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SLx-2119

Product Name
SLx-2119
CAS No.
911417-87-3
Chemical Name
SLx-2119
Synonyms
belumosudil;KD-025;SLx2119;CS-1555;SLx 2119;SLx-2119;Rezurock;SLx-2119(KD-025);KD025 (SLx-2119);ROCK inhibitor 2
CBNumber
CB82624291
Molecular Formula
C26H24N6O2
Formula Weight
452.51
MOL File
911417-87-3.mol
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SLx-2119 Property

Melting point:
>228oC (dec.)
Boiling point:
682.6±55.0 °C(Predicted)
Density 
1.318±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
Soluble in DMSO (25 mg/ml)
pka
13?+-.0.40(Predicted)
form 
solid
color 
White
Stability:
Stable for 1 year as supplied from date of purchase. Solutions in DMSO may be stored at -20°C for up to 1 month.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17055
Product name
KD025
Purity
≥98%
Packaging
50mg
Price
$236
Updated
2024/03/01
Cayman Chemical
Product number
17055
Product name
KD025
Purity
≥98%
Packaging
100mg
Price
$413
Updated
2024/03/01
Cayman Chemical
Product number
17055
Product name
KD 025
Purity
≥98%
Packaging
1mg
Price
$49
Updated
2021/12/16
Cayman Chemical
Product number
17055
Product name
KD 025
Purity
≥98%
Packaging
5mg
Price
$221
Updated
2021/12/16
Cayman Chemical
Product number
17055
Product name
KD 025
Purity
≥98%
Packaging
10mg
Price
$59
Updated
2024/03/01
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SLx-2119 Chemical Properties,Usage,Production

Description

KD 025 is an inhibitor of Rho-associated kinase 2 (ROCK2; IC50 = 0.105 μM). It is selective for ROCK2 over ROCK1 (IC50 = 24 μM). KD 025 (10 μM) decreases the expression of connective tissue growth factor (CTGF) and induces remodeling of the actin cytoskeleton in isolated human ileal fibrotic smooth muscle cells. It inhibits heat-killed C. albicans- or S. epidermidis-induced production of IL-17 in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations ranging from 1.25 to 10 μM. KD 025 (100 and 200 mg/kg) reduces infarct volume in a mouse model of cerebral ischemia induced by transient middle cerebral artery occlusion (MCAO). It decreases disease severity in a mouse model of sclerodermatous chronic graft versus host disease (GVHD) when administered at a dose of 150 mg/kg. Formulations containing KD 025 have been used in the treatment of chronic GVHD.

Uses

KD 025 is an inhibitor of Rho-associated protein kinase II (ROCK-II), a serine/threonine kinase that regulates the formation of actin stress fibers and focal adhesions, smooth muscle contraction, and gene expression (1, 2). KD025 has been shown to reduce infarct volume after transient middle cerebral artery occlusion (2).

brand name

Rezurock

General Description

Class: serine-threonine kinase; Treatment: chronic GVHD; Other name: SLx-2119, KD025; Oral bioavailability = 64%; Elimination half-life = 19 h; Protein binding = 99.9%

target

Primary target: ROCK2

References

Boerma et al. (2008) Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin; Blood Coagul. Fibrinolysis.?19 709 Zanin-Zhorov et al. (2014) Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism; Natl. Acad. Sci. USA?111 16814 Flynn et al. (2016) Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism; 127 2144 Jagasia et al. (2021) ROCK2 Inhibition with Belumosudil (KD025) for the Treatment of Chronic Graft-Versus-Host Disease; Clin. Invest.?39 1888 Diep et al. (2018) Anti-adipogenic effects of KD025 (SLx-2119), a ROCK2-specific inhibitor, in 3T3-L1 cells; Rep.?8 2477 Diep et al. (2019) KD025 (SLx-2119) suppresses adipogenesis at intermediate stage in human adipose-derived stem cells; Adipocyte?9 114 Wei et al. (2020) ROCK2 inhibition enhances the thermogenic program in white and brown fat tissue in mice; FASEB J.?34 474 Tran and Chun (2021) ROCK2-Specific Inhibitor KD025 Suppresses Adipocyte Differentiation by Inhibiting Casein Kinase 2; Molecules?26 4747

SLx-2119 Preparation Products And Raw materials

Raw materials

Preparation Products

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SLx-2119 Suppliers

China 136 India 2 United States 16 Global 154
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
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Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Accela ChemBio Inc.
Tel
+1-858-6993322
Fax
(+1)-858-876-1948
Email
info@accelachem.com
Country
United States
ProdList
17453
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19553
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58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38632
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58
United States Biological
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sales@advtechind.com
Country
United States
ProdList
6075
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58
ApexBio Technology
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sales@apexbt.com
Country
United States
ProdList
6251
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Focus Biomolecules
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sales@focusbiomolecules.com
Country
United States
ProdList
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Cayman Chemical Company
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--
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Email
cayman@caymanchem.com
Country
United States
ProdList
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United States Biological
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chemicals@usbio.net
Country
United States
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Creative Enzymes
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Combi-Blocks Inc.
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Axon Medchem LLC
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Country
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View Lastest Price from SLx-2119 manufacturers

Shaanxi Haibo Biotechnology Co., Ltd
Product
SLx-2119 911417-87-3
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-08-29

911417-87-3, SLx-2119Related Search:

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  • 2-[3-[4-(1H-Indazol-5-ylamino)-2-quinazolinyl]phenoxy]-N-(1-methylethyl)acetamide
  • inhibit,Rho-kinase,KD-025,Rho-associated protein kinase,ROCK2,KD 025,Belumosudil,Anti-fibrotic,SLx 2119,ROK,ROCK,SLx2119,Rho-associated kinase,Inhibitor
  • 2- [3- [4- [(1H-indazol-5-yl) amino] Quinazoline -2-yl] phenoxy] - N-isopropylacetamide
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  • 911417-87-3
  • API