ChemicalBook > CAS DataBase List > SLx-2119

SLx-2119

Product Name
SLx-2119
CAS No.
911417-87-3
Chemical Name
SLx-2119
Synonyms
belumosudil;KD-025;SLx2119;CS-1555;SLx 2119;SLx-2119;Rezurock;SLx-2119(KD-025);KD025 (SLx-2119);ROCK inhibitor 2
CBNumber
CB82624291
Molecular Formula
C26H24N6O2
Formula Weight
452.51
MOL File
911417-87-3.mol
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SLx-2119 Property

Melting point:
>228oC (dec.)
Boiling point:
682.6±55.0 °C(Predicted)
Density 
1.318±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
Soluble in DMSO (25 mg/ml)
pka
13?+-.0.40(Predicted)
form 
solid
color 
White
Stability:
Stable for 1 year as supplied from date of purchase. Solutions in DMSO may be stored at -20°C for up to 1 month.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17055
Product name
KD025
Purity
≥98%
Packaging
50mg
Price
$236
Updated
2024/03/01
Cayman Chemical
Product number
17055
Product name
KD025
Purity
≥98%
Packaging
100mg
Price
$413
Updated
2024/03/01
Cayman Chemical
Product number
17055
Product name
KD 025
Purity
≥98%
Packaging
1mg
Price
$49
Updated
2021/12/16
Cayman Chemical
Product number
17055
Product name
KD 025
Purity
≥98%
Packaging
5mg
Price
$221
Updated
2021/12/16
Cayman Chemical
Product number
17055
Product name
KD 025
Purity
≥98%
Packaging
10mg
Price
$59
Updated
2024/03/01
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SLx-2119 Chemical Properties,Usage,Production

Description

KD 025 is an inhibitor of Rho-associated kinase 2 (ROCK2; IC50 = 0.105 μM). It is selective for ROCK2 over ROCK1 (IC50 = 24 μM). KD 025 (10 μM) decreases the expression of connective tissue growth factor (CTGF) and induces remodeling of the actin cytoskeleton in isolated human ileal fibrotic smooth muscle cells. It inhibits heat-killed C. albicans- or S. epidermidis-induced production of IL-17 in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations ranging from 1.25 to 10 μM. KD 025 (100 and 200 mg/kg) reduces infarct volume in a mouse model of cerebral ischemia induced by transient middle cerebral artery occlusion (MCAO). It decreases disease severity in a mouse model of sclerodermatous chronic graft versus host disease (GVHD) when administered at a dose of 150 mg/kg. Formulations containing KD 025 have been used in the treatment of chronic GVHD.

Uses

KD 025 is an inhibitor of Rho-associated protein kinase II (ROCK-II), a serine/threonine kinase that regulates the formation of actin stress fibers and focal adhesions, smooth muscle contraction, and gene expression (1, 2). KD025 has been shown to reduce infarct volume after transient middle cerebral artery occlusion (2).

References

Boerma et al. (2008) Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin; Blood Coagul. Fibrinolysis.?19 709 Zanin-Zhorov et al. (2014) Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism; Natl. Acad. Sci. USA?111 16814 Flynn et al. (2016) Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism; 127 2144 Jagasia et al. (2021) ROCK2 Inhibition with Belumosudil (KD025) for the Treatment of Chronic Graft-Versus-Host Disease; Clin. Invest.?39 1888 Diep et al. (2018) Anti-adipogenic effects of KD025 (SLx-2119), a ROCK2-specific inhibitor, in 3T3-L1 cells; Rep.?8 2477 Diep et al. (2019) KD025 (SLx-2119) suppresses adipogenesis at intermediate stage in human adipose-derived stem cells; Adipocyte?9 114 Wei et al. (2020) ROCK2 inhibition enhances the thermogenic program in white and brown fat tissue in mice; FASEB J.?34 474 Tran and Chun (2021) ROCK2-Specific Inhibitor KD025 Suppresses Adipocyte Differentiation by Inhibiting Casein Kinase 2; Molecules?26 4747

SLx-2119 Preparation Products And Raw materials

Raw materials

Preparation Products

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SLx-2119 Suppliers

China 122 India 2 United States 15 Global 139
Chongqing Chemieliva Pharmaceutical Co., Ltd.
Tel
023-67770219
Fax
+86 (23) 6777-0220
Email
jessica.hu@chemieliva.com
Country
China
ProdList
1426
Advantage
60
Wuhan Shanhai Zhihe Biotechnology Co., Ltd.
Tel
17771424646
Email
shoubull@126.com
Country
China
ProdList
965
Advantage
58
Chemipanda Bio-Tech Co., Ltd.
Tel
+86-571-85224801; 13588483690
Fax
0571-85241599
Email
chemipanda2010@163.com
Country
China
ProdList
109
Advantage
62
Enlian Biomedical (Chongqing) Co., Ltd.
Tel
023-63134718 13048300200
Email
1501533472@qq.com
Country
China
ProdList
60
Advantage
58
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6011
Advantage
61
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
17989
Advantage
64
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4654
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9452
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
18521735133 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25015
Advantage
65
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View Lastest Price from SLx-2119 manufacturers

Shaanxi Haibo Biotechnology Co., Ltd
Product
SLx-2119 911417-87-3
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-08-29

911417-87-3, SLx-2119Related Search:

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  • Rezurock
  • 2-[3-[4-(1H-Indazol-5-ylamino)-2-quinazolinyl]phenoxy]-N-(1-methylethyl)acetamide
  • inhibit,Rho-kinase,KD-025,Rho-associated protein kinase,ROCK2,KD 025,Belumosudil,Anti-fibrotic,SLx 2119,ROK,ROCK,SLx2119,Rho-associated kinase,Inhibitor
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  • API