ChemicalBook > CAS DataBase List > OC000459

OC000459

Product Name
OC000459
CAS No.
851723-84-7
Chemical Name
OC000459
Synonyms
1H-Indole-1-acetic acid, 5-fluoro-2-methyl-3-(2-quinolinylmethyl)-;OC-459;CS-581;OC000495;OC000459;OC000459, >=98%;OC000459 USP/EP/BP;OC000459(Timapiprant);Timapiprant (OC000459);Timapiprant, 10 mM in DMSO
CBNumber
CB82620011
Molecular Formula
C21H17FN2O2
Formula Weight
348.37
MOL File
851723-84-7.mol
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OC000459 Property

Boiling point:
574.4±50.0 °C(Predicted)
Density 
1.29
storage temp. 
Store at -20°C
solubility 
DMF: 0.5 mg/ml; DMSO: 1.1 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
form 
A crystalline solid
pka
4.08±0.10(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H303May be harmfulif swallowed

H320Causes eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
12027
Product name
OC000459
Purity
≥98%
Packaging
5mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
12027
Product name
OC000459
Purity
≥98%
Packaging
10mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
12027
Product name
OC000459
Purity
≥98%
Packaging
25mg
Price
$235
Updated
2024/03/01
TRC
Product number
O135000
Product name
OC000459
Packaging
10mg
Price
$165
Updated
2021/12/16
ChemScene
Product number
CS-1285
Product name
Timapiprant
Purity
98.52%
Packaging
10mg
Price
$120
Updated
2021/12/16
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OC000459 Chemical Properties,Usage,Production

Uses

OC000459 is a CRTH2 antagonist which helps in the treatment of allergies, reducing nasal and ocular symptoms in subjects exposed to allergens.

in vivo

Timapiprant (OC000459) (gavage; 2 mg/kg, 10 mg/kg) inhibits blood eosinophilia induced by 13,14-dihydro-15-keto-PGD2 (DK-PGD2) in Rat (ED50=0.04 mg/kg)[1]. Timapiprant (OC000459) (gavage; 0.01 mg/kg, 0.1 mg/kg, 1.0 mg/kg) inhibits airway eosinophilia in response to an aerosol of DK-PGD2 in guinea pigs (ED50=0.01 mg/kg)[1].

IC 50

DP

OC000459 Preparation Products And Raw materials

Raw materials

Preparation Products

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OC000459 Suppliers

Canada 1 China 123 United Kingdom 1 United States 18 Global 143
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4747
Advantage
58
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1493
Advantage
55
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
China Kouting Group Limited
Tel
+86 (21) 5811-6473 5811-6475
Fax
+86 (21) 6129-4103
Email
sales@koutingchina.com
Country
China
ProdList
496
Advantage
60
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Bsisun HK Imoprt And Export Company Limited
Tel
+86-18068513926
Fax
0086-519-85153711
Country
China
ProdList
1277
Advantage
55
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View Lastest Price from OC000459 manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
OC000459 851723-84-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98
Supply Ability
10000KGS
Release date
2025-11-24
Wuhan Nutra Biotechnology Co.,Ltd
Product
OC000459 851723-84-7
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98%+
Supply Ability
100kgs
Release date
2021-05-26
Dingwang Technology (Wuhan) Co., Ltd.
Product
OC000459 851723-84-7
Price
US $0.00/mg
Min. Order
100mg
Purity
99%
Supply Ability
50-100kg
Release date
2023-02-06

851723-84-7, OC000459Related Search:


  • OC000459
  • 2-(5-fluoro-2-Methyl-3-(quinolin- 2-ylMethyl)-1H-indol-1-yl)acetic acid
  • 5-Fluoro-2-Methyl-3-quinolin-2-ylMethylindo-1-yl)-acetic(OC000459)
  • [5-Fluoro-2-methyl-3-(quinolin-2-ylmethyl)indol-1-yl]acetic acid
  • 5-Fluoro-2-methyl-3-(2-quinolinylmethyl)-1H-indole-1-acetic acid
  • OC000495
  • (5-Fluoro-3-isoquinolin-3-ylMethyl-2-Methyl-indol-1-yl)-acetic acid
  • 1H-Indole-1-acetic acid, 5-fluoro-2-methyl-3-(2-quinolinylmethyl)-
  • [5-Fluoro-2-methyl-3-(quinolin-2-ylmethyl)indol-1-yl]acetic acid OC000459
  • OC-459
  • OC000459;OC-000459; OC 000459
  • OC000459, >=98%
  • CS-581
  • OC000459(Timapiprant)
  • 2-[5-FLUORO-2-METHYL-3-(QUINOLIN-2-YLMETHYL)INDOL-1-YL]ACETIC ACID
  • OC000459 USP/EP/BP
  • Timapiprant (OC000459)
  • Timapiprant, 10 mM in DMSO
  • [5-Fluoro-2-methyl-3-(2-quinolinylmethyl)-1H-indol-1-yl]acetic acid
  • 851723-84-7
  • 51723-84-7
  • Inhibitors