboxamide as a white solid (13.8 g, 21.6%).TLC Rf = 0.51 (1:1 EtOAc:hexane). 4. a solution of 5-amino-1H-pyrazole-1-carboxamide with triethyl orthoformate was heated at 110 °C for 15 hours. After completion of the reaction, the reaction mixture was concentrated to dryness and ground. 5. The resulting solid was dried in vacuum to afford pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one (8.23 g, 76.6%) as a brown solid. lCMS (m/z): m + H = 137.1; tR = 0.22 min; TLC Rf = 0.44 (9:1 DCM:MeOH).

References

[1] Journal of Organic Chemistry, 2014, vol. 79, # 7, p. 3221 - 3227
[2] Patent: US2012/77814, 2012, A1. Location in patent: Page/Page column 46
[3] Journal of Heterocyclic Chemistry, 1980, vol. 17, p. 1435 - 1439

4-oxo-3H-pyrazolo[1,5-a]1,3,5-triazine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-oxo-3H-pyrazolo[1,5-a]1,3,5-triazine Suppliers

China 41 India 2 United States 4 Global 47
CHEMSWORTH
Tel
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Fax
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Email
info@chemsworth.com
Country
India
ProdList
6700
Advantage
30
A.J Chemicals
Tel
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Fax
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Email
sales@ajchem.in
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India
ProdList
6100
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View Lastest Price from 4-oxo-3H-pyrazolo[1,5-a]1,3,5-triazine manufacturers

Career Henan Chemical Co
Product
Pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one 54346-27-9
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2020-02-12

54346-27-9, 4-oxo-3H-pyrazolo[1,5-a]1,3,5-triazineRelated Search:


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  • Pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one
  • 1H,4H-pyrazolo[1,5-a][1,3,5]triazin-4-one
  • Pyrazolo[1,5-a][1,3,5]triazin-4(1H)-one
  • 6H-pyrazolo[1,5-a][1,3,5]triazin-4-one
  • 4-Oxo-3H-pyrazolo<1,5-a>-1,3,5-triazin
  • 54346-27-9