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PF5081090

Product Name
PF5081090
CAS No.
1312473-63-4
Chemical Name
PF5081090
Synonyms
PF-5081090;PF 05081090;PF 05081090 - PF 5081090;(2R)-4-[4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1-yl]-N-hydroxy-2-methyl-2-methylsulfonylbutanamide;(αR)-4-(2-Fluoro-4-Methoxyphenyl)-N-hydroxy-α-Methyl-α-(Methylsulfonyl)-2-oxo-1(2H)-pyridinebutanaMide;1(2H)-Pyridinebutanamide, 4-(2-fluoro-4-methoxyphenyl)-N-hydroxy-α-methyl-α-(methylsulfonyl)-2-oxo-, (αR)-;(2R)-4-[4-(2-Fluoro-4-methoxyphenyl)-2-oxo-2H-pyridin-1-yl]-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide;(R)-4-(4-(4-(2H-1,2,3-triazol-2-yl)phenyl)-2-oxopyridin-1(2H)-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide
CBNumber
CB82621977
Molecular Formula
C18H21FN2O6S
Formula Weight
412.43
MOL File
1312473-63-4.mol
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PF5081090 Property

Melting point:
>175°C (dec.)
Density 
1.378±0.06 g/cm3(Predicted)
storage temp. 
room temp
solubility 
DMSO: >5mg/mL (warmed)
pka
8.11±0.50(Predicted)
form 
powder
color 
white to beige
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Axon Medchem
Product number
Axon 2113
Product name
PF 05081090 - PF 5081090
Purity
98%
Packaging
5mg
Price
$104
Updated
2021/12/16
Axon Medchem
Product number
Axon 2113
Product name
PF 05081090 - PF 5081090
Purity
98%
Packaging
2x5mg
Price
$154
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0001529
Product name
PF-5081090
Purity
98.00%
Packaging
5MG
Price
$257.4
Updated
2021/12/16
ApexBio Technology
Product number
B5563
Product name
(R)-4-(4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide
Packaging
10mg
Price
$347
Updated
2021/12/16
Axon Medchem
Product number
Axon 2113
Product name
PF 05081090 - PF 5081090
Purity
98%
Packaging
25mg
Price
$357
Updated
2021/12/16
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PF5081090 Chemical Properties,Usage,Production

Chemical Properties

Pale Beige Solid

Uses

PF-5081090 is a pyridone methylsulfone hydroxamate LpxC inhibitor. PF-5081090 is used as an antibiotic in the treatment of serious gram-negative infections.

in vivo

PF-5081090 (8.75, 75, 300 mg/kg; s.c.; single dose) exhibits a exposure increasing in linear manner across the dose range in mice, with area under the concentration-time curve (AUC) and maximum concentration of drug in serum (Cmax) increasing with a proportional increase in dose[1].
PF-5081090 shows potent efficacies against sentinel strains of P. aeruginosa and K. pneumonia in CD-1 mice, with effective dose (ED50) ranging from 7.4-55.9 mg/kg (against acute septicemia model), <25 mg/kg (against pneumonia model), and 16.8 mg/kg (against neutropenic thigh model) in mice infected with P. aeruginosa PA-1950[1].
Pharmacokinetics of PF-5081090 in CD-1 micea[1]

Dose (mg/kg)Cmax (mg/L)Tmax (h)AUC (h mg/L)Free AUC (h mg/L)T1/2 (h)CL (L/h/kg)Vss (L/kg)
18.755.020.255.091.580.63.792.20
7515.500.3317.605.460.694.323.30
30075.400.3376.3023.700.683.922.53
a Following single subcutaneous doses.

PF5081090 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF5081090 Suppliers

Canada 1 China 30 United Kingdom 1 United States 5 Global 37
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai Changyan Chem & Tech Co., Ltd.
Tel
021-20242659 18930833303
Fax
+86 (21) 2024-2659
Email
Sales@changyanchem.cn
Country
China
ProdList
5001
Advantage
55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Jinan Weicheng Pharmaceutical Technology Co., Ltd
Tel
0531-68656072 15562569859
Fax
0531-68656072
Email
2921569326@qq.com
Country
China
ProdList
57
Advantage
55
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
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View Lastest Price from PF5081090 manufacturers

Career Henan Chemical Co
Product
PF5081090 1312473-63-4
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200g
Release date
2020-02-01

1312473-63-4, PF5081090Related Search:


  • (αR)-4-(2-Fluoro-4-Methoxyphenyl)-N-hydroxy-α-Methyl-α-(Methylsulfonyl)-2-oxo-1(2H)-pyridinebutanaMide
  • (2R)-4-[4-(2-Fluoro-4-methoxyphenyl)-2-oxo-2H-pyridin-1-yl]-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide
  • PF-5081090
  • PF 05081090
  • (R)-4-(4-(4-(2H-1,2,3-triazol-2-yl)phenyl)-2-oxopyridin-1(2H)-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide
  • (2R)-4-[4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1-yl]-N-hydroxy-2-methyl-2-methylsulfonylbutanamide
  • PF 05081090 - PF 5081090
  • 1(2H)-Pyridinebutanamide, 4-(2-fluoro-4-methoxyphenyl)-N-hydroxy-α-methyl-α-(methylsulfonyl)-2-oxo-, (αR)-
  • 1312473-63-4
  • C18H21FN2O6S
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