JNK-IN-8
- Product Name
- JNK-IN-8
- CAS No.
- 1410880-22-6
- Chemical Name
- JNK-IN-8
- Synonyms
- CS-1339;JNK-IN-8;JNK inhibitor 8;JNK Inhibitor XVI;JNK-IN-8 USP/EP/BP;JNK-IN-8 Only for R&D;JNK-IN-8 >=96% (HPLC);JNK-IN-8 JNK Inhibitor XVI;3-(4-(Dimethylamino)but-2-enamido)-N-(3-methyl-4-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide;(E)-3-(4-(diMethylaMino)but-2-enaMido)-N-(3-Methyl-4-(4-(pyridin-3-yl)pyriMidin-2-ylaMino)phenyl)benzaMide
- CBNumber
- CB82624190
- Molecular Formula
- C29H29N7O2
- Formula Weight
- 507.59
- MOL File
- 1410880-22-6.mol
JNK-IN-8 Property
- Density
- 1.283±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- ≥25.4 mg/mL in DMSO; insoluble in H2O; ≥9.24 mg/mL in EtOH with gentle warming and ultrasonic
- form
- powder
- pka
- 13.34±0.70(Predicted)
- color
- white to beige
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1246
- Product name
- JNK-IN-8
- Purity
- ≥96% (HPLC)
- Packaging
- 5MG
- Price
- $185
- Updated
- 2023/06/20
- Product number
- SML1246
- Product name
- JNK-IN-8
- Purity
- ≥96% (HPLC)
- Packaging
- 25MG
- Price
- $704
- Updated
- 2023/06/20
- Product number
- 18096
- Product name
- JNK Inhibitor XVI
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 18096
- Product name
- JNK Inhibitor XVI
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $155
- Updated
- 2024/03/01
- Product number
- 18096
- Product name
- JNK Inhibitor XVI
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $274
- Updated
- 2024/03/01
JNK-IN-8 Chemical Properties,Usage,Production
Uses
JNK-IN-8 has been used as an inhibitor to address the importance of JNK signaling in withaferin A (WFA)-induced apoptosis of myelodysplastic syndromes (MDS)-L cells.
Definition
ChEBI: 3-[[4-(dimethylamino)-1-oxobut-2-enyl]amino]-N-[3-methyl-4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide is a member of benzamides.
Biological Activity
jnk-in-8 is a specific jnk1/2/3 inhibitor with ic50 value of 4.67, 18.7, 0.98 nm respectively [1].c-jun n-terminal kinase (jnk) 1, 2 and 3 belong to the mitogen-activated protein kinase (mapk) family, which are able to phosphorylate c-jun on the ser63 and ser73 residue.they are responsive for stress stimuli, including cytokines and heat shock, and get involved in t cell differentiation and cell apoptosis process. jnk 1 and 2 are ubiquitous in all cell types but jnk 3 is only found in cells of brain, heart and testes tissues.jnk-in-8 is a jnk1/2/3 inhibitor with high specificity. when jnk-in-8 was profiled with a panel of 400 kinases, it exhibited specific binding to jnk 1/2/3 but not to other kinases. crystallization study also found that jnk-in-8 forms covalent bonds with conserved cysteine residue of jnk 1/2/3, resulting in a conformational change of the activation loop that blocks the substrate binding, thereby inhibiting the activity of jnk 1/2/3 [1].in hela cells and a375 cells, pretreatment of cells with jnk-in-8 resulted in the inhibition of c-jun which is a direct phosphorylation substrate of jnk 1/2/3, confirming the inhibitory action of jnk-in-8 on jnk 1/2/3. in hek293-ilr1 cells following stimulation by anisomycin, the jnk-in-8 was observed to inhibit c-jun but not msk1 and p38, and the inhibition was not reversible by removing jnk-in-8 from culture medium. additionally, jnk-in-8 only exhibited on-pathway inhibition of jnk signaling pathway, which can be monitored by the phosphorylation of c-jun [1].
Biochem/physiol Actions
JNK-IN-8 is a potent, selective and irreversible inhibitor of JNK1/2/3 that inhibits phosphorylation of c-Jun. JNK-IN-8 forms covalent bonds with a conserved cysteine residue.
target
JNK1
References
[1]. zhang t et al., discovery of potent and selective covalent inhibitors of jnk. chemical biology. 2012, 19(1):140-154.
JNK-IN-8 Preparation Products And Raw materials
Raw materials
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View Lastest Price from JNK-IN-8 manufacturers
- Product
- JNK-IN-8 1410880-22-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- kg/T
- Release date
- 2019-12-18